ASCLS eNewsBytes
Nov. 4, 2014

Miniature human stomach grown from stem cells
Medical News Today
For the first time, scientists have grown a fully functioning, miniature human stomach using pluripotent stem cells. The researchers — from Cincinnati Children's Hospital Medical Center in Ohio — say their creation is an "unprecedented tool" that can be used to study an array of diseases that threaten public health, such as cancer and metabolic syndrome.More

Study confirms obesity-breast cancer link for blacks, Hispanics
HealthDay News
Obesity increases the risk of certain types of breast cancer in postmenopausal black and Hispanic women, two new U.S. studies show. One study of more than 3,200 Hispanic women found being overweight or obese increased the risk for estrogen receptor-negative and progesterone receptor-positive breast tumors among postmenopausal women.More

Immune cells proposed as HIV hideout don't last in primate model
Emory Health Sciences via ScienceDaily
New research sheds light on the question of which cells support viral replication and persistence, and the answers have implications for future efforts to eliminate HIV from the body in human patients.More

Drinking water contaminant, arsenic, implicated in dropping breast cancer rates among some Chileans
Medical Daily
Though arsenic, which found in drinking water, has been linked to harmful effects such as arsenic poisoning, a new study out of the University of California, Berkeley and the Pontifical Catholic University of Chile has found that it might somehow assist in the fight against breast cancer. The results of the study may appear somewhat contradictory to the research that already exists about arsenic's health hazards.More

Researchers create thyroid cells from human stem cells
MedPage Today
Researchers have differentiated human embryonic stem cells into thyroid cells for the first time. By overexpressing two transcription factors — PAX8 and NKX2-1 — Dr. Terry Davies of Mount Sinai Medical Center in New York City and colleagues said they were able to induce stem cells into thyroid cells. More

Improved mouse model will accelerate research on potential Ebola vaccines, treatments
University of North Carolina at Chapel Hill via Infection Control Today
In the war against Ebola, one important hurdle has just been cleared — by a mouse. Researchers at the University of North Carolina at Chapel Hill and colleagues have developed the first genetic strain of mice that can be infected with Ebola and display symptoms similar to those that humans experience. This work, published in the current issue of Science, will significantly improve basic research on Ebola treatments and vaccines, which are desperately needed to curb the worldwide public health and economic toll of the disease.More

Infectious disease outbreaks on the rise, but number of infected people per case falling
Medical Daily
New strains of illnesses and resulting infectious disease outbreaks are on the rise around the globe, Brown University researchers discovered after analyzing data from the last 33 years. Bruised as your eyes feel after reading that, also know there's a general trend whereby each outbreak affects fewer people (the current Ebola crisis excepted).More

Researchers pinpoint exactly where each building block sits in HIV
European Molecular Biology Laboratory via Medical Xpress
Scientists at the European Molecular Biology Laboratory in Heidelberg, Germany, and collaborators from Heidelberg University in the joint Molecular Medicine Partnership Unit have obtained the first structure of the immature form of HIV at a high enough resolution to pinpoint exactly where each building block sits in the virus. The study, published online in Nature, reveals that the building blocks of the immature form of HIV are arranged in a surprising way.More

A matter of life and death: Cell death proteins key to fighting disease
Australian researchers have uncovered key steps involved in programmed cell death, offering new targets for the treatment of diseases including lupus, cancers and neurodegenerative diseases. The research teams from the Walter and Eliza Hall Institute worked together to discover the 3-D structure of a key cell death protein called Bak and reveal the first steps in how it causes cell death. Their studies were published in Molecular Cell and Proceedings of the National Academy of Sciences.More

Narrow networks mean shrinking opportunity for pathology and clinical medical laboratories
DARK Daily
Insurers are increasingly using narrow networks as a business strategy to control costs. As a consequence, more consumers are complaining even as some excluded providers are suing health insurers. For pathologists and clinical laboratory managers, this accelerating trend of excluding providers means increasingly restricted access to patients. More

Single blood test that screens for several cancers steps closer
Medical News Today
Scientists who are working to develop a test that can screen for multiple cancer types from a single blood sample have taken a step closer to their goal. A new study describes how they systematically reviewed thousands of scientific papers and identified hundreds of compounds in the blood of cancer patients.More