ASTS NewsBrief
Mar. 23, 2015

Injured kidneys may be more viable for transplant than previously thought
Medical News Today
A new study led by Yale University in New Haven, Connecticut, overturns previous thinking that injured kidneys from deceased donors are not fit for transplant. The study suggests that such kidneys may be more viable for transplant than is commonly assumed, and as there is a growing demand for organ transplants, they should be considered for use. More

Get the member rate for ATC!
Have you paid your ASTS dues? To receive the member rate for ATC, you must be a member in good standing by April 1. Allowing your membership to lapse also impacts your AJT subscription; delivery to those who have not yet paid membership dues stopped as of March.More

QAPI objective measures webinar April 8
ASTS, AST and representatives from the CMS Survey and Certification Group are pleased to announce a series of webinars on various Quality Assessment and Performance Improvement (QAPI) topics throughout 2015. More

ASTS events at ATC
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Keep in touch!
Have you updated your ASTS member profile lately? If not, please log in to, go to the Member Portal, and click "Your Profile." Your correct mailing address is critical for you to receive the AJT, and we need your current email to keep you up to date on member benefits, news and other valuable ASTS information. More

Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients
American Journal of Transplantation (login required)
In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4 percent), including 13 episodes of disease.More

Geographic inequities in liver allograft supply and demand: Does it affect patient outcomes?
Transplantation (login required)
Researchers analyzed the effect of geographic inequities on patient outcomes. During their study period, 11,244 adult candidates were listed for liver transplantation. A total of 5,285 adult liver allografts became available, and 5,471 adult recipients underwent transplantation. The researchers obtained population data from the 2010 United States Census. To determine the effect of regional supply and demand disparities on patient outcomes, they performed linear regression and multivariate Cox regression analyses. More

Live donor liver transplantation: A valid alternative for critically ill patients suffering from acute liver failure
American Journal of Transplantation (login required)
We report the outcome of live donor liver transplantation (LDLT) for patients suffering from acute liver failure (ALF). From 2006 to 2013, all patients with ALF who received a LDLT (n = 7) at our institution were compared to all ALF patients receiving a deceased donor liver transplantation (DDLT = 26).More

Epidemiology of infections after solid organ and hematopoietic stem cell transplantation
Infectious Disease Special Edition
Infections are common complications of transplantation. The risk for infection is determined by the epidemiologic exposures of the donor and the recipient, as well as the net state of immunosuppression. In general, infections often follow a temporal pattern after solid organ transplantation and hematopoietic stem cell transplantation. However, this timeline has evolved in response to changes in prevention strategies. For example, the onset of cytomegalovirus (CMV) infection, which typically occurs during the first three months after SOT and HSCT, may be delayed by antiviral prophylaxis. More

Liver sharing and organ procurement organization performance
Liver Transplantation (login required)
Whether the liver allocation system shifts organs from better performing organ procurement organizations (OPOs) to poorer performing OPOs has been debated for many years. Models of OPO performance from the Scientific Registry of Transplant Recipients make it possible to study this question in a data-driven manner. More

Independent risk factors for early urologic complications after kidney transplantation
Clinical Transplantation (login required)
Urologic complications are the most frequent technical adverse events following kidney transplantation (KTX). We evaluated traditional and novel potential risk factors for urologic complications following KTX. Consecutive KTX recipients between December 1, 2006 and December 31, 2010 with at least six-month follow-up (n = 635) were evaluated for overall urologic complications accounting for donor, recipient, and transplant characteristics using univariate and multivariate logistic regression. More

Study uncovers predictors of chronic kidney disease worsening in children and adolescents
Medical Xpress
Study results published today in the National Kidney Foundation's American Journal of Kidney Diseases provide new insights into why a child's chronic kidney disease (CKD) may worsen to kidney failure. Among nearly 500 children and adolescents with mild to moderate CKD, researchers identified factors, such as high blood pressure, protein loss from the kidneys, and anemia, that predicted disease worsening but that could be treated to ideally change the course of the disease. More

Machine keeps lungs 'alive' outside the body
USA Today
The medical marvel that saved Kyle Clark's life is about as fantastical as any story the comic books superfan could conceive. A new machine offered at the University of Michigan keeps donor lungs "alive" outside the human body for up to six hours. That gives doctors critical extra time to inspect the lungs as the machine pumps special fluid through them, essentially "reconditioning" them for transplant, said Dr. Paul Lange, the medical director for Gift of Life Michigan. He calls it a "game changer" that will preserve lungs that might otherwise get thrown away as unusable.More