ASTS NewsBrief
Sep. 7, 2015

Risk factors for type 1 diabetes recurrence in immunosuppressed recipients of simultaneous pancreas-kidney transplants
American Journal of Transplantation (login required)
Patients with type 1 diabetes (T1D) who are recipients of pancreas transplants are believed to rarely develop T1D recurrence in the allograft if effectively immunosuppressed. We evaluated a cohort of 223 recipients of simultaneous pancreas–kidney allografts for T1D recurrence and its risk factors. With long-term follow-up, recurrence was observed in approximately 7 percent of patients. Comparing the therapeutic regimens employed in this cohort over time, lack of induction therapy was associated with recurrence, but this occurs even with the current regimen, which includes induction; there was no influence of maintenance regimens. Longitudinal testing for T1D-associated autoantibodies identified autoantibody positivity, number of autoantibodies, and autoantibody conversion after transplantation as critical risk factors. More

ASTS recognition award nominations open
ASTS
Has a faculty member, mentor, or peer had a positive influence on your career? Say thank you by nominating them for an ASTS Recognition Award! More

Spots still available for ASTS Leadership Development Program
ASTS
There’s still time to register for the 2015 Leadership Development Program September 27-30. This course is the only one of its kind, combining specific case studies and expertise in transplantation with experts in leadership and organizational topics from Northwestern's Kellogg School of Management. More

Registration open for ASTS 2016 Winter Symposium
ASTS
As more patients suffer due to the shortage of life-saving donor organs each year, ASTS is focusing its Winter Symposium on innovative science and effective public policy to combat this crisis. Register today to join us in Miami Jan. 14-17, 2016, to learn what is being done to save lives through expanding organ transplantation—and how you can help.More

Rates of kidney transplantation from living and deceased donors for blacks and whites in the United States, 1998 to 2011
JAMA Internal Medicine
This database review found that by 2010 the incidence of kidney transplantation for black and white patients with end-stage renal disease was equivalent, but kidney transplants from living donors were 43.2 percent for whites and only 22.2 percent for blacks. Kidney transplantation, the treatment standard for patients with end-stage renal disease (ESRD), is associated with prolonged survival, improved quality of life, reduced morbidity, and lower health care costs compared with dialysis.More

A multicenter study of 30 days complications after deceased donor liver transplantation in the model for end-stage liver disease score era
Liver Transplantation (login required)
Knowledge of risk factors for posttransplant complications is likely to improve patient outcomes. Few large studies of all early postoperative complications after deceased donor liver transplantation (DDLT) exist. Therefore, researchers conducted a retrospective, cohort study of 30-day complications, their risk factors and the impact on outcomes after DDLT.More

Where the sun shines: Industry's payments to transplant surgeons
American Journal of Transplantation (login required)
The Open Payments Program (OPP) was recently implemented to publicly disclose industry payments to physicians, with the goal of enabling patient awareness of potential conflicts of interests. Awareness of OPP, its data, and its implications for transplantation are critical. We used the first wave of OPP data to describe industry payments made to transplant surgeons. Transplant surgeons (N = 297) received a total of $759 654. More

Telaprevir- and boceprevir-based triple therapy for hepatitis C in liver transplant recipients with advanced recurrent disease: A multicenter study
Transplantation (login required)
Antiviral treatment with sustained virologic response improves survival in liver transplant recipients and is especially relevant to patients with advanced recurrent hepatitis C virus. Researchers assessed the safety and efficacy of protease inhibitor–based triple therapy in patients with recurrent advanced fibrosis and cholestatic hepatitis.More

Hyponatremia, hypo-osmolality, and seizures in children early post-kidney transplant
Pediatric Transplantation (login required)
Post-transplant seizures are uncommon in young kidney transplant recipients but can be harbingers of devastating outcomes such as cerebral edema and death. We reviewed all transplants performed at our institution from January 2013 to January 2014 and compared three patients who seized within 24 h post-transplant (cases) with the remaining 33 transplant recipients (controls). Records were reviewed for hyponatremia, hypocalcemia, hypomagnesemia, BUN clearance, osmolality shifts, and blood pressure control in the first 24 h post-transplant.More

New sensor predicts which lung transplants will fail
IEEE Spectrum
With a tiny chip-based sensor and 30 minutes of time, surgeons could evaluate a lung destined for transplantation and predict whether that donated organ is likely to fail or whether it will save a life. In lung transplant surgery, the clock is ticking. Once surgeons remove the donor lung they have about 7 hours before it's too damaged to be used, and transplant teams often rush the organ via helicopter to the hospital where a desperate recipient is waiting. More