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Free the radicals for better wound healing
Genetic Engineering & Biotechnology News
Long assumed to be destructive to tissues and cells, "free radicals" generated by the cell's mitochondria — the energy producing structures in the cell — are actually beneficial to healing wounds. That's the conclusion of biologists at University of California San Diego who discovered that "reactive oxygen species" are necessary for the proper healing of skin wounds in the laboratory roundworm C. elegans.
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Amino acids help diabetic foot wounds
Researchers at University of Nevada School of Medicine in Las Vegas reviews previous studies and find supplementation with certain amino acids can help diabetic foot wounds.
Surface acoustic wave patch therapy affects tissue oxygenation in ischemic feet
Transcutaneous oxygen pressure less than 30 mm Hg at the toe leads to local tissue hypoxia and nonhealing wounds. Studies regularly illustrate that TcPO2 values are strong predictors of healing and can accurately demonstrate altered levels when extremities have restricted blood flow.
The objective of this study was to evaluate the effectiveness of surface acoustic wave in ischemic feet on local tissue oxygenation.
'Diabetic foot ulcers can be treated without surgery'
The Times of India
Diabetics with foot ulcers need not always go for amputation, as medication along with balloon angioplasty that opens up the affected blood vessels, can effectively treat these ulcers. Interventional radiologist Dr Vimal Someshwar told The Times of India on the sidelines of a national endovascular workshop, that amputation is the result of many poor habits and lack of preventative action.
The specific receptor targeted by naltrexone to enhance diabetic wound closure is OGFr
Society for Experimental Biology and Medicine via Medical Xpress
A major complication associated with diabetes is delayed cell replication in epithelium and skin. Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, have reported the presence and function of the opioid growth factor (OGF) and its nuclear-associated receptor (OGFr) in skin. OGF, an inhibitory growth factor, chemically termed [Met5]-enkephalin, can be upregulated in diabetes leading to depressed cell proliferation.
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Smart bandage warns of wound-healing problems
Chemistry World via Scientific American
A group of researchers from the U.S., South Korea and Germany has developed a liquid bandage that can map oxygen concentrations in skin wounds and burns. Damaged tissue requires a good blood supply to provide the regenerating cells with glucose and oxygen. Lack of either can lead to chronic sores, which means measuring oxygen levels is essential for wound treatment.
Researchers to build wearable interface to make prosthetics more comfortable
University of Texas at Arlington via Medical Xpress
University of Texas Arlington researchers have been awarded a $744,300 grant from the Department of Defense Peer Reviewed Orthapaedic Research Program to create an adaptive interface that fits between a prosthetic and a patient's limb so that the fit and comfort of the prosthetic are improved.
Open tibial fractures grade IIIC treated successfully with external fixation, negative-pressure wound therapy and recombinant human bone morphogenetic protein 7
The aim of the therapy in open tibial fractures grade III was to cover the bone with soft tissue and achieve healed fracture without persistent infection. Open tibial fractures grade IIIC with massive soft tissue damage require combined orthopaedic, vascular and plastic–reconstructive procedures. Ilizarov external fixator combined with application of recombinant human bone morphogenetic protein–7 at the site of delayed union enhanced definitive bone healing within 16–18 months.
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