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Objective estimates improve risk stratification for primary graft dysfunction after lung transplantation
American Journal of Transplanation (login required)
Primary graft dysfunction (PGD) is a major cause of early mortality after lung transplant. We aimed to define objective estimates of PGD risk based on readily available clinical variables, using a prospective study of 11 centers in the Lung Transplant Outcomes Group (LTOG). Derivation included 1255 subjects from 2002 to 2010; with separate validation in 382 subjects accrued from 2011 to 2012. We used logistic regression to identify predictors of grade 3 PGD at 48/72 h, and decision curve methods to assess impact on clinical decisions.
Genomics grant deadline April 23
The deadline to submit applications for the ASTS Faculty Research Grant for Biomarker Discovery and Functional Genomics Applications is Thursday, April 23, at 3 p.m. Eastern.
ATC 2016 program proposals due June 5
Program proposals are being accepted for the 2016 American Transplant Congress ATC in Boston. The deadline to submit proposals is June 5, 2015.
ASTS events at ATC
ASTS members, please join us for these events while you’re in Philadelphia:
- ASTS Pioneer Award Presentation, Sunday, May 3, 9:45 a.m.
- ASTS Presidential Address and Research Grant Presentations, Monday, May 4, 9:45 a.m.
- ASTS Business Meeting and Reception, Tuesday, May 5, at 5:45 p.m.
Quantifying prognostic impact of prescription opioid use before kidney transplantation through linked registry and pharmaceutical claims data
Transplantation (login required)
Limited data are available on the outcome implications of prescription narcotic use before kidney transplantation. This study examined a novel database wherein national transplant registry identifiers for kidney transplant recipients were linked to records from a large U.S. pharmaceutical claims clearinghouse (2005‐2010).
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Incidence and risk factors for tuberculosis after liver transplantation in an endemic area: A nationwide population-based matched cohort study
American Journal of Transplantation (login required)
Morbidity and mortality from tuberculosis (TB) are high in Taiwan. We conducted a nationwide population-based matched cohort study using data retrieved from the Taiwan's National Health Insurance Research Database to determine the impact of TB after liver transplantation (LT). During 2000–2011, we identified 3202 liver transplant recipients and selected subjects from the general population matched for age, sex, and comorbidities on the same index date of recognition of LT with a 1:10 ratio. The data were analyzed using Cox proportional hazards models.
Systematic serological testing for hepatitis E virus in kidney transplant recipients
Journal of Clinical Microbiology (login required)
Hepatitis E virus (HEV) genotype 3 is endemic in Europe and hyperendemic in southern France. Recent reports of a high prevalence of HEV RNA in blood donations and in culinary specialties from this geographical area confirmed the endemicity of HEV and sources of viral transmission in this geographical area. HEV causes acute and chronic hepatitis in solid organ transplant recipients.
T-cell immunotherapy shown to be effective in treating infection after lung transplantation
Lung Disease News
A new study entitled “Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation” was published in the Clinical & Translational Immunology by Chien-Li Holmes-Liew from the South Australian Lung Transplant Unit at Royal Adelaide Hospital in Australia, along with colleagues. In this study, the researchers showed a successful adoptive transfer of autologous cytomegalovirus (CMV)-specific T cells to a lung transplant (LTx) patient with ganciclovir-resistant tissue-invasive CMV disease, leading to an uncomplicated long-term survival.
Lung transplant waitlist mortality: Height as a predictor of poor outcomes
Pediatric Transplantation (login required)
The LAS was designed to minimize pretransplant mortality while maximizing post-transplant outcome. Recipients less than 12 are not allocated lungs based on LAS. Waitlist mortality has decreased for those greater than 12, but not less than 12, suggesting this population may be disadvantaged. To identify predictors of waitlist mortality, a retrospective analysis of the UNOS database was performed since implementation of the LAS.
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Organ donor found via social media prompts international debate
Medical experts in Belgium are weighing whether to allow the transplant of an organ that was found through social media, The Atlantic reports. On Jan. 12, Roel Marien posted a message on Facebook seeking a kidney from a "living donor" between ages 18 and 45. Within a month, eight individuals responded saying they would donate a kidney if they were a good match. However, in March doctors at the University Medical Center in Leuven refused to perform the surgery, saying it was unfair to others.
Use of model for end-stage liver disease exceptions for donation after cardiac death graft recipients relisted for liver transplantation
Liver Transplantation (login required)
Donation after cardiac death (DCD) liver transplantation is associated with increased biliary complications and graft failure. Yet for unclear reasons, DCD recipients relisted for transplantation have lower wait-list mortality than other retransplant candidates. Researchers used Organ Procurement and Transplantation Network and United Network for Organ Sharing data from 2002 to 2011 to evaluate all DCD recipients relisted for transplantation to evaluate the impact of the utilization of Model for End-Stage Liver Disease (MELD) exception points on wait-list outcomes.
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