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Text Version   RSS   Subscribe   Unsubscribe   Archive   Media Kit          June 03, 2014

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Welcome to ASHI Insights, a new service being provided to our members and colleagues in the HLA community! Every two weeks you will receive this news brief featuring Society announcements and a compilation of timely and relevant articles gleaned from the Internet.

It is hoped you will find this to be a convenient and time-saving way to learn about developments in the field without having to do the online searching yourself. While here, please take a moment to click on our supporters’ banner ads and learn about their products and services. It is thanks to them that this publication is possible.

In the future, ASHI will include announcements of general interest in this section. We hope you find ASHI Insights to be a valuable way to keep informed about the Society and the field!


Role of anti-vimentin antibodies in allograft rejection
Human Immunology via ScienceDirect
Production of anti-vimentin antibodies after solid organ transplantation are common. Although classically thought to be expressed mainly within the cytosol, recent evidence demonstrates that extracellular or cell surface expression of vimentin is not unusual. This review examines the evidence to assess whether AVA contribute to allograft pathology. Clinical studies suggest that AVA are associated with cardiac allograft vasculopathy in heart transplant recipients.
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Kidney transplant patients with PKD may have a reduced risk of cancer compared to patients without PKD
Nephrology News & Issues
Patients with polycystic kidney disease may have a reduced risk of cancer compared with patients with other kidney diseases, according to a study appearing in the Journal of the American Society of Nephrology. James B. Wetmore, M.D., M.S., from the University of Kansas Medical Center, and his colleagues conducted the first study to examine cancer risk in kidney transplant recipients with PKD and to compare their risk to that of other kidney transplant recipients.
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Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry
Human Immunology via ScienceDirect
Six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies were calculated using all Be The Match Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation–maximization algorithm in the form of genotype lists generated by interpretation of primary genomic typing data to the IMGT/HLA v3.4.0 allele list. The full cohort consists of 6.59 million subjects categorized at a broad race level.
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ASHI Insights
Colby Horton, Vice President of Publishing, 469.420.2601
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