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Text Version   RSS   Unsubscribe   Archive   Media Kit                     May 14, 2015

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Welcome to the ICBS Discovery e-NewsBrief from the International Chemical Biology Society. This is a free, bi-weekly digest of headlines and news related to the chemical biology field. With a variety of stories selected from media outlets around the world, we hope you will find this publication informative. The e-NewsBrief will arrive in your email inbox every other Thursday.

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A drug-resistant typhoid superbug is spreading worldwide, researchers say
TIME
A drug-resistant strain of typhoid fever is spreading worldwide, according to new research. A study published in Nature Genetics conducted by a team of 74 researchers in over 12 countries shows that antibiotic resistant typhoid, driven by one family of bacteria called H58, is spreading globally.
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Experts call for global research fund for Ebola, other neglected disease
The Guardian
The Ebola outbreak in Liberia, Guinea and Sierra Leone brought it home. For some deadly diseases, there are no drug treatments. Even doctors who were infected in west Africa and shipped back to the wealthy U.S. or Europe were given experimental medicines, because that is all there is. This situation has been known and deplored by medicines campaigners for many years.
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Proteomics identifies DNA repair toolbox
R&D Magazine
During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication machinery gets stuck? To answer this question, scientists have analyzed how the protein composition of the DNA replication machinery changes upon encountering damaged DNA.
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One gene closer to helping sufferers of rare genetic disorder
Medical Xpress
A new study has separately confirmed and significantly built on recent research, identifying mutations of a gene that causes the uncommon but potentially fatal Adams-Oliver syndrome. A leading team of medical and genetics experts from institutions across Europe independently identified a gene called NOTCH1 while also discovering the largest range of mutations, both consolidating and expanding previous research published in 2014. The findings were published in Circulation: Cardiovascular Genetics.
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Maple syrup: New way to fight antibiotic-resistant bacteria?
The Wall Street Journal
Maple syrup may help fight disease-causing bacteria, including antibiotic-resistant strains that often grow in health-care settings, says a study published online in Applied and Environmental Microbiology. Concentrated extracts of maple syrup combined with antibiotics significantly reduced the growth of four common bacterial strains and bacterial communities called biofilms, the study found.
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New malaria vaccine shows promise in field trial
Medical Xpress
A vaccine against malaria, developed at Oxford University's Jenner Institute, has shown promising results in its first field trial. The results are published in journal Science Translational Medicine. Following a trial in Kenya, the vaccine was found to be 67 percent effective against infection with Plasmodium falciparum, one of the parasites known to cause malaria.
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DNA 'printing' a big boon to research, but some raise concerns
National Public Radio
Here's something that might sound strange: There are companies now that print and sell DNA. This trend — which uses the term "print" in the sense of making a bunch of copies speedily — is making particular stretches of DNA much cheaper and easier to obtain than ever before. That excites many scientists who are keen to use these tailored strings of genetic instructions to do all sorts of things, ranging from finding new medical treatments to genetically engineering better crops.
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Gene found that is essential to maintaining breast and cancer stem cells
Medical Xpress
The gene and hormone soup that enables women to breastfeed their newborns also can be a recipe for breast cancer, particularly when the first pregnancy is after age 30. Researchers have now found that the gene DNMT1 is essential to maintaining mammary stem cells that enable normal rapid growth of the breasts during pregnancy, as well as the cancer stem cells that may enable breast cancer. They've learned that the DNMT1 gene also is highly expressed in the most common types of breast cancer.
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A 'super cool' way to deliver drugs
R&D Magazine
Water, when cooled below 32 degrees Fahrenheit, eventually freezes. But some substances, when they undergo a process called "rapid freezing" or "supercooling," remain in liquid form — even at below-freezing temperatures. The supercooling phenomenon has been studied for its possible applications in a wide spectrum of fields. A new study published in Scientific Reports is the first to break down the rules governing the complex process of crystallization through rapid cooling.
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Colby Horton, Vice President of Publishing, 469.420.2601
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