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Mixed results for bevacizumab plus chemo in ovarian cancer
MedPage Today
Women with recurrent, platinum-sensitive ovarian cancer obtained an unprecedented survival benefit with a chemotherapy-bevacizumab (Avastin) combination, but the improvement still failed to achieve statistical significance. Patients who received carboplatin, paclitaxel, and bevacizumab had a median overall survival (OS) of 42.2 months compared with 37.3 months for platinum-taxane doublet. Nonetheless, the 5-month difference just missed the trial's cutoff for statistical significance. Bevacizumab-treated patients did have a statistically significant improvement in progression-free survival (PFS), a secondary endpoint, as reported at the Society of Gynecologic Oncology meeting.
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SGO NEWS


Record-breaking numbers for 2015 SGO Annual Meeting
SGO reached the 2,000-member milestone during this week’s Annual Meeting on Women’s Cancer in Chicago, and broke a meeting registration record with 2,064 attendees. Enjoy conference photos and mark your calendar for the 47th Annual Meeting from March 19 through 22, 2016, in San Diego, CA.
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OVARIAN CANCER


Ovarian cancer treatment set to improve following biomarker discovery
Medical News Today
Resistance to chemotherapy is a major reason that patients with the most malignant form of ovarian cancer do not have a good chance of survival. Now researchers have discovered a biomarker that should improve prospects for patients by indicating how their bodies are likely to react to chemotherapy. The researchers, who report their findings in the British Journal of Cancer, suggest the discovery of the biomarker could lead to better treatment options for patients with high-grade serous ovarian cancer (HGSC).
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ENDOMETRIAL CANCER


Guidance issued for endometrial cancer, hints for diagnosis
Medscape (Free login required)
The American College of Obstetricians and Gynecologists and the Society of Gynecologic Oncology have issued new guidance for endometrial cancer. The practice bulletin was published in the April issue of Obstetrics & Gynecology. "A thorough understanding of the epidemiology, pathophysiology, and diagnostic and management strategies for this type of cancer allows the obstetrician–gynecologist to identify women at increased risk, contribute toward risk reduction, and facilitate early diagnosis," the bulletin states.
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CERVICAL CANCER


Carboplatin noninferior to cisplatin for metastatic, recurrent cervical cancer
Healio
Carboplatin-based chemotherapy should be a standard treatment option for metastatic or recurrent cervical cancer, according to findings from a randomized phase 3 trial. Palliative chemotherapy is an option for women with metastatic or recurrent cervical cancer. Cisplatin has been the active agent most often used in that setting. Combining cisplatin with paclitaxel has vastly improved response rate and PFS while maintaining a tolerable level of toxicity, according to study background published in the Journal of Clinical Oncology.
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Female IBD patients should monitor cervical cancer screenings
HCPLive
Women afflicted with inflammatory bowel disease (IBD) are at higher risk for cervical dysplasia and cancer. A new study published in Clinical Gastroenterology and Hepatology, underscored the significance for female IBD patients and their physicians to cautiously follow the recommended cervical cancer screening guidelines. The research team conducted a population-based, case-controlled study enrolling a total of 27,408 women with IBD in Denmark, during 35-year period.
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MORCELLATION


Fibroid morcellation gets boost from new study but procedure was linked to more leiomyosarcoma deaths
MedPage Today
A decision-tree analysis predicted fewer overall deaths, fewer surgical complications, and increased quality of life for women who underwent laparoscopic hysterectomy with morcellation compared with abdominal hysterectomy for presumed fibroid uterus, reported researchers. But there were more deaths from leiomyosarcoma after laparoscopic hysterectomy, wrote Matthew Siedhoff, MD, an ob/gyn physician at the University of North Carolina School of Medicine in Chapel Hill, and colleagues, in the American Journal of Obstetrics & Gynecology.
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HEALTH POLICY


The birth and increasingly troubled life of Medicare
MedPage Today
On July 30, 1965, an 81-year-old Missourian proudly accepted the nation's first Medicare card. Former President Harry S. Truman was awarded this honor by his greatest admirer, President Lyndon B. Johnson. Johnson had been a young Texas congressman when Truman first proposed a national health insurance plan in 1945. Faced by implacable congressional opposition led by most Republicans and several conservative Democrats, national health insurance never had a chance and had disappeared ignominiously from national consideration even before Truman left office in 1952.
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RESEARCH


Cancer whole-genome sequencing: Present and future
Oncogene
Recent explosive advances in next-generation sequencing technology and computational approaches to massive data enable us to analyze a number of cancer genome profiles by whole-genome sequencing (WGS). To explore cancer genomic alterations and their diversity comprehensively, global and local cancer genome-sequencing projects, including ICGC and TCGA, have been analyzing many types of cancer genomes mainly by exome sequencing.
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Women's Cancer News
Colby Horton, Vice President of Publishing, 469.420.2601
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Jessica Taylor, Senior Medical Editor, 202-684-7169  
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