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Review identifies modifiers of cancer risk in BRCA1/2 carriers
HealthDay News via Healthcare Professionals Network
Modifiers of cancer risk have been identified for BRCA1/2 mutation carriers, according to a review published online May 13 in the Journal of the National Cancer Institute. Tara M. Friebel, MPH, from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues conducted a systematic review of the literature to identify factors that are associated with cancer risk modification in BRCA1/2 mutation carriers. Forty-four non-overlapping studies that met predefined quality criteria were included in fixed effects meta-analyses.
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The 'MacGyver Cure' for cancer
The New York Times
Thanks to early detection (and helped by the vaccine for HPV, or human papillomavirus), the mortality rate for cervical cancer in the U.S. is relatively low. Not so in developing countries, where it kills almost 250,000 women every year. Haiti has one of the highest rates of cervical cancer in the world. Here is how one doctor developed a way to screen Haitian women for cervical cancer using methods that were “very Haitian, where people solve problems in creative ways.”
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TGen-led study discovers genetic cause of rare ovarian cancer
Arizona Capital Times
An international research team led by the Translational Genomics Research Institute (TGen) recently found the cause of a rare type of ovarian cancer that most often strikes girls and young women. The findings — published in the prestigious scientific journal Nature Genetics — revealed a “genetic superhighway” mutation in a gene found in the overwhelming majority of patients with small cell carcinoma of the ovary, hypercalcemic type, also known as SCCOHT.
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  ChemoFx Improves Ovarian Cancer Outcomes
ChemoFx® provides invaluable information to physicians choosing from 20+ equivalent treatment recommendations without prior knowledge of how individual patients may respond. ChemoFx determines platinum resistance in primary ovarian cancer and demonstrates longer overall survival by 14 months in recurrent ovarian cancer, making it instrumental in improving patient outcomes.


Over two-thirds of Americans harbor HPV, genomics study reveals
Medscape (Free login required)
More than two thirds of healthy U.S. residents harbor at least one type of human papillomavirus (HPV), most of which are undetectable by widely used commercial screening kits, a large genetic analysis shows. However, the relevance of this is at present unclear, commented an expert not connected with the study. The study identified 109 different HPV types in tissue samples taken from 103 men and women whose tissue DNA was made available through the National Institutes of Health (NIH) Human Microbiome Project.
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FDA advisory on surgical device divides doctors
The Wall Street Journal (Subscription required)
An advisory from the Food and Drug Administration that strongly cautioned doctors against performing a common surgical procedure on women is upending the landscape of gynecological care across the U.S. The FDA surprised gynecologists last month when it issued an advisory against using a device called a laparoscopic power morcellator, saying it can spread a dangerous hidden cancer.
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Contralateral prophylactic mastectomy often used unnecessarily
Healio — HemOnc Today
Fear of recurrence drove many women with breast cancer to consider or undergo contralateral prophylactic mastectomy even when they were not at significant risk for contralateral occurrence, according to an analysis of SEER data. “Women appear to be using worry over cancer recurrence to choose contralateral prophylactic mastectomy,” researcher Sarah Hawley, Ph.D., MPH, associate professor of internal medicine at the University of Michigan Medical School, said in a press release.
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What's hot at the ASCO Annual Meeting this year?
Medscape (Free login required)
Although it's still a week away, there is already a lot of buzz about the forthcoming 2014 Annual Meeting of the American Society of Clinical Oncology® (ASCO). Some of it is speculation about data that have already been released in abstract form online. This early abstract release always stirs up a frenzy of media and financial analyst reports, creating a hype about the meeting long before it starts, but ASCO holds back some of the most important data and releases them only at the meeting.
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