ASCLS eNewsBytes
Apr. 21, 2015

Genetic variability may help predict tumor aggressiveness and treatment success
Medical News Today
A new scoring method that measures the genetic variability in a tumor may one day help identify patients with aggressive cancers that are less likely to respond to therapy. Such a tool could improve clinical decisions based on the unique characteristics of a patient's cancer.More

Syrup extract found to make antibiotics more effective against bacteria
McGill University via Infection Control Today
A concentrated extract of maple syrup makes disease-causing bacteria more susceptible to antibiotics, according to laboratory experiments by researchers at McGill University. The findings, which will be published in the journal Applied and Environmental Microbiology, suggest that combining maple syrup extract with common antibiotics could increase the microbes' susceptibility, leading to lower antibiotic usage. More

New laboratory technique reveals structure and function of proteins critical in DNA repair
University of Illinois College of Engineering via ScienceDaily
By combining two highly innovative experimental techniques, scientists have for the first time simultaneously observed the structure and the correlated function of specific proteins critical in the repair of DNA, providing definitive answers to some highly debated questions, and opening up new avenues of inquiry and exciting new possibilities for biological engineering. More

Shape-shifting molecule tricks viruses into mutating themselves to death
Lab Manager
A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by which an anti-HIV drug induces lethal mutations in the virus' genetic material. The findings from the University of Chicago and the Massachusetts Institute of Technology could bolster efforts to develop the next generation of anti-viral treatments. More

Studies show how clinical whole-exome sequencing may forever change the future practice of medicine while giving pathologists a new opportunity to deliver value
DARK Daily
In recent years, pathologists and other clinical laboratory professionals have seen increasing evidence of the benefits of using exome sequencing for clinical diagnostic purposes. Confirming their initial published findings of a 25 percent molecular diagnostic rate, researchers from Baylor College of Medicine, Baylor Human Genome Center and the University of Texas Health Science Center at Houston have released results of a large sampling of 2,000 consecutive patients. More

Ebola whole virus vaccine shown effective, safe in primates
Health Canal
An Ebola whole virus vaccine, constructed using a novel experimental platform, has been shown to effectively protect monkeys exposed to the often fatal virus. The vaccine, described in the journal Science, was developed by a group led by Yoshihiro Kawaoka, a University of Wisconsin-Madison expert on avian influenza, Ebola and other viruses of medical importance.More

Gene variation could spur longer smoking, earlier cancer
Washington University School of Medicine in St. Louis via HealthDay News
A gene variation associated with smoking longer and getting lung cancer at a younger age has been identified by researchers. People usually are screened for lung cancer based on how much they smoke and their age, the researchers said. But this new study supports the idea of using genetic information to target people who might not be screened otherwise, said study first author Dr. Li-Shiun Chen, of Washington University School of Medicine in St. Louis.More

At least 120 now infected in Indiana HIV outbreak
The number of people infected in southeastern Indiana's HIV outbreak has grown to at least 120, up by more than 20 recently, the state health department said. Another 10 infections are awaiting confirmation.More