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Innate immune cell collaborations instigate transplant tolerance
American Journal of Transplantation
Total lymphoid irradiation (TLI), T cell depletion and donor bone marrow transplantation (BMT) consistently induces mixed chimerism and a state of donor-specific immunological tolerance to allografts in laboratory animals. The induction of a similar robust tolerant state clinically would remove the recipient's need for toxic immunosuppressants and provide freedom from acute and chronic rejection. Indeed, when comparable regimens are tried clinically, they have shown promise by inducing transplant tolerance in a subset of patients and often enable recipient tapering off immunosuppression. Yet there has been a failure to fully recapitulate the consistent and robust immunological tolerance observed experimentally.
Call for 2015 ASTS Council Nominations
Nominations are being accepted for councilor-at-large, treasurer, and president-elect positions for terms beginning in May 2015. The deadline is Nov. 12, 2014.
OPTN proposals for public comment, including HOPE Act requirements
The OPTN has published for public comment 18 proposals relating to policies and bylaws. Comments will be accepted through Dec. 5, 2014. Among these is the Proposal to Address the Requirements Outlined in the HIV Organ Policy Equity Act, which amends OPTN policies to allow members to participate in the research study in accordance with upcoming changes to the Final Rule and criteria developed by the Secretary of Health and Human Services (HHS).
ASTS history in your hands
The ASTS 40th anniversary book is full of pictures and fun facts about the Society, it's members and the field of transplantation. One free copy is available to ASTS members, and non-members can purchase a copy in the ASTS Store.
Case control study: Risk factors associated with acute heart failure during liver transplant surgery
Transplantation (login required)
Acute intraoperative heart failure (HF) is a rare but often fatal complication of liver transplant surgery. Little is known about the clinical course or predictive variables. The aims of this study were to provide a detailed clinical description and conduct a systematic search for characteristics associated with intraoperative HF.
Evaluation of graft stiffness using acoustic radiation force impulse imaging after living donor liver transplantation
Clinical Transplantation (login required)
Acoustic radiation force impulse (ARFI) imaging is an ultrasound-based modality to evaluate tissue stiffness using short-duration acoustic pulses in the region of interest. Virtual touch tissue quantification (VTTQ), which is an implementation of ARFI, allows quantitative assessment of tissue stiffness. Twenty recipients who underwent living donor liver transplantation (LDLT) for chronic liver diseases were enrolled.
Emotional well-being of living kidney donors: Findings from the RELIVE study
American Journal of Transplantation (login required)
Following kidney donation, short-term quality of life outcomes compare favorably to US normative data but long-term effects on mood are not known. In the Renal and Lung Living Donors Evaluation Study (RELIVE), records from donations performed 1963–2005 were reviewed for depression and antidepressant use predonation. Postdonation, in a cross-sectional cohort design 2010–2012, donors completed the Patient Health Questionnaire (PHQ-9) depression screening instrument, the Life Orientation Test-Revised, 36-Item Short Form Health Survey and donation experience questions.
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Immunization rates low among kidney transplant candidates
Immunization rates for common vaccine-preventable infections were low among kidney transplant candidates, according to data presented at IDWeek 2014. "The best time to vaccinate this population is before transplantation," Ankit Parikh, M.D., of Drexel University College of Medicine, Philadelphia, told Infectious Disease News. "If you vaccinate them, you can prevent post-transplant infections … if you do the right thing at the right time."
Pre-transplant donor HLA-specific antibodies: Characteristics causing detrimental effects on survival after lung transplantation
The Journal of Heart and Lung Transplantation
The impact of Luminex-detected HLA antibodies on outcomes after lung transplantation is unclear. Herein we have undertaken a retrospective study of pre-transplant sera from 425 lung transplants performed between 1991 and 2003. Pre-transplant sera, originally screened by complement-dependent cytotoxicity (CDC) assays, were retrospectively tested for the presence of HLA-specific antibodies using HLA-coated Luminex beads and C4d deposition on Luminex beads. The results were correlated with graft survival at 1 year.
Kidney transplant: Surgeons carry out first European keyhole kidney transplant
Surgeons at the Royal Liverpool Hospital have carried out a kidney transplant using keyhole surgery. It is the first time the procedure has been performed in Europe.
The technique, originally developed in India, offers patients the chance of a much faster recovery after the operation.
Normally a kidney transplant would involve serious open surgery and a sizeable incision to perform the transplant.
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