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Text Version   RSS   Unsubscribe   Archive   Media Kit                     August 21, 2014

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Welcome to the ICBS Discovery e-NewsBrief from the International Chemical Biology Society. This is a free, bi-weekly digest of headlines and news related to the chemical biology field. With a variety of stories selected from media outlets around the world, we hope you will find this publication informative. The e-NewsBrief will arrive in your email inbox every other Thursday.

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New mouse model points to therapy for liver disease
Science Daily
A novel mouse model that closely resembles human NASH has been described by researchers. They use it to demonstrate that interference with a key inflammatory protein inhibits both the development of NASH and its progression to liver cancer.
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Researchers reveal weakness in defenses of deadly brain tumor
Neuroscience News
Glioblastoma is a complex, deadly and hard-to-treat brain cancer, but Yale School of Medicine researchers may have found the tumor's Achilles heel. The researchers report in the Aug. 12 issue of the journal Science Signaling that targeting a protein crucial in the early development of the brain can block multiple signaling pathways implicated in glioblastoma growth. The approach also reduced human tumors in mouse models of the disease.
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Do gut bacteria rule our minds?
Neuroscience News
It sounds like science fiction, but it seems that bacteria within us — which outnumber our own cells about 100-fold — may very well be affecting both our cravings and moods to get us to eat what they want, and often are driving us toward obesity. In a recent article published in the journal BioEssays, researchers concluded from a review of the recent scientific literature that microbes influence human eating behavior and dietary choices to favor consumption of the particular nutrients they grow best on, rather than simply passively living off whatever nutrients we choose to send their way.
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New thinking needed for superbug treatments
By Mike Wokasch
Not a day goes by without reading or hearing about the seemingly impossible task of finding effective new treatments against "superbugs" that are resistant to existing drugs. The dearth of prospects for treating these superbugs is often blamed on the lack of investment and market economics. Sure, more investment-friendly healthcare market opportunities might lure additional pharma companies and money to the effort, but there is an even bigger factor standing in the way of conquering this medical dilemma.
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Radiolabels help evaluate emerging cancer treatment
Chemistry World
Researchers in Spain have come up with a way to track the biodistribution of a boron cluster complex used to prepare boron-carrier drugs for a prospectvie cancer treatment called boron neutron capture therapy. Drugs based on the boron cluster complex COSAN exploit the overexpression of membrane receptors in cancer cells to deliver therapeutic levels of 10B across the membrane.
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Worm virus details come to light
R&D Magazine
Rice University scientists have won a race to find the crystal structure of the first virus known to infect the most abundant animal on Earth. The Rice laboratories of structural biologist Yizhi Jane Tao and geneticist Weiwei Zhong, with help from researchers at Baylor College of Medicine and Washington University, analyzed the Orsay virus that naturally infects a certain type of nematode, the worms that make up 80 percent of the living animal population.
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New small molecules target mutation and a form of dementia
Medical News Today
For the first time, researchers have successfully constructed a strategy targeting a specific genetic mutation that causes amyotrophic lateral sclerosis and a type of dementia. And the exciting news is that their findings show it may be possible to treat a large number of patients who have these two diseases.
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ICBS Discovery
Colby Horton, Vice President of Publishing, 469.420.2601
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