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Ribavirin may treat hepatitis E infection in transplant recipients
Renal & Urology News
Ribavirin may be an effective form of monotherapy for solid-organ transplant patients with chronic hepatitis E virus (HEV) infection, French researchers reported in a study published online ahead of print in The New England Journal of Medicine.
"To date, there is no established therapy for HEV infection," a research team led by Dr. Nassim Kamar, Ph.D., of Toulouse University, stated. "Here we report a combined case series from several transplantation centers in France, involving solid-organ transplant recipients infected with HEV who were treated with ribavirin alone."
ASTS Officer and Councilor voting open
All eligible ASTS voting members were sent a link to vote via a secure online system on April 1. If you are eligible to vote and did not receive the email, please contact firstname.lastname@example.org. Election results will be formally announced at the annual ASTS business meeting at WTC in July.
RAPID software available free to ASTS members
RAPID (Real-time Analysis and Process Improvement Dashboard) is open source software that provides outcomes and quality dashboards to monitor your center's SRTR Program Specific Reports (PSR) performance. Originally developed at Northwestern Medicine Comprehensive Transplant Center, it is being distributed through ASTS at no charge to its members.
UNOS names new executives
Stephen Harms has been selected as Chief Operating Officer of UNOS, and Alex Tulchinsky has been selected as UNOS' Chief Technology Officer. Harms will oversee key projects that promote UNOS' strategic plan, while Tulchinsky will oversee development and maintenance of the technology platforms that match donated organs with patients nationwide; collect key clinical information on organ donors and transplant candidates and recipients; and facilitate communication of real-time information and data needed to facilitate medical decision-making.
XynManagement provides an integrated solution for transplant centers to identify SRTR risk, track outcomes and improve performance. XynManagement’s HIPPA-compliant, cloud-based software platform improves data capture, ensuring your data reflect the true risk of transplants performed. Using simple, effective graphics, the system predicts risk at the individual patient level and assesses program-wide risk on future SRTR reports.
Medicare rules make offsite organ recovery costly
Using organ procurement organizations reduces costs and is safer for patients and medical staff. But complex reimbursement rules deter some transplant hospitals from allowing organs from brain-dead donors to be recovered off site.
Bland embolization versus chemoembolization of hepatocellular carcinoma before transplantation
Liver Transplantation (login required)
There is conflicting literature regarding the superiority of transarterial chemoembolization (TACE) versus bland transarterial embolization (TAE), and this has not been well studied before transplantation. Twenty-five TAE patients were matched in a 1:2 ratio with TACE patients by the initial radiographic tumor size and number in a retrospective, case-controlled study.
Medical outcomes of adolescent live kidney donors
Pediatric Transplantation (login required)
Living kidney donation from donors less than 18 years of age is uncommon. The majority of donations from adolescents took place several decades ago providing a unique opportunity to study true long-term consequences of donation. In this study, authors compared survival, renal outcomes and rates of hypertension and diabetes among 42 adolescent donors and matched older controls
Post-transplant hip fracture rate declining
Renal & Urology News
Hip fractures remain an important complication following kidney transplantation, but the incidence of these fractures has decreased substantially since 1997, according to a new study.
The study, led by Dr. Wolfgang C. Winkelmayer, ScD, associate professor of medicine and director of clinical research in the Division of Nephrology at Stanford University of School of Medicine in Palo Alto, Calif., included 69,740 patients who under kidney transplantation from 1997 to 2010.
Transplantation genetics: current status and prospects
American Journal of Transplantation
Over the last decade, advances in genetic technologies have accelerated our understanding of the genetic diversity across individuals and populations. Case–control and population-based studies have led to several thousand genetic associations across a range of phenotypes and traits being unveiled. Despite widespread and successful use of organ transplantation as a curative therapy for organ failure, genetic research has yet to make a major impact on transplantation practice aside from HLA matching. New studies indicate that non-HLA loci, termed minor histocompatibility antigens (mHAs), may play an important role in graft rejection.
Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors
American Journal of Transplantation (login required)
Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative, but existing regimens rely on steroids and have higher rejection rates. Experimentally, donor bone marrow and sirolimus promote belatacept's efficacy. To investigate a belatacept-based regimen without CNIs or steroids, authors transplanted recipients of live donor kidneys using alemtuzumab induction, monthly belatacept and daily sirolimus.
Polyomavirus BK viremia in kidney transplant recipients after desensitization with IVIG and rituximab
Transplantation (login required)
Desensitization with intravenous immune globulin (IVIG) and rituximab improves transplantation rates. It is unclear if desensitization increases the risk of polyomavirus BK (BKV) viremia. Here, BKV viremia in HLA-sensitized patients after desensitization with IVIG and rituximab was analyzed.
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