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Text Version   RSS   Unsubscribe   Archive   Media Kit                     April 30, 2015

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Welcome to the ICBS Discovery e-NewsBrief from the International Chemical Biology Society. This is a free, bi-weekly digest of headlines and news related to the chemical biology field. With a variety of stories selected from media outlets around the world, we hope you will find this publication informative. The e-NewsBrief will arrive in your email inbox every other Thursday.

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Breakthrough in 'editing' mitochondrial disease DNA
Medical News Today
Researchers from the Salk Institute for Biological Studies report success for the first time in using gene-editing technology to prevent multiple human mitochondrial diseases from being passed from female mice to their offspring. Mitochondria generate the majority of the energy used by cells, with each cell containing between 1,000 and 100,000 copies of mitochondrial DNA. Mitochondrial DNA is passed exclusively through maternal inheritance.
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Device weighs, images individual molecules
R&D Magazine
Building on their creation of the first-ever mechanical device that can measure the mass of individual molecules, one at a time, a team of Caltech scientists and their colleagues have created nanodevices that can also reveal their shape. Such information is crucial when trying to identify large protein molecules or complex assemblies of protein molecules. The paper describing the technology was published online in Nature Nanotechnology.
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Drugs that activate brain stem cells may reverse multiple sclerosis
National Institutes of Health
Two drugs already on the market — an antifungal and a steroid — may potentially take on new roles as treatments for multiple sclerosis. According to a study published in Nature, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis.
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Drug research enhanced by fragment screening libraries
Phys.Org
Generation of fragment screening libraries could enhance the analysis and application of natural products for medicinal chemistry and drug discovery, according to Griffith University's professor Ronald Quinn. He and other researchers proposed a novel approach to capturing the structural diversity of nature for medical research and implementation in a recent paper published in PLOS ONE.
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Final trial results of world's most advanced malaria vaccine published
Drug Discovery & Development
The first malaria vaccine candidate to reach phase three clinical testing is partially effective against clinical disease in young African children up to 4 years after vaccination, according to final trial data, published in The Lancet. The results suggest that the vaccine could prevent a substantial number of cases of clinical malaria, especially in areas of high transmission.
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Melanoma drug shows promise for treating advanced lung cancer
Medical News Today
A drug approved to treat melanoma has shown promise for the treatment of advanced nonsmall cell lung cancer, according to researchers from the University of California-Los Angeles. Nonsmall cell lung cancer is the most common form of lung cancer in the U.S., accounting for around 85 to 90 percent of all cases.
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Proton therapy technique brings hope of more effective treatment for tumors
Science Daily
Researchers have succeeded in making a model of breathing movement that allows for the precise measurement of narrow beams to a dummy tumor in the lung by simulating the motion and physical properties of the chest anatomy in a model, thereby taking a large step toward maximizing the targeting of treatment in mobile organs.
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Scientists identify key protein in immune response to allergies and worms
Medical News Today
Researchers have found a new way the body controls inflammation when it is responding to parasitic worm infections or during allergic reactions. The researchers report their work in the journal Nature Communications. They believe their findings will lead to new treatments for controlling inflammation during worm infections and allergic reactions such as asthma attacks.
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Parallel sequencing of DNA, RNA gives clues into secret world of cells
Science Daily
Researchers have developed a large-scale sequencing technique called Genome and Transcriptome Sequencing that reveals, simultaneously, the unique genome sequence of a single cell and the activity of genes within that single cell. The study, published Nature Methods, has experimentally established for the first time that when a cell loses or gains a copy of a chromosome during cell division, the genes in that particular region of DNA show decreased or increased expression.
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