ASCLS eNewsBytes
May. 1, 2012

Scientists identify diagnostic, therapeutic target for pancreatic cancer
Genetic Engineering News
Scientists have identified a tumor suppressor gene in pancreatic ductal adenocarcinoma (PDA), which they claim may represent a novel therapeutic target and biomarker of disease prognosis. The gene, known as USp9x, hasn't previously been linked with PDA or other types of carcinoma in either humans or mouse models. The discovery is reported by a team led by researchers at Cancer Research U.K.'s Cambridge Research Institute, who used Sleeping Beauty transposon-mediated insertional mutagenesis in a mouse model of pancreatic ductal preneoplasia to identify genes that cooperate with KrasG12D to promote tumorigenesis and cancer progression.More

Advances in HIV testing: What clinicians need to know
CDC vis Medscape Medical News
Dr. Philip J. Peters, a medical officer with the Division of HIV/AIDS Prevention, U.S. Centers for Disease Control and Prevention, reveals advances in HIV testing technology. The U.S. Food and Drug Administration has approved a new class of HIV test called the "combination HIV antigen/antibody test," also referred to as a "fourth-generation HIV immunoassay." This test detects HIV infection sooner than the traditional HIV antibody assay.More

USDA: US mad cow was lame, lying down at dairy
The Associated Press via USA Today
The mad cow that was recently discovered through routine testing in California had been euthanized after it became lame and started lying down at a dairy, federal officials revealed. The U.S. Department of Agriculture also said the cow was 10 years and seven months old in its update on the fourth case of mad cow disease ever discovered in the U.S.More

Rapid progress in systems biology predicted to increase multiplex testing by clinical pathology laboratories
Dark Daily
Trend from reductionism to holistic biomedicine means clinical laboratories and pathologists should expect increased multiplex testing. Systems biology is a rapidly-evolving area of research that, by itself, could greatly expand the need for multiplex testing performed by clinical laboratories. But systems biology has yet to catch the full attention of either the media or Wall Street. More

Advanced atherosclerosis: The heart and beyond
Medscape Medical News
When evaluating patients for cardiac risk, is a simple test for low-density-lipoprotein and high-density-lipoprotein cholesterol sufficient? Opinions on that question, along with how to treat established coronary artery disease, vary considerably. Controversial findings from a recent landmark clinical trial highlight some of those differences in opinion. More

Out with the old — Updating and redesigning a 40-year old laboratory
Advance for Medical Laboratory Professionals
Taking a 40 year old lab, bursting at the seams with equipment, and redesigning it with no additional space proves challenging at best. Although it is a tedious process, with a little ingenuity and input from coworkers, we are finding that we can come up with several creative options.More

More doctors using dashboards with real-time patient data — including clinical pathology laboratory test results
Dark Daily
Just as more clinical laboratories are using real-time dashboards to manage operations and workflow, a similar trend is happening with office-based physicians. Physicians using electronic medical records in their medical practice are creating dashboards that give them detailed, real-time information about their patients. More

Low-dose CT for appendicitis matches standard-dose technique
Medscape Medical News
Low-dose abdominal computed tomography (CT) can match the performance of a standard-dose CT protocol in its ability to rule out appendicitis while reducing patient exposure to ionizing radiation by 25 percent, according a Korean study published in the New England Journal of Medicine. Kyuseok Kim, MD, and colleagues at Seoul National University Bundang Hospital demonstrated that low-dose CT protocol is noninferior to standard-dose CT in guiding physicians to avoid performing unnecessary appendectomies on young adults.More

Studies show how cells decipher disease-causing invaders
Bioscience Technology
The specific mechanisms by which humans and other animals are able to discriminate between disease-causing microbes and innocuous ones in order to rapidly respond to infections have long been a mystery to scientists. But a study conducted on roundworms at the University of California, San Diego has uncovered important clues to answering that question.More

Anti-inflammatory factors fight bugs
The Scientist
Specialized compounds that naturally reduce inflammation in mice also help clear bacterial infections. A combination of these inflammation-resolving factors and antibiotics lowers the antibiotic dose needed to clear E. coli and Staphylococcus, according to a new paper in Nature. The finding suggests it would be possible to stimulate a person's own defenses to enhance the effects of antibiotics — a potentially valuable weapon in the fight against increasing rates of antibiotic resistance. More

Managing chemical inventory
Lab Manager Magazine
Nowadays very little if anything in the lab is more than five years old. From analytical instruments to laboratory software, the tools the lab uses need to be replaced with new tools that leverage the latest technology in order for the lab to stay competitive and compliant. The replacement of paper lab notebooks with personal computers and now with electronic lab notebooks, for instance, shows the steady influence of enabling technology in driving change.More

Researchers up the ante with development of woven blood vessels
Science Codex
A lot of people were skeptical when two young California-based researchers set out more than a decade ago to create a completely human-derived alternative to the synthetic blood vessels commonly used in dialysis patients. Since then, they've done that and more.More

Tiny reader makes fast, cheap DNA sequencing feasible
Advance for Medical Laboratory Professionals
Researchers have devised a nanoscale sensor to electronically read the sequence of a single DNA molecule, a technique that is fast and inexpensive and could make DNA sequencing widely available. The technique could lead to affordable personalized medicine, potentially revealing predispositions for afflictions such as cancer, diabetes or addiction.More