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Autophagy: Basic principles and relevance to transplant immunity
American Journal of Transplantation (login required)
Autophagy developed into a rapidly expanding field detailing its molecular mechanism and relevance in health and disease. Autophagy is an evolutionarily conserved process that summarizes a pathway in which intracellular material is degraded within the lysosome and where the macromolecular constituents are recycled. This "self-eating" process was originally described in a cell under starvation but now numerous studies established autophagy as a cellular response to stress.
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SOCIETY NEWS


Register for the ASTS Anniversary Reception
ASTS
ASTS' celebration of its 40th anniversary will continue with a special reception during the World Transplant Congress on Tuesday, July 29, at 7 p.m. If you plan to attend, you must RSVP online and pick up your official VIP entry pass at the ASTS booth in the Exhibit Hall. There's no charge, but this event is limited to ASTS members and invited guests. Click here to RSVP (don't forget to log in!) before July 8.
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Help fund the future!
ASTS
The ASTS Foundation Fund the Future Campaign has a goal of raising $100,000 to fund research grants by June 30. We need your help! Please consider donating any amount.
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TOP NEWS


Study: Some liver transplant patients able to stop taking immunosuppressants
The Wall Street Journal
A small but intriguing new study found that some people with hepatitis C who underwent a liver transplant were eventually able to stop taking immunosuppressant drugs designed to keep the recipient from rejecting the new organ. The surprising result, published in the journal Science Translational Medicine, runs counter to what was previously believed—that having a disease such as hepatitis C that triggers an immune response inhibits the body's ability to tolerate a new organ. It also suggests a new avenue for future research to improve the acceptance of organs in transplant recipients.
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Frailty predicts waitlist mortality in liver transplant candidates
American Journal of Transplantation (login required)
We aimed to determine whether frailty, a validated geriatric construct of increased vulnerability to physiologic stressors, predicts mortality in liver transplant candidates. Consecutive adult outpatients listed for liver transplant with laboratory Model for End-Stage Liver Disease (MELD) ≥ 12 at a single center underwent four frailty assessments: Fried Frailty, Short Physical Performance Battery, Activities of Daily Living (ADL) and Instrumental ADL scales.
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An analysis of pancreas transplantation outcomes based on age groupings — an update of the UNOS Database
Clinical Transplantation (login required)
Previously, increasing age has been a part of the exclusion criteria used when determining eligibility for a pancreas transplant. However, the analysis of pancreas transplantation outcomes based on age groupings has largely been based on single center reports. A UNOS database review of all adult pancreas and kidney-pancreas transplants between 1996 and 2012 was performed in the following.
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Case of girl who fought for adult lung transplant leads to policy change
CNN
A year ago, Sarah Murnaghan, an 11-year-old Pennsylvania girl, was fighting for her life while her family waged a campaign to change a national policy on lung transplants for child recipients. Their battle has now led to permanent policy change. Recently, the Organ Procurement and Transplant Network and United Network for Organ Sharing announced their decision to allow some children ages 11 or younger to receive additional priority for lung transplants, including lungs from older donors, according to a statement from UNOS.
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Graft vessel disease following heart transplantation: A systematic review of the role of statin therapy
World Journal of Surgery (login required)
Graft vessel disease (GVD) is a significant cause of morbidity and mortality in cardiac allograft recipients. Hyperlipidemia is a risk factor for GVD, and the majority of patients will display abnormal lipid profiles in the years following transplant. This systematic review aims to establish the clinical impact of statins in cardiac allograft recipients, critically appraising the literature on this subject.
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The perioperative management of patients undergoing combined heart-liver transplantation
Transplantation (login required)
Combined heart-liver transplantation (CHLT) is an uncommonly performed procedure for patients with coexisting cardiac and liver disease. A retrospective review was performed of patients undergoing CHLT at our institution from 1999 to 2013. Information related to preoperative organ function, intraoperative management, surgical approach, transfusions, postoperative findings, and 30-day mortality was reviewed.
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TRENDING ARTICLES
Missed our previous issues? See which articles your colleagues read most.

    Quantifying the risk of incompatible kidney transplantation: A multicenter study (American Journal of Transplantation)
Doctor performs 1st US robotic kidney transplants using a revolutionary cooling technique (HIT Consultant)
Long-term survival after simultaneous pancreas-kidney transplantation with primary function of at least 1 year: A single-center experience (Annals of Transplantation (login required)
Impact of repeat testing of living kidney donors within 14 days of the transplant procedure: A multicenter retrospective survey (Transplant Infectious Disease (login required)

Don't be left behind. Click here to see what else you missed.


 

ASTS NewsBrief
Colby Horton, Vice President of Publishing, 469.420.2601
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Esther Cho, Content Editor, 469.420.2671   
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