ASCLS eNewsBytes
Sep. 2, 2014

Researchers identify breast cancer biomarker that could predict outcomes
Fox News
New research has identified a protein as a potential biomarker for breast cancers with poor prognosis. In a study in the October issue of Molecular and Cellular Biology, researchers found that a protein named p66ShcA is highly enriched in breast cancers that have undergone metastasis.More

Top 10 rankings of EHR market share put Epic 1st as hospitals, physicians and clinical laboratories make progress on interoperability
DARK Daily
Across the nation, clinical laboratories and pathology groups are busy interfacing their laboratory information systems to the electronic health record systems of their client hospitals and physicians. Yet, few laboratory managers know which EHR systems are dominating the market and which EHR systems are barely surviving. More

Genomic sequencing reveals mutations, insights into 2014 Ebola outbreak
Broad Institute of MIT and Harvard via ScienceDaily
In response to an ongoing, unprecedented outbreak of Ebola virus disease in West Africa, a team of researchers has rapidly sequenced and analyzed more than 99 Ebola virus genomes. Their findings could have important implications for rapid field diagnostic tests.More

Missing protein associated with early signs of dementia
Medical News Today
Researchers from the University of Warwick in the U.K. claim to have provided the first evidence that the absence of a particular protein — called the MK2/3 protein — is associated with early signs of dementia. They published their findings in the journal Nature Communications.More

Stiff person syndrome treated with stem cell transplantation helps 2 women achieve remission
Medical Daily
Stiff person syndrome is a rare disease of the nervous system that affects fewer than 1 in 1 million people. With so few cases and little information, doctors may be uncertain how to treat this disease. In a paper published by JAMA Neurology, doctors at the University of Ottawa treating two female patients with stiff person syndrome used a previously untried therapy for the disease: autologous hematopoietic stem cell transplantation. More

Study: MERS virus doesn't seem to spread easily
HealthDay News
People infected with the Middle East respiratory syndrome virus are unlikely to pass it to others in their household, a new study suggests. Mostly confined to countries in the Middle East so far, the virus has infected 837 people and killed at least 291, according to the World Health Organization.More

New analysis of old HIV vaccines finds potentially protective immune response
Infection Control Today
Applying the benefit of hindsight, researchers at Duke Medicine have reanalyzed the findings of two historic pediatric HIV vaccine trials with encouraging results. The vaccines had in fact triggered an antibody response — now known to be associated with protection in adults — that was previously unrecognized in the infants studied in the 1990s.More

Gene variants linked to overactive bladder and prolapse in women
medwireNews via News-Medical.Net
A systematic review and meta-analysis of genetic association studies reveals a number of genetic variations associated with overactive bladder and pelvic organ prolapse in women. The U.K. researchers found significant associations between a variation in the gene coding for beta 3 adrenoreceptor and overactive bladder, and a variation in the gene coding for collagen type 3 alpha 1 and prolapse.More

Stem cell breakthrough for 'Cinderella cells'
Medical News Today
The spinal cord, muscle and skeleton cells are all formed from cells called neuromesodermal progenitors. A process of carefully timed chemical signals in the growing embryo instructs NMPs to turn into the different cells required for these body parts. Previously, scientists have been able to grow some types of nerve, muscle and bone cells by converting them from stem cells in the laboratory.More

Researchers identify breast cancer biomarker that could predict outcomes
Fox News
New research has identified a protein as a potential biomarker for breast cancers with poor prognosis. In a study in the October issue of Molecular and Cellular Biology, researchers found that a protein named p66ShcA is highly enriched in breast cancers that have undergone metastasis.More

New insights into the survival and transmission strategy of malaria parasites
Swiss Tropical and Public Health Institute via Infection Control Today
HP1 proteins are found in most eukaryotic organisms and are important regulators of gene silencing. In short, HP1 induces heritable condensation of chromosomal regions. As a result, genes located within these regions are not expressed. Importantly, since this conformation is reversible, HP1-controlled genes can become activated without requiring changes in the underlying DNA sequence.More

CDC raises Ebola outbreak response to highest alert status
HealthDay News
The Centers for Disease Control and Prevention raised the level of its response to the West African Ebola outbreak to its highest alert status. The move allows the agency to expand its role in fighting the growing public health crisis, which gained new urgency as cases of the deadly infection began to be reported in populous Nigeria.More

White House orders US laboratories to take inventory of infectious agents
Reuters
The White House has ordered federally funded laboratories working with infectious agents to conduct an immediate inventory of the pathogens in their laboratories and review their safety and security protocols. The order follows a trio of high-profile mishaps at federal laboratories in recent months, including the mishandling of anthrax and bird flu by researchers at the U.S. Centers for Disease Control and Prevention in Atlanta and the discovery of decades-old samples of smallpox in a U.S. Food and Drug Administration laboratory on the campus of the National Institutes of Health in Bethesda, Maryland.More

How silent genes are activated
HealthCanal
DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation have been documented, involving genome-wide and gene-specific DNA demethylation.More