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First-in-human study of the safety and efficacy of TOL101 induction to prevent kidney transplant rejection
American Journal of Transplantation
TOL101 is a murine IgM mAb targeting the αβ TCR. Unlike other T cell targets, the αβ TCR has no known intracellular signaling domains and may provide a nonmitogenic target for T cell inactivation. Authors report the 6-month Phase 2 trial data testing TOL101 in kidney transplantation. The study was designed to identify a dose that resulted in significant CD3 T cell modulation (<25 T cell/mm3), to examine the safety and tolerability of TOL101 and to obtain preliminary efficacy information.
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SOCIETY NEWS


ASTS at WTC
ASTS
There are several events to keep in mind as you make your travel arrangements for the World Transplant Congress in San Francisco July 26-31. ASTS members, don't forget to stop by the ASTS booth to pick up your copy of the 40th anniversary book!
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2013 ASTS Transplant Surgeon Compensation Survey available
ASTS
The 2013 ASTS Transplant Surgeon Compensation Survey Report is available in the ASTS store (please log in for member pricing). Individuals can use it to easily compare their salary and benefits with their peers, while institutions can use the data to benchmark compensation. A staff level and a leadership level version of the results are available.
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ASTS keeps you informed with updates for medical professionals webpage
ASTS
ASTS maintains a webpage for news about recalls, drug approvals, and more. It joins the REMS page as part of the Knowledge Base (under "Resources"). Check it out and make sure you have the latest news you need!
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TOP NEWS


PRODUCT SHOWCASE
  SRTR Monitoring in Real-Time
XynManagement provides an integrated solution for transplant centers to identify SRTR risk, track outcomes and improve performance. XynManagement’s HIPPA-compliant, cloud-based software platform improves data capture, ensuring your data reflect the true risk of transplants performed. Using simple, effective graphics, the system predicts risk at the individual patient level and assesses program-wide risk on future SRTR reports.
 


Acute rejection linked to ketoconazole
Renal & Urology News
Using ketoconazole in combination with tacrolimus in kidney transplant patients may increase their risk of acute rejection, according to findings presented at the National Kidney Foundation's 2014 Spring Clinical Meetings in Las Vegas.
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Ascites, sodium level increased mortality for children awaiting liver transplantation
Healio
The presence of ascites and serum sodium variables among pediatric cirrhotic patients reduced survival rates within 90 days after inclusion on a liver transplantation wait list, according to recent study results. Researchers analyzed 522 patients with cirrhosis on a liver transplant wait list between October 2000 and February 2012. Sixty-six percent of patients were aged younger than 12 months, and 40 percent of the entire cohort showed ascites. Seventy-nine percent of patients with hyponatremia presented ascites.
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Impact of urinary tract infection on allograft function after kidney transplantation
Clinical Transplantation (login required)
Urinary tract infection is the most common infectious complication after kidney transplantation. We aim to determine its impact on allograft function as indicated by several measures such as iothalamate glomerular filtration rate, estimated glomerular filtration rate, and creatinine value.
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Diarrhea caused by viruses in transplant recipients
Transplant Infectious Disease
Diarrhea is a common complication after solid organ transplantation, and viruses are emerging as important but underestimated causative agents. Viral infections in solid organ transplant recipients can result in severe and prolonged diarrhea with significant patient morbidity and graft complications. Cytomegalovirus remains the most common of the viruses to cause diarrhea, but other viruses are being increasingly recognized, including norovirus, rotavirus and adenovirus. This article reviews the epidemiology, clinical presentation, diagnosis, management and outcomes of these viral causes of diarrhea in SOT patients.
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Procurement for visceral organ transplantation: where to cannulate and how to perfuse?
Current Opinion in Organ Transplantation (login required)
Despite significant improvements in visceral organ transplantation over the last few decades, some technical aspects of organ harvesting remain controversial. The purpose of this article is to review and summarize the latest literature on how to perfuse in multiorgan procurement.
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Molecular classifiers for acute kidney transplant rejection in peripheral blood by whole genome gene expression profiling
American Journal of Transplantation (login required)
There are no minimally invasive diagnostic metrics for acute kidney transplant rejection, especially in the setting of the common confounding diagnosis, acute dysfunction with no rejection. Thus, though kidney transplant biopsies remain the gold standard, they are invasive, have substantial risks, sampling error issues and significant costs and are not suitable for serial monitoring. Global gene expression profiles of 148 peripheral blood samples from transplant patients with excellent function and normal histology, AR and ADNR, from two independent cohorts were analyzed with DNA microarrays.
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Vitamin D deficiency, parathyroid hormone levels and bone disease among patients with end-stage liver disease and normal serum creatinine
Clinical Transplantation (login required)
Vitamin D deficiency is common among patients with end-stage liver disease. The primary aim of this study was to assess the prevalence of vitamin D deficiency, secondary hyperparathyroidism and bone disease in patients with ESLD awaiting LT.
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TRENDING ARTICLES
Missed our previous issues? See which articles your colleagues read most.

    Study: Hepatitis C disease severity in living versus deceased donor liver transplant recipients (NCBI)
Survival of recipients of livers from donation after circulatory death who are relisted and undergo retransplant for graft failure (American Journal of Transplantation)
Assessing the efficacy of kidney paired donation-performance of an integrated 3-site program (Transplantation (login required))
RAPID Software Available Free to ASTS Members (ASTS)

Don't be left behind. Click here to see what else you missed.


 

ASTS NewsBrief
Colby Horton, Vice President of Publishing, 469.420.2601
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Tammy Gibson, Content Editor, 469.420.2677   
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