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ASSOCIATION NEWS

Dr. Marcelo Fernandez-Vina selected to serve on ACBSCT
The Secretary of Health and Human Services invited Dr. Marcelo Fernandez-Vina to serve on the Advisory Council on Blood Stem Cell Transplantation (ACBSCT) of the U.S. Department of Health and Human Services (HHS) starting immediately and ending Oct. 31, 2018. This council advises the Secretary of the HHS and the Administrator of the Health Resources and Services Administration (HRSA) on the activities of the C.W. Bill Young Cell Transplantation Program and the National Cord Blood Inventory (NCBI) Program. ASHI is very grateful that Marcelo has agreed to be our representative on the ACBSCT.
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Fax HLA results to UNOS
Now that kidneys are being shared nationally for high PRA patients, it is even more critical to have access to the extended typing (HLA DPB1, DPA1, DQA1) for deceased organ donors. Any or all of this available information is helpful in evaluating long distance offers for these patients.

DonorNet doesn’t have fields to enter this typing information, but the typing report can be added as an attachment to the donor case. The laboratory that completes the donor’s HLA typing just needs to fax the report to UNOS at 877-366-6768. This fax line is active 24 hours a day/365 days a year to add documents as attachments to donor cases. Please indicate “HLA” and the donor’s UNOS number on the fax cover sheet.

Labs and their coordinators evaluating offers for high PRA patients check the donor attachments for donor DP/DQA. The “Attachments” tab is visible at the top of the main donor page in DonorNet. Some labs have access to DonorNet and can scan the typing directly into the donor attachments. However, we are suggesting the fax method as all labs can utilize it whether or not they have access to DonorNet.

ASHI encourages you to make this a practice until the DonorNet software is updated to allow the reporting of these loci.

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Save the date for the 2015 ASHI Regional Workshops!

Workshop 1: San Antonio, Texas Thursday, April 30 - Saturday, May 2 Marriott Plaza San Antonio

555 S. Alamo Street
San Antonio, Texas 78205
Phone: (210) 229-1000
ASHI Discounted Room Rate: $159+tax*
Online reservations coming soon.

Workshop 2: Philadelphia, Pennsylvania — Thursday, June 18 - Saturday, June 20

Sheraton Philadelphia Downtown Hotel
201 N. 17th St.
Philadelphia, Pennsylvania 19103
Phone: (215) 448-2000

ASHI Discounted Room Rate: $149+tax*
Online reservations coming soon.
Reservation Deadline: May 28

Look for the National Faculty announcement in the next ASHI Insights!

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ASHI University
We are pleased to announce the brand new ASHI University — wait until you see the information available at your fingertips! ASHI U. is a great way to earn Continuing Education Credits online by reading the content in the modules and taking the quizzes. ASHI members have free access to modules and quizzes!

Not a Member? Join today!

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Now is the time to renew your 2015 ASHI Membership online
Doing so today will help to avoid interruption accessing the ASHI Quarterly & ASHI-U for continuing education credits. Your Human Immunology subscription can also be renewed at this time.

Renew now.

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2015 ASHI Proficiency Testing Program



2015 Brochures are available for online ordering.

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Corporate Support
By becoming an ASHI Corporate Supporter, your organization will be contributing to ASHI's educational programs. This is your chance to increase exposure to leading professionals, ASHI members and non-members from all types of organizations and institutions, and the histocompatibility and immunogenetics community worldwide. ASHI offers a variety of support levels to fit your organization's interest, budget and marketing goals. We can help you identify the sponsorship level that best fits your needs and makes the most of your support contributions!

Questions? Please contact ASHI Headquarters at info@ashi-hla.org or 856-638-0428.

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INDUSTRY NEWS


Role of anti-vimentin antibodies in allograft rejection
Human Immunology
Production of anti-vimentin antibodies (AVA) after solid organ transplantation are common. Although classically thought to be expressed mainly within the cytosol, recent evidence demonstrates that extracellular or cell surface expression of vimentin is not unusual. This review examines the evidence to assess whether AVA contribute to allograft pathology.
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TLR7 induces anergy in human CD4+ T cells
Nature Immunology
The recognition of microbial patterns by Toll-like receptors (TLRs) is critical for activation of the innate immune system. Although TLRs are expressed by human CD4+ T cells, their function is not well understood. In this study scientists found that engagement of TLR7 in CD4+ T cells induced intracellular calcium flux with activation of an anergic gene-expression program dependent on the transcription factor NFATc2, as well as unresponsiveness of T cells.
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Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2 and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires
Immunogenetics
Celiac disease is caused by intolerance to cereal gluten proteins, and HLA-DQ molecules are involved in the disease pathogenesis by presentation of gluten peptides to CD4+ T cells. The α- or β-chain sharing HLA molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for the disease. It was recently demonstrated that T cells of DQ2.5 and DQ2.2 patients recognize distinct sets of gluten epitopes, suggesting that these two DQ2 variants select different peptides for display.
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ASHI Insights
Colby Horton, Vice President of Publishing, 469.420.2601
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Lauren Swan, Content Editor, 202.684.7496  
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