ASHI Insights
Oct. 21, 2014

A new Facebook page for Immunoassays from Johns Hopkins
In response to discussions at the 16th International Histocompatibility and Immunogenetics Workshop, members of the Johns Hopkins Immunogenetics Laboratory have created a website for all things related to solid phase antibody immunoassays. At you can enter into discussions about test interpretation and troubleshooting. The site provides information on the latest assays, performance of different test lots, correlations between solid phase and cell based test results, and serum treatments. There is information on bead assays, flow cytometry and ELISA as well as links to relevant publications. Please visit the website and become a member at You can become a site moderator and lead discussions.More

ASHI's 5K Fun Run/Walk
Wednesday, Oct. 22 from 6:30 - 8:00 a.m.

Join us for ASHI's 2nd annual Run for a Life 5K Fun Run/ 1 Mile Walk at the 40th Annual Meeting. Runners and walkers alike will have fun taking in the sights and sounds of Denver as they clear their minds for the days ahead full of educational programming and networking. There is a $25 registration fee and all proceeds from this event will benefit the American Transplant Foundation, so no matter how fast or slow you are, you will be helping to save a life! To register, please stop by the registration booth at the ASHI Annual Meeting!More

ASHI's 40th Anniversary Annual Meeting Social Media Contest!
Starting Friday, October 17th we will be conducting a contest on social media during the annual meeting. Hint: You might want to brush up on your ASHI trivia!

To Win:

Remember to use ASHI’s handle and annual meeting hashtag: *Each like, follow and comment will count as one entry. Daily drawings, winners will be announced on ASHI social media pages and during the morning announcements at the ASHI Annual Meeting. Prizes can be collected at the registration desk. More

1st report on the antibody verification of MICA epitopes recorded in the HLA epitope registry
International Journal of Immunogenetics
The International Registry of HLA Epitopes has been recently established as a tool to understand antibody responses to HLA mismatches. These epitopes are defined structurally by three-dimensional molecular modelling and amino acid sequence differences between HLA antigens. A major goal was to identify HLA epitopes that have been verified experimentally with informative antibodies. This report addresses the identification of MICA epitopes.More

Psoriatic arthritis: HLA genotype tracks with severity
Medscape (free subscription)
Different combinations of variants in the human leukocyte antigen B and HLA-C gene complexes predict, in an additive fashion, sites of inflammation as well as severity of psoriatic arthritis, according to a study published online in the Annals of Rheumatic Disease. Psoriatic arthritis is a phenotypically heterogeneous condition. Muhammad Haroon, M.D., from the Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, and colleagues compared pairwise combinations of alleles that individually are associated with specific clinical characteristics of the disease in 282 patients.More

HLA dosage effect in narcolepsy with cataplexy
Narcolepsy with cataplexy is a sleep disorder caused by the loss of hypocretin-producing neurons in the hypothalamus. It is tightly associated with a specific human leukocyte antigen (HLA)-allele: HLA-DQB1*06:02. Based on this, an autoimmune process has been hypothesized. A functional HLA-DQ molecule consists of a DQα and a DQβ chain. HLA-DQB1*06:02 has a strong preference for binding to HLA-DQA1*01:02, and together they form the functional DQ0602 dimer. More