ASCLS eNewsBytes
Jun. 2, 2015

Large ovarian cancer study reveals new clues on genetics of chemoresistance
Medical News Today
A large study of the genetic mechanisms of chemoresistance in high-grade serous ovarian carcinoma reveals new clues on why the deadliest and most common form of ovarian cancer so often returns after initially successful chemotherapy. Resistance to chemotherapy is a major factor in the poor survival rate of women who develop high-grade serous ovarian carcinoma, the most malignant form of ovarian cancer.More

Harvard researchers demonstrate a new method to deliver gene-editing proteins into cells, possibly creating a new diagnostic opportunity for pathologists
DARK Daily
Researchers at Harvard University have demonstrated a new method to deliver gene-editing proteins into cells. This breakthrough could eventually trigger a demand for pathologists to do genetic analysis as the companion diagnostic needed to help clinicians select appropriate gene-editing therapies for their patients.More

Future vaccine may help lower blood pressure long-term
Health Canal
A DNA vaccine helped lower blood pressure for up to six months and reduced tissue damage to the heart and blood vessels associated with hypertension in rats. If future research shows the vaccine is a viable treatment option in humans, it could improve high blood pressure levels. More

ASCLS Annual Meeting, Clinical Lab Expo and Advanced Management Institute: Don't miss the hottest conferences this summer!
ASCLS
And hot it will be indeed! Join us this summer in Atlanta for the ASCLS Annual Meeting, Clinical Lab Expo and Advanced Management Institute. The AMI will be held July 26-27, and the ASCLS Annual Meeting and Clinical Lab Expo will be held July 28-Aug. 1. Register now. Early registration ends June 8. For more information, visit www.ascls.org/annualmeeting.More

Antibiotic approved for treating infant abdominal infections
National Institutes of Health via Infection Control Today
The antibiotic meropenem was approved by the Food and Drug Administration for treating abdominal infections in children less than 3 months of age. The approval came after a study by a National Institutes of Health research network evaluated the drug in treating children in this age group.More

Global trial: HIV drugs should be taken right after diagnosis
HealthDay News
People with HIV should start taking medications to battle the virus that causes AIDS as soon as they're diagnosed, a new international study finds. Scientists involved in the trial were so impressed by the health benefits of early use of HIV drugs that they shut the study down early so they could offer the medications to all participants.More

Researchers oppose unvalidated gene panel tests for cancer links
Reuters
A group of international researchers is making the case that genetic tests that look for multiple hereditary genes suspected of being linked to breast cancer should not be offered until they are proven to be valid and useful in clinical practice. Such tests, made by several companies including Myriad Genetics Inc., Ambry Genetics, Invitae and Illumina Inc., cover up to 100 inherited cancer genes, including more than 20 for breast cancer.More

Researchers discover surprisingly wide variation across species in genetic systems that influence aging
Lab Manager
The research sets the stage for an improved understanding of metabolism, growth and aging and may have implications for medicine and human health, said Anne Bronikowski, an associate professor of ecology, evolution and organismal biology and a lead author of the study. Insulin signaling is a critical biological process that governs the rate at which cells grow and divide and ultimately regulates aging. More

Genetic testing is flawed
The Associated Press via Laboratory Equipment
The first report from a big public-private project to improve genetic testing reveals it is not as rock solid as many people believe, with flaws that result in some people wrongly advised to worry about a disease risk and others wrongly told they can relax. Researchers say the study shows the need for consumers to be careful about choosing where to have a gene test done and acting on the results, such as having or forgoing a preventive surgery. More

Dozens of genes in breast cancer tests lack link to risk
Bloomberg
Genetic tests for breast cancer risk often look for DNA flaws that haven't been reliably linked to the disease, a new report found, casting doubt on diagnostics that examine dozens of genes to calculate a patient's susceptibility. Only 11 genes have potential mutations shown to raise the chance of getting breast cancer, according to the article published in the New England Journal of Medicine. More

Stem cells may help bone breaks heal in diabetics
MedPage Today
Treatment with bone marrow-derived stem cells could prove to be an effective strategy for slow healing bone fractures in diabetics, a preclinical study suggested. When nondiabetic human bone marrow-derived mesenchymal stem cells were administered directly to femur fractures in a murine model of diabetes, the bones healed more efficiently than nontreated bone, reported Cynthia Coleman, Ph.D., of the National University of Ireland in Galway and colleagues.More

New findings shed light on complexities of emerging zoonotic malaria
London School of Hygiene & Tropical Medicine via ScienceDaily
Zoonotic malaria has been shown to be caused by two genetically distinct Plasmodium knowlesi parasite subpopulations associated with different monkey host species in Malaysia, according to new research. The authors believe this could have important implications for how the parasite adapts and spreads in humans. More