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National healthcare delivery systems influence lung transplant outcomes for cystic fibrosis
American Journal of Transplantation (login required)
Successful lung transplantation (LTx) depends on multiple components of healthcare delivery and performance. Therefore, we conducted an international registry analysis to compare post-LTx outcomes for cystic fibrosis (CF) patients using the UNOS registry in the United States and the National Health Service (NHS) Transplant Registry in the United Kingdom. Patients with CF who underwent lung or heart–lung transplantation in the United States or United Kingdom between Jan. 1, 2000 and Dec. 31, 2011 were included. The primary outcome was all-cause mortality.
QAPI Objective Measures Webinar April 8
ASTS, AST and representatives from the CMS Survey and Certification Group are pleased to announce the upcoming webinar in a series on various Quality Assessment and Performance Improvement (QAPI) topics throughout 2015.
Congratulations to the 2015 ASTS Research Grants recipients!
The 2015 recipients of the ASTS Research Grants have been announced! The recipients will be recognized at the American Transplant Congress at 9:30 a.m. on Monday, May 4, in the general session room. Please join us as we celebrate this critical part of the Society's mission to advance the art and science of transplant surgery!
ASTS events at ATC
ASTS members, please join us for these events while you're in Philadelphia:
- ASTS Pioneer Award Presentation, Sunday, May 3, 9:45 a.m.
- ASTS Research Grant Presentations, Monday, May 4, 9:30 a.m.
- ASTS Presidential Address, Monday, May 4, 9:45 a.m.
- ASTS Business Meeting and Reception, Tuesday, May 5, at 5:45 p.m.
Testing APOL1 gene variants in deceased kidney donors may improve transplant outcomes
Kidney transplantation outcomes from deceased African-American donors may improve through rapid testing for apolipoprotein L1 gene (APOL1) renal risk variants at the time of organ recovery, according to a new study led by researchers at Wake Forest Baptist Medical Center. Variation in the APOL1 gene is associated with up to 40 percent of all kidney diseases in African-Americans who undergo dialysis or kidney transplantation, and APOL1 kidney disease risk variants are only present on the chromosomes of individuals who possess recent African ancestry, such as African-Americans, according to the researchers.
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Immunophenotypic profile and increased risk of hospital admission for infection in infants born to female kidney transplant recipients
American Journal of Transplantation (login required)
Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to healthy mothers were evaluated. T, B, NK, NKT, γδT cells were assessed by flow cytometry and functional evaluation of T and dendritic cells after in vitro activation was performed at birth and at 8 months of age.
Predictors of poor outcome among older liver transplant recipients
Clinical Transplantation (login required)
With the increasing age of recipients undergoing orthotopic liver transplant (OLT), there is need for better risk stratification among them. Our study aims to identify predictors of poor outcome among OLT recipients ≥60 yr of age. All patients who underwent OLT at Cleveland Clinic from January 2004 to April 2010 were included. Baseline patient characteristics and post-OLT outcomes (mortality, graft failure, length of stay, and major post-OLT cardiovascular events) were obtained from prospectively collected institutional registry. Among patients ≥60 yr of age, multivariate regression modeling was performed to identify independent predictors of poor outcome.
Kidney transplant survival rate found worse in recipients with HCV vs. HIV
Kidney transplant recipients that were positive for HIV had a greater survival rate vs. kidney transplant recipients with hepatitis C virus infection and recipients coinfected with HIV and hepatitis C virus infection, according to new study data.
Higher mortality in registrants with sudden model for end-stage liver disease increase: Disadvantaged by the current allocation policy
Liver allocation is based on current Model for End-Stage Liver Disease (MELD) scores, with priority in the case of a tie being given to those waiting the longest with a given MELD score. We hypothesized that this priority might not reflect risk: registrants whose MELD score has recently increased receive lower priority but might have higher wait-list mortality. We studied wait-list and posttransplant mortality in 69,643 adult registrants from 2002 to 2013.
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Prognostic value of cardiac tests in potential kidney transplant recipients: A systematic review
Transplantation (login required)
Whether abnormal myocardial perfusion scintigraphy (MPS), dobutamine stress echocardiography (DSE) or coronary angiography, performed during preoperative evaluation for potential kidney transplant recipients, predicts future cardiovascular morbidity is unclear. We assessed test performance for predicting all-cause mortality, cardiovascular mortality and major adverse cardiac events (MACE).
CUMC researchers identify mechanism of kidney transplant tolerance
Columbia University Medical Center (CUMC) researchers have pinpointed the immune system mechanism that allows a kidney transplant to be accepted without lifelong immunosuppressive drugs, a significant step toward reducing or eliminating the need for costly and potentially toxic immunosuppressant drugs and improving long-term transplant success. The findings were published in the Jan. 28 online issue of Science Translational Medicine.
Insufficient protein intake is associated with increased mortality in 630 patients with cirrhosis awaiting liver transplantation
National Center for Biotechnology Information
For patients awaiting liver transplantation, researchers aimed to determine the prevalence and predictors of insufficient protein intake as well as to determine whether very low protein intake was an independent predictor of malnutrition and mortality. Adults with cirrhosis who were activated on our local liver transplant waiting list between January 2000 and October 2009 were included. Estimated protein intake was derived from dietary records.
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