ASTS NewsBrief
Aug. 27, 2012

Molecular and protein markers discovered for liver transplant failure from hepatitis C
Medical News Today
Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage. Such early detection of susceptibility to hepatitis C virus-induced liver injury could lead to more personalized monitoring and treatment options after a transplant.More

Chimera summer issue available
ASTS
The Summer 2012 issue of Chimera magazine is now available! Check out the new member-focused feature, "People and Places," which will keep you up to date on your peers' career moves. Also, "Across the Field" returns to spotlight ASTS members and their transplant programs, and you'll find highlights from the 2012 American Transplant Congress and all the latest legislative, regulatory, and reimbursement news. More

ASTS Recognition Awards submissions open
ASTS
Submissions are now open for ASTS Recognition Awards. Recognize a faculty member, mentor, or peer who demonstrates outstanding leadership, stewardship, and capacity to train transplant professionals by nominating them for the Francis Moore Excellence in Mentorship in the Field of Transplantation Surgery Award, the Vanguard Prize, or the Advanced Transplant Provider Award. The deadline for nominations is Friday, Sept. 7, 2012.More

"Increasing Impact of Mitigating Factors on Transplant Programs" webinar Aug. 29
ASTS
This Transplant Communications Inc. webinar will cover how to escape getting caught in the "regulatory purgatory" of being unable to meet new certification requirements CMS is implementing; how to develop a Systems Improvement Agreement with CMS; and what steps one major transplant program has already taken to improve survival outcomes. It will be held Wednesday, Aug. 29, 2012, from 2-3:30 p.m. EST. More

CMV prophylaxis better for preventing graft loss
Renal & Urology News
Prevention of cytomegalovirus disease can be achieved either with prophylactic or preemptive use of antiviral agents after kidney transplantation, but prophylaxis is associated with a lower rate of graft loss or death, according to findings presented at the 24th International Congress of The Transplantation Society. The findings emerged from an ongoing study in which 146 renal transplant recipients were randomized to receive valganciclovir prophylaxis and 150 were randomized to receive preemptive therapy with the drug.More

Aggressive lung donor management increases graft procurement without increasing renal graft loss after transplantation
Clinical Transplantation (subscription required)
To determine the impact of an aggressive protocol on the rate of lung grafts available for transplant, researchers analyzed the impact of aggressive management on kidney graft survival after kidney transplantation. Aggressive management strategy in potential lung donors, which includes ventilator recruitment maneuvers, PEEP ≥8 cm H2O, the use of HRT and restrictive fluid balance increases the rate of lung grafts available for transplantation without adverse effect on kidney graft survival.More

Donor information for living donor liver transplantation: Where can comprehensive information be found?
Liver Transplantation (subscription required)
Recently published data show that a large number of candidates for living donor liver transplantation (LDLT) actively look for additional information on the Internet because today it represents the main source of information for many of them. However, little is known about the quality of the information on LDLT available on the Internet. Analysis demonstrated several significant shortcomings in the quality of the information provided to potential donors for LDLT according to the EQIP instrument. Researchers conclude that there is an urgent need to produce a website compliant with international standards for the quality of donor information.More

Health organizations form solid organ transplant program
Milwaukee Journal Sentinel
Four major health institutions in the Milwaukee area have pooled resources to form a new solid organ transplant program and have recruited a nationally known expert in liver transplantation to lead the new partnership. The collaboration, which involves Children's Hospital of Wisconsin, Froedtert Hospital, Medical College of Wisconsin and BloodCenter of Wisconsin, is geared toward bringing together specialists and creating one of the leading transplant centers in the country. Gil White, executive vice president for research at the BloodCenter of Wisconsin, said the arrangement will allow the center's immune system research group to coordinate its work with similar research groups at the other institutions.More

Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation
Current Opinion in Organ Transplantation (subscription required)
As critical determinants of the local and systemic immune response to solid organ allografts, macrophage subpopulations represent attractive therapeutic targets. Rapid progress is being made in the implementation of novel macrophage-targeted therapies, particularly in the use of ex-vivo-generated M regs as a cell-based medicinal product.More

New West Nile threat: kidney disease
WebMD
Early in this year's West Nile virus season, the death toll is at 29 and rising. There have been about 700 illnesses reported so far, more than 400 of them serious meningitis or encephalitis. It's an unusually severe West Nile season — and now there's new evidence that the virus itself may be unusually dangerous. The new threat: kidney disease years after infection.More

CDC to Baby Boomers: Get tested for hepatitis C
The Associated Press via ABC News
All baby boomers should get a one-time blood test to learn if they have the liver-destroying hepatitis C virus, U.S. health officials said. It can take decades for the blood-borne virus to cause liver damage and symptoms to emerge, so many people don't know they're harboring it. Baby boomers account for about two-thirds of the estimated 3.2 million infected Americans.More

Kidney transplant: Blood condition raises kids' risk
Futurity
For children receiving kidney transplants, a potentially correctable blood condition is associated with a moderately increased risk of the graft's later failure. Findings suggest clinicians should weigh whether transplant is advisable when the condition is present, according to findings presented by researchers at the University of California, Davis, at the 24th International Congress of the Transplantation Society in Berlin.More