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Welcome to the ICBS Discovery e-NewsBrief from the International Chemical Biology Society. This is a free, bi-weekly digest of headlines and news related to the chemical biology field. With a variety of stories selected from media outlets around the world, we hope you will find this publication informative. The e-NewsBrief will arrive in your email inbox every other Thursday.
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MS drug candidate also shows promise for ulcerative colitis
Positive new clinical data was recently released on a drug candidate for ulcerative colitis that was first discovered and synthesized at The Scripps Research Institute. According to results from a Phase 2 study of 199 patients with active, moderate to severe disease, the drug candidate RPC1063 has potential to significantly improve the treatment paradigm for ulcerative colitis patients.
Close link between Down syndrome, Alzheimer's unlocked by researchers
Alzheimer's News Today
A study published online in Cell Reports reveals common molecular mechanisms between Down syndrome and Alzheimer's disease, with clear implications for the development of therapeutics against neurodisorder diseases. Down syndrome, or trisomy 21 patients — who carry an extra copy of the 21 chromosome — have an increased risk of developing Alzheimer's disease.
Team discovers how microbes build a powerful antibiotic
Researchers report in the journal Nature that they have made a breakthrough in understanding how a powerful antibiotic agent is made in nature. Their discovery solves a decades-old mystery, and opens up new avenues of research into thousands of similar molecules, many of which are likely to be medically useful.
New test reduces trial-and-error process for mental health drugs
By Rachael Mattice
Picking up a prescription from the pharmacy always includes general warnings. When it comes to more complex medications that are used to treat mental health disorders — such as antidepressants or antipsychotics — a patient can expect a printout of warning labels with possible adverse effects that are dangerous and symptomatically worse than the condition being initially treated. Substantial advances have been made in the field of genomic medicine since the decoding of the human genome in 2001. One such advance is known as pharmacogenetic testing.
Researchers discover leukemia's hiding places
In patients with leukemia, cancer cells can embed within the walls of blood vessels and hide from chemotherapy, according to a University of Florida study published in the Oct. 8 edition of the journal Leukemia. Now, University of Florida researchers are using a two-year, $800,000 grant from the Leukemia and Lymphoma Society to screen for new drugs that disrupt the tight-knit relationship between leukemia cells and blood vessels.
Colorado State University to develop Ebola vaccine
The Denver Post
Colorado State University has been awarded $2 million by the U.S. Department of Defense to begin developing and manufacturing an Ebola vaccine, officials said. The university's Biopharmaceutical Manufacturing and Academic Resource Center, started in 2006, was selected in July to help the defense department's research in creating a vaccine for use in human clinical trials.
New hope in treating African sleeping sickness
In early drug discovery, you need a starting point, says Northeastern University professor Michael Pollastri. In a new research paper published in PLOS-Neglected Tropical Diseases, Pollastri and his colleagues present hundreds of such starting points for potentially treating Human African trypanosomiasis, or sleeping sickness, a deadly disease that affects thousands of people annually.
Insight into how cells copy chromosomes important for fighting cancer
Medical News Today
As we find out more and more about what goes wrong inside cells, the better we become at killing cancer without harming the rest of the body. Now, scientists have discovered a key step in how cells copy their chromosomes when they divide that promises to be useful for cancer research. Researchers report how they solved an important mystery in cell biology in the journal Science.
Drug wipes out lung cancer in mice with minimal side effects
One experimental drug shows early signs of killing cancer cells in the body while leaving everything else alone, according to a paper published in the journal Science Translational Medicine. The drug, called OTS964, completely eliminated aggressive human lung cancer tumors in five out of six mice without major side effects, University of Chicago researchers report.
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