ASTS NewsBrief
Apr. 22, 2013

Rat kidneys made in lab point to aid for humans
The New York Times
Researchers at Massachusetts General Hospital in Boston have made functioning rat kidneys in the laboratory, a bioengineering achievement that may one day lead to the ability to create replacement organs for people with kidney disease. The kidneys were made by stripping donor kidneys of their cells and putting new cells that regenerate tissue into them.More

Chimera Spring Issue Available
The Spring 2013 issue of Chimera magazine is available at Check out the highlights from the 13th Annual State of the Art Winter Symposium and the winter meeting of the ASTS Council, among many other things! And be sure to take a look at our newest feature, Photo Finish, where members can share interesting or unique photos related to transplant surgery.More

ARTS Meeting in Seattle
Pfizer's ARTS (Advancing Research in Transplantation Science) Research Update meeting will be held in Seattle on Saturday, May 18, 7:30 - 9:30 p.m. in the Issaquah Room of the Sheraton Hotel. Presentations of the 9 ARTS research projects on mTOR inhibition will be given by the investigators combined with round table discussions. The meeting is open to the public on a first-come, first-served basis to accommodate the room's maximum capacity.More

Celebrate Donate Life Month
Many hospitals will celebrate National Donate Life Month in April — more than 700 of them as partners in the Workplace for Life Let Life Bloom Hospital Campaign. The WPFL Hospital Campaign web page provides resources including a downloadable Challenge Scorecard, which provides a long list of ways hospitals can promote registration and earn recognition from the Health Resources and Services Administration (HRSA). Most importantly, it's not too late to sign up to be a partner in the WPFL Hospital Campaign. Enroll now.More

Innate immunity in donor procurement
Current Opinion in Organ Transplantation
Ischemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischemia. This review discusses the components of innate immunity known to be involved in renal ischemic reperfusion injury (IRI). Understanding how inflammatory damage is initiated in renal IRI is important for the development of targeted therapies aimed at preserving the donor organ.More

The need to reduce cold ischemia time in kidney transplantation
Current Opinion in Organ Transplantation (subscription required)
Hypothermic preservation is a prerequisite for kidney exchange in transplantation. The severity of tissue damage caused by hypothermic preservation influences the level of ischemia/reperfusion injury and subsequent graft function. With the purpose of reviewing the implications of prolonged cold ischemia time (CIT) in kidney transplantation, its pathophysiology, effects on early and late outcome of transplantation for different types of deceased organ donors, and preservation methods are discussed based on recent literature.More

Vascularized composite tissue allotransplantation — state of the art
Clinical Transplantation (login required)
Vascularized composite tissue allotransplantation is a viable treatment option for injuries and defects that involve multiple layers of functional tissue. In the past 15 years, more than 150 vascularized composite allotransplantation (VCA) surgeries have been reported for various anatomic locations including — but not limited to — trachea, larynx, abdominal wall, face and upper and lower extremities. VCA can achieve a level of esthetic and functional restoration that is currently unattainable using conventional reconstructive techniques.More

Relationship between occurrence of surgical complications and hospital finances
In this hospital system, the occurrence of postsurgical complications was associated with a higher per-encounter hospital contribution margin for patients covered by Medicare and private insurance but a lower one for patients covered by Medicaid and who self-paid. Depending on payer mix, many hospitals have the potential for adverse near-term financial consequences for decreasing postsurgical complications.More

Transmission of Strongyloides stercoralis through transplantation of solid organs
Centers for Disease Control and Prevention
Strongyloides stercoralis is an intestinal nematode endemic in the tropics and subtropics. Immunocompetent hosts typically are asymptomatic, despite chronic Strongyloides infection. In contrast, immunocompromised patients are at risk for hyperinfection syndrome and disseminated disease, with a fatality rate more than 50 percent. The infection source for immunocompromised patients, such as solid organ transplant recipients, is not always apparent and might result from reactivation of chronic infection after initiation of immunosuppressive therapy or transmission from the donor.More

Outcomes and predictive factors of pediatric kidney transplants: An analysis of the Thai Transplant Registry
Pediatric Transplantation (login required)
As universal coverage for pediatric kidney transplantation (KT) was introduced in Thailand in 2008, the number of recipients has been increasing. Researchers evaluated predictive factors for graft failure to understand how to improve clinical outcomes in these children. Using data obtained from the National Transplant registry, they assessed the risk of graft failure using the Kaplan–Meier method and Cox proportional hazards regression.More

Woman pregnant after uterus transplant
ABC News
The first woman to receive a uterus from a dead donor is now pregnant, her doctors announced in Turkey. Doctors waited 18 months after Derya Sert's uterus transplant in August 2011 before they implanted an embryo on April 1 using Sert's own egg. Sert, a 22-year-old homemaker, is now about two weeks pregnant, her doctors at Akdeniz University Hospital in Antalya announced recently.More