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Research by Rudy Valentine and colleagues at the University of Illinois

They reported on 127 sedentary older men and women in this cross-sectional study. The article soon will appear in Brain, Behavior, and Immunity (in press). Women reported 63 percent greater fatigue than did men, with incremental effects directly related to their adiposity. Adiposity also was directly associated with C-reactive protein (systemic inflammation) in the women but not the men, while depression was more strongly related to fatigue among the men. Acknowledging the complexity of physiologic and psychologic interactions that may affect perceptions of fatigue, the authors concluded that these factors merit further study in interventions aimed at improving health for older women vs. men.


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