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Fewer kids die while waiting for new organs
Fewer children died waiting for organ transplants in the past decade after policy changes to the national organ allocation system, researchers stated.
The number of children dying before they could receive a transplant dramatically decreased from 262 to 110 as pediatric transplants increased from 2001 to 2010, stated Jennifer Workman, MD, of the University of Utah School of Medicine in Salt Lake City and colleagues, in Pediatrics.
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2013 ASTS Transplant Surgeon Compensation Survey available
The 2013 ASTS Transplant Surgeon Compensation Survey Report is now available for purchase in the ASTS store (please log in for member pricing). The report is designed to allow individuals to easily compare their salary and benefits with their peers. Institutions can also use the data to benchmark compensation. A staff level and a leadership level version of the results are available. Data have been aggregated by region, practice type, personal and center volume and primary practice in order to provide the most comprehensive data. Members who participated in the survey received a complimentary copy of the results. Please contact firstname.lastname@example.org with questions about the survey.
Check out the new ASTS.org
All ASTS members were sent an email with their username and new password to access the members-only areas of the new website. If you did not receive it, please click on "Log In" and try the "forgot password" link or contact email@example.com for your login information. We encourage you to change your password in the Member Portal using the "Change Password" link. Stop by and see what the new site has to offer!
ASTS events at ATC
If you are planning to attend the American Transplant Congress in Seattle May 18–22, don't forget these ASTS events:
Presentation of the ASTS research grants at 9:15 a.m. on Tuesday, May 21, in the general session room
ASTS Presidential Address at 9:30 a.m. on Tuesday, May 21, in the general session room
ASTS Business Meeting at 5:45 p.m. Tuesday, May 21 (members only), in Room 2AB
ASTS Member Reception at 7 p.m. in the North Galleria
Post-liver transplant survival rates high among pediatric, adult patients with lethal genetic syndromes
Patients who underwent liver transplantation to treat lethal genetic syndromes experienced high rates of survival, while factors such as age and preoperative life support increased mortality risk, in a recent study. Researchers evaluated data from 78 adults and 74 pediatric patients who underwent orthotopic liver transplantation for lethal genetic syndromes (LGS) between Feb. 1, 1984 and Sept. 9, 2012 at the University of California, Los Angeles. Diagnostic methods and treatment outcomes, including recurrence and graft and patient survival, were compared between groups.
Tripped T-cells reject transplant organs
Certain cells "stick their feet" in the bloodstream to trip-up and collect immune system T-cells, which can lead to transplant organ rejection. This recent discovery challenges a long-held assumption about how biologic pathways trigger immune system rejection of donor organs — and suggests a different paradigm is needed to develop better anti-rejection therapies.
Post-transplant bone preservation strategy not helpful
Renal & Urology News
Vitamin D and calcium supplementation is commonly used to prevent bone loss after kidney transplantation, but new findings presented at the 2013 American Transplant Congress suggest that such supplementation may not work.
Survey: Incidence of death and potentially life-threatening near-miss events in living donor hepatic lobectomy
Liver Transplantation (login required)
The incidence of morbidity and mortality after living donor liver transplantation (LDLT) is not well understood because reporting is not standardized and relies on single-center reports. Aborted hepatectomies (AHs) and potentially life-threatening near-miss events (during which a donor's life may be in danger but after which there are no long-term sequelae) are rarely reported. Researchers recently conducted a worldwide survey of programs performing LDLT to determine the incidence of these events. A survey instrument was sent to 148 programs performing LDLT.
Study: The effect of liver transplantation on fatigue in patients with primary biliary cirrhosis
Journal of Hepatology (login required)
Liver transplantation is associated with improvement in fatigue in patients with primary biliary cirrhosis (PBC). However, a substantial proportion of patients continue to suffer from significant fatigue after two years. Whether the improvement is enough to justify organ allocation in patient with fatigue alone, without liver failure, is still an open issue. Certainly, in the era of organ shortage with many patients dying waiting for a graft, this may not represent the optimal use of donated deceased organs.
Hyperacute rejection in the xenogenic transplanted rat liver is triggered by the complement system only in the presence of leukocytes and free radical species
Xenotransplantation (login required)
Reactive oxygen species (ROS) and nitric oxide species (NOS) are pivotal after ischemia–reperfusion. However, the role of different cells on the formation of free radical species after xenotransplantation remains elusive. It has been hypothesized that ROS and NOS formed during hyperacute rejection are dependent on leukocytes, erythrocytes, activated thrombocytes and Kupffer cells (KCs). To address this issue, researchers developed a model of xenoperfused rat liver and assessed the relationship between free radical production and graft dysfunction.
Fungal infections after liver transplantation: Outcomes and risk factors revisited in the MELD era
Clinical Transplantation (login required)
Antifungal prophylaxis is recommended in high-risk patients, but risk criteria remain unclear and the predictive value of model of end-stage liver disease (MELD) score is unknown. In a retrospective, single-center analysis of 667 liver transplants, potential risk factors for fungal infection were assessed, including MELD score.
Donor criteria consensus sought in Canada
Renal & Urology News
A team is hammering out consensus criteria across Canada for assessment and acceptance of donors involved in the Living Donor Paired Exchange (LDPE) registry run by Canadian Blood Services. An important objective of these criteria is to streamline donor assessment so that donors who live far from recipients do not have to be assessed twice: Once at the center closest to their home and again at the center where the recipient will undergo transplantation. This is a common dilemma in the LDPE, which pairs unrelated donors and recipients across the country.
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