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The challenges of transplant data an important topic at upcoming Transplant Congress
Nephrology News & Issues
How should you interpret data from the U.S. Renal Data System and UNOS dealing with kidney transplant outcomes? These topics are part of a full-day review on the use of data and how to conduct clinical trials at the annual American Transplant Congress, coming soon to Seattle.
New scientific and clinical information relevant to solid organ and tissue transplantation will be revealed at the 2013 American Transplant Congress (ATC), taking place May 18-22, in Seattle. It is the 13th joint annual meeting of the American Society of Transplant Surgeons and the American Society of Transplantation.
Check out the new ASTS.org
ASTS.org not only has a new look, but new functionality! All members were sent an email with their username and new password. If you did not receive it, please click on "Member Log In" and try the "forgot password" link or contact firstname.lastname@example.org for your login information so you can see all the new site has to offer!
ASTS events at ATC
If you are planning to attend the American Transplant Congress in Seattle May 18–22, don't forget these ASTS events:
Presentation of the Pioneer Award at 10 a.m. on Sunday, May 19, to Ronald Busuttil, MD, PhD, in the general session room
Presentation of the ASTS research grants at 9:15 a.m. on Tuesday, May 21, in the general session room
ASTS Presidential Address at 9:30 a.m. on Tuesday, May 21, in the general session room
ASTS Business Meeting at 5:45 p.m. Tuesday, May 21 (members only), in Room 2AB
ASTS Member Reception at 7:00 p.m. in the North Galleria
ARTS Meeting in Seattle
Pfizer's ARTS (Advancing Research in Transplantation Science) Research Update meeting will be held in Seattle on Saturday, May 18, 7:30 - 9:30 p.m. in the Issaquah Room of the Sheraton Hotel. Presentations of the 9 ARTS research projects on mTOR inhibition will be given by the investigators combined with round table discussions. The meeting is open to the public on a first-come, first-served basis to accommodate the room's maximum capacity.
New transplant technology keeps organs 'alive' outside body
In every medical drama the scene is the same: The surgeon carefully places the delicate organ in a cooler filled with ice and snaps the lid shut. The transplant team then sprints toward the door, hoping to reach its patient in time.
That speed isn't just for dramatic effect. Transplant teams rush because they have less than eight hours to transport the organ to the operating room, prepare it for surgery and implant it into the recipient's body.
Tumor biology and pre-transplant locoregional treatments determine outcomes in patients with T3 hepatocellular carcinoma undergoing liver transplantation
Clinical Transplantation (subscription required)
Liver transplantation is the optimal treatment for patients with hepatocellular carcinoma (HCC) and cirrhosis. This study was conducted to determine the impact of pre-transplant locoregional therapy (LRT) on HCC and the institution's experience with expansion to United Network of Organ Sharing Region 4 T3 (R4T3) criteria.
Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis
Journal of the American Society of Nephrology
The molecular mechanisms that maintain podocytes and consequently, the integrity of the glomerular filtration barrier are incompletely understood. Here, researchers show that the class III phosphoinositide 3-kinase vacuolar protein sorting 34 (Vps34) plays a central role in modulating endocytic pathways, maintaining podocyte homeostasis.
Groundbreaking surgery for girl born without windpipe
The New York Times
Using plastic fibers and human cells, doctors have built and implanted a windpipe in a 2 ½-year-old girl — the youngest person ever to receive a bioengineered organ. The surgery, which took place on April 9 at Children's Hospital of Illinois is only the sixth of its kind and the first to be performed in the United States. It was approved by the Food and Drug Administration under rules that allow experimental procedures when otherwise the patient has little hope of survival.
Managing bone disease in kidney transplant recipients
Renal & Urology News
Bone disease is a well-known complication in kidney transplant recipients, who experience a raid loss of bone mass, especially during the early post-transplant period. The management of this bone loss often is insufficient and nephrologists and other clinicians involved in the care of renal transplant recipients need to understand mineral bone disease in these patients and be aware of the various treatment options available to prevent bone loss.
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Incidence of donor-specific antibodies in kidney transplant patients following conversation to an everolimus-based calcineruin inhibitor-free regimen
Clinical Transplantation (subscription required)
Scarce data exist regarding the incidence of donor-specific antibodies (DSAs) in kidney transplant patients receiving everolimus-based immunosuppression without calcineurin inhibitors (CNIs). The aim of this retrospective case–control study was to compare the incidence of de novo DSAs in patients converted to an everolimus-based regimen without CNIs with that seen in patients maintained on CNIs.
Everolimus-based immunosuppression post-liver transplant as effective as tacrolimus with better renal function
Liver transplant recipients who received everolimus-based immunosuppression with reduced tacrolimus experienced similar results to those treated with standard tacrolimus, while maintaining better renal function, in a study presented at the International Liver Congress in Amsterdam.
Local access to subspecialty care influences the chance of receiving a liver transplant
Liver Transplantation (subscription required)
Prior studies have examined the impact of demographic factors on liver transplant outcomes. These factors may be surrogate markers for access to medical care. Researchers investigated physician density in referred patients' hospital service areas (HSAs) as a factor in patients' probability of receiving a liver transplant. Researchers performed a retrospective review of patients referred for liver transplantation from 2002 through 2010.
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