ASCLS eNewsBytes
Jul. 21, 2015

Stem cells have more reserves for DNA replication
Yale University via Phys.org
In cell division, nothing is as important as the precise replication of billions of genetic letters that make up DNA. Since this genomic integrity is so fundamental to survival, scientists had assumed that replication mechanisms operate the same way in all cells, which depend in part on molecular reserves called dormant origins.More

Bacterial endocarditis increases stroke risk for longer period than previously reported
Health Canal
U.S. researchers have used a controversial cloning technique to make new, healthy, perfectly matched stem cells from the skin of patients with mitochondrial diseases in a first step toward treatment for these incurable, life-threatening conditions. A study on the technique, published in the journal Nature, showcases the latest advance in the use of somatic-cell nuclear transfer to make patient-specific stem cells that could be used to treat genetic diseases.More

Cell division speeds up as part of antibody selection
Rockefeller University via ScienceDaily
In response to an infection, the immune system refines its defensive proteins, called antibodies, to better target an invader. New research has revealed two mechanisms that favor the selection of B cells capable of producing antibodies with the highest affinity for that invader. More

Most people with HIV know status; more testing still needed
Medscape
Five states (Colorado, Connecticut, Delaware, Hawaii and New York) have achieved the National HIV/AIDS Strategy objective of informing at least 90 percent of people with HIV of their status, according to estimates in an article published in the June 26 issue of the Morbidity and Mortality Weekly Report.More

World's largest genetic study in Iceland produced new insights into gene function and disease predisposition that could lead to new clinical laboratory tests
DARK Daily
Over the past 15 years, Iceland has managed to be at the forefront of genetic research tied to personalized medicine and new biomarkers for diagnostics and therapeutics. This is true because, as most pathologists know, Iceland has a small population that has seen little immigration over the past 1,000 years, along with a progressive government and business community. More

Study questions radiation use for 'low-risk' prostate cancers
HealthDay News
Higher doses of radiation may improve survival in men with medium- and high-risk prostate cancers, but it does not do the same for those with low-risk disease, a new study suggests. As is the case with many cancers, doctors must balance the risks and side effects of radiation therapy against its potential benefits when deciding if it's right for a particular patient.More

Parkinson's disease may be treatable with anti-malaria drugs
Medical News Today
There are currently no standard treatments that slow or stop Parkinson's disease — available therapies address each patient's individual symptoms. Now, a breakthrough study successfully identifies two existing anti-malaria drugs that show promise in targeting disease progress.More

2 salmonella outbreaks leave 10 ill, prompting chicken recalls
CNN
The U.S. Centers for Disease Control and Prevention and the U.S. Department of Agriculture Food Safety Inspection Service are working with the Minnesota Department of Health to investigate two separate salmonella outbreaks. A multistate outbreak of salmonella enteritidis has sickened seven people in three states: five in Minnesota, one in Oklahoma and one in Wisconsin. Two of them have been hospitalized.More

FDA makes it easier for Theranos to conduct testing outside of certified labs
MedCity News
Theranos just received Food and Drug Administration clearance that'll allow its newly approved herpes diagnostic to be used outside traditional clinical laboratories. This CLIA waiver is a sign that the storied single-blood-drop test maker will be able accelerate its broader market penetration strategy at a much more rapid clip.More