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Hormone replacement therapy may increase ovarian cancer risk
Medscape (Free login required)
Hormone replacement therapy (HRT) was significantly associated with an increased risk for ovarian cancer in postmenopausal women, according to an extensive meta-analysis from the Collaborative Group on Epidemiological Studies of Ovarian Cancer. "The findings that ovarian cancer risk is greatest in current users of hormone therapy, falls after use ceases, and varies by tumour type, strongly suggest a causal relationship," the researchers write.
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SGO NEWS


Featured guests and speakers at the SGO Annual Meeting
The SGO Annual Meeting on Women's Cancer in Chicago on March 28-31 will have a number of featured guests and speakers to address some of the top issues that impact health care providers today, from “Leadership Under Pressure and Flexible Thinking” with Bruce Craven to the “Gyn Onc Wellness Retreat” with Kell Julliard. Register today through sgo.org.
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OVARIAN CANCER


FDA grants Reolysin orphan drug designation for ovarian cancer
OncLive
The FDA has granted an orphan drug designation to Reolysin (wild-type reovirus) for the treatment of patients with ovarian cancer, according to the developer of the immunotherapy, Oncolytics Biotech, Inc. Reolysin is currently being studied in an ongoing randomized phase II trial (GOG186H) in combination with weekly paclitaxel versus weekly paclitaxel alone in patients with persistent or recurrent ovarian, fallopian tube or primary peritoneal cancer. The trial completed enrollment in September 2014.
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CERVICAL CANCER


Study: Doctors' assumptions on sex heighten lesbians' cervical cancer risk
Reuters
Lesbians may be at higher risk of cervical cancer because they get fewer screenings than heterosexual women, due partly to doctors' sometimes incorrect assumptions about their sexual history, University of Washington researchers said. Although nearly all cases of cervical cancer are attributable to a human papillomavirus, or HPV, infection, healthcare providers often do not encourage lesbian patients to get regular HPV screenings, the researchers found. That is because the disease is most commonly transmitted during heterosexual sex and doctors may wrongly assume lesbians have only had sex with other women, despite studies that have found most lesbians and their partners have had sex with men, according to the study published in The Nurse Practitioner.
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Many women willing to extend cervical cancer screening intervals
Cancer Network
Women in routine gynecologic care expressed willingness to extend intervals between screenings to a certain extent, and to use cytology alone or Pap-Human Papillomavirus (HPV) cotesting if recommended by a physician, according to a new survey. “HPV cotesting with a 3-year screening interval has been an acceptable option since 2003, yet uptake of cotesting in clinical practice has been slow,” wrote researchers led by Patti E. Gravitt, PhD, MS, of the University of New Mexico in Albuquerque. She and colleagues conducted a survey of 551 women aged 36 to 62 who were enrolled in the Human Papillomavirus in Perimenopause Study to assess attitudes toward new cervical cancer screening options. Results were published in the February issue of Obstetrics & Gynecology.
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Ability to conceive not threatened by cervical treatment
MedPage Today
A woman's ability to conceive did not change following procedures to evaluate and treat cervical abnormalities, a large cohort study showed. Women who received surgical treatment actually had a 42 percent higher pregnancy rate compared with women who did not undergo cervical treatment or diagnostic procedures. The pregnancy rate was similar between women who had treatment or diagnostic procedures. The findings published in PLoS One should go a long way toward resolving longstanding uncertainty about possible adverse effects of cervical procedures on pregnancy, reported Allison Naleway, PhD, of Kaiser Permanente Northwest, in Portland, Oregon, and colleagues.
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BREAST CANCER


Researchers suggest new therapy for BRCA-related tumors
Breast Cancer News
According to a study published in Nature, BRCA1 and BRCA2 genes are known to produce tumor suppressor proteins that help repair damaged DNA, ensuring the integrity of the genetic material. When one or both of these genes suffer mutations, their encoding protein may no longer be produced or have its function compromised, potentially resulting in a defective DNA repair mechanism and increased risk for genetic alterations that may lead to cancer. It is well-known that if a woman inherits specific mutations in the BRCA1 or BRCA2 genes, her risk for developing breast and/or ovarian cancer is greatly increased.
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Model improves prediction of breast cancer risk after benign biopsy
Healio
A model that consisted of demographic and histologic features more accurately reflected a woman’s risk for breast cancer after receipt of a benign biopsy than the Breast Cancer Risk Assessment Tool, according to study results published in the Journal of Clinical Oncology. “Physicians routinely perform biopsies to evaluate concerning findings in the breast, either felt on exam or seen on mammogram, for the presence of a breast cancer,” researcher Amy Degnim, MD, a surgeon at Mayo Clinic in Rochester, Minnesota, said in a press release. “However, about three-quarters of these biopsies prove to be benign and are referred to as benign breast disease.”
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Women's Cancer News
Colby Horton, Vice President of Publishing, 469.420.2601
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Jessica Taylor, Senior Medical Editor, 202-684-7169  
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