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Pediatric liver transplant recipients who undergo transfer to the adult healthcare service have good long-term outcomes
American Journal of Transplantation
Liver transplantation has transformed survival for children with liver disease necessitating the transfer of a growing number of patients to the adult healthcare service. The impact of transfer on outcomes remains unclear. The aim of this single-center study of 137 consecutive pediatric liver transplant recipients was to examine the effect of transfer on patient and graft survival. The median time from transplant to transfer was 10.4 years and the median age of the patients at transfer was 18.6 years. After transfer, there were 5 re-transplants and 12 deaths in 14 patients. The estimated posttransfer 10-year patient and graft survival was 89.9 percent and 86.2 percent, respectively. Overall, 4 patients demonstrated graft loss as a consequence of chronic rejection.
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SOCIETY NEWS


FQAPI Worksheet Webinar March 11
ASTS
ASTS, AST and representatives from the CMS Survey and Certification Group are pleased to announce a series of webinars on various Quality Assessment and Performance Improvement (QAPI) topics throughout 2015.
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2015 Winter Symposium Webcasts available
ASTS
Webcasts from the pre-meeting and Winter Symposium Webcasts are now available.
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Get the member rate for ATC!
ASTS
Have you paid your ASTS dues? To receive the member rate for ATC, you must be a member in good standing by April 1. Allowing your membership to lapse also impacts your AJT subscription; delivery to those who have not yet paid membership dues will stop as of March.
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TOP NEWS


Many organ transplant surgeons in U.S. experience burnout
News Medical
Despite saving thousands of lives yearly, nearly half of organ transplant surgeons report a low sense of personal accomplishment and 40 percent feel emotionally exhausted, according to a national study on transplant surgeon burnout. The findings are published in the American Journal of Transplantation. Senior staff psychologist Michelle Jesse, Ph.D., led the Henry Ford Transplant Institute study, with liver transplant surgeon Dr. Marwan Abouljoud and Henry Ford senior staff psychologist Anne Eshelman, Ph.D.
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PRODUCT SHOWCASE
 
You care about your transplant patients. And so do we. That’s why we’re introducing Astellas Cares—a new program that offers you customized tools, educational resources, and comprehensive support to help your patients care for their health. To register, visit AstellasCares.com/Transplant today.
 


Hepatic artery stenosis after liver transplantation: Is endovascular treatment always necessary?
Liver Transplantation (login required)
Hepatic artery stenosis (HAS) is thought to predispose patients to biliary complications secondary to ischemic injury. Despite this, the clinical significance of HAS remains poorly defined. The aims of this study were to determine the prevalence and outcomes of HAS and to define which patients might benefit from endovascular treatment.
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Complement inhibition in HLA-incompatible kidney transplants: Persisting antibody-mediated injury despite marked decrease of clinical ABMR
American Journal of Transplantation
In this issue of the American Journal of Transplantation, Cornell et al report the mid-term follow-up of their previous case-control study investigating the efficacy of eculizumab (a humanized anti-component C5 monoclonal antibody) to prevent antibody-mediated rejection (ABMR) in kidney transplant recipients with preformed donor-specific anti-HLA antibodies (anti-HLA DSA). Given that ABMR is the leading cause of allograft loss in recipients with preformed anti-HLA DSA and that the complement system activation has been demonstrated as being a key pathway in ABMR pathogenesis, they hypothesized that terminal complement inhibition could improve allograft outcomes in these high-risk patients.
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'Superdonors' poised to change the world of transplant surgery
By Alan Kelsky
All too often we hear heartbreaking stories of a child needing a kidney or liver transplant, but neither parents match. Transplanting an organ that is not closely matched to a recipient's blood type, antibodies and other key markers generally means that the receiver of the donated organ will immediately begin to reject it. However, science uncovered that a small percentage of humans have a type of human leukocyte antigen that allows their tissues to be transplanted more easily. Now there is talk about creating a biobank of these cells from HLA "matching superdonors."
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How 3-D printing could end the deadly shortage of donor organs
The Huffington Post
Three-dimensional printing has been used to make everything from pizza to prostheses, and now researchers are working on using the emerging technology to fabricate hearts, kidneys, and other vital human organs. That would be very big news, as the number of people who desperately need an organ transplant far outstrips the number of donor organs available. On average, about 21 Americans die every day because a needed organ was unavailable.
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HIV no bar to kidney transplant
MedPage Today
People with HIV and chronic kidney disease can safely and successfully get a new organ from an HIV-positive donor, researchers reported. In a prospective case series in South Africa, 74 percent of HIV patients getting an HIV-positive kidney were alive after 5 years, according to Elmi Muller, MBChB, of the University of Cape Town in South Africa, and colleagues.
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Serum sodium and survival benefit of liver transplantation
Liver Transplantation (login required)
Hyponatremia is associated with elevated wait-list mortality among end-stage liver disease candidates for liver transplantation (LT). However, the effect of low serum sodium on the survival benefit of LT has not been examined. We sought to determine whether pretransplant hyponatremia is associated with an altered LT survival benefit. Data were obtained from the Scientific Registry of Transplant Recipients. The study population consisted of adults (age ≥ 18 years) placed on the waiting list for LT between Jan. 1, 2005 and Dec. 31, 2012.
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Lung transplantation in chronic obstructive pulmonary disease: long-term survival, freedom from bronchiolitis obliterans syndrome, and factors influencing outcome
Clinical Transplantation (login required)
Lung transplantation (LTx) remains the definitive treatment for end-stage lung failure, whereas chronic obstructive pulmonary disease (COPD) represents one of the main diagnoses leading to the indication for a transplant. We sought to assess long-term outcomes after LTx in patients diagnosed with COPD and analyze factors influencing outcome in this frequent patient cohort.
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ASTS NewsBrief
Colby Horton, Vice President of Publishing, 469.420.2601
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