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Graft-versus-host disease after simultaneous pancreas-kidney transplantation
American Journal of Transplantation (login required)
Graft-versus-host disease (GVHD) after solid organ transplantation is rare and usually fatal. We present, to our knowledge, the second successfully treated case in a simultaneous pancreas–kidney (SPK) transplant recipient. A 29-year-old female with end-stage renal disease from type 1 diabetes mellitus received an SPK transplant from a male donor, with rabbit-antithymocyte globulin induction. Twelve days posttransplant, she was readmitted with abdominal pain, nausea and vomiting. She developed leukopenia, abnormal liver enzymes, fever and a skin rash. Skin biopsy showed interface dermatitis consistent with allergic reaction versus GVHD.
Consensus conference on training in HBP surgery
ASTS, along with the American Hepato-Pancreato-Biliary Association and the Society of Surgical Oncology, will hold a consensus conference on Training in HBP Surgery Oct. 27, 2014, at the Omni San Francisco.
Got your ASTS history book?
Have you gotten your copy of the ASTS 40th anniversary book yet? One free copy is available to ASTS members, and non-members can purchase a copy in the ASTS Store.
Help fund the future!
The ASTS Foundation Fund the Future Campaign has a goal of raising $100,000 to fund research grants. We need your help! Please consider donating any amount.
Solid organ transplant donors with central nervous system infection
Transplantation (login required)
While donor-derived infections (DDI) remain uncommon, multiple reports describe DDI with pathogens that cause central nervous system (CNS) infection resulting in significant recipient disease. The Ad Hoc Disease Transmission Advisory Committee (DTAC) reviewed the records of potential donor-derived disease transmission events (PDDTE) to describe donor characteristics and outcomes associated with DDI from CNS pathogens.
Comparative effectiveness of liver transplant strategies for end-stage liver disease patients on renal replacement therapy
Liver Transplantation (login required)
There are complex risk-benefit tradeoffs with different transplantation strategies for end-stage liver disease patients on renal support. Using a Markov discrete-time state transition model, scientists compared survival for this group with three strategies: simultaneous liver-kidney transplantation, liver transplantation alone (LTA) followed by immediate kidney transplantation if renal function did not recover, and LTA followed by placement on the kidney transplant wait list.
Transmission of LDLR mutation from donor through liver transplantation resulting in hypercholesterolemia in the recipient
American Journal of Transplantation (login required)
Donor-transmitted disease in organ transplantation is uncommon, but possible. The LDL receptor, a key regulator of lipoprotein metabolism, is abundant in the liver. Mutations in the LDLR gene, leading to reduced LDLR activity, are the main cause for familial hypercholesterolemia. The estimated prevalence of FH is 1/200–1/500 in the population indicating that there are 14–34 million individuals with FH worldwide. We describe a patient who developed severe hypercholesterolemia after liver transplantation.
Sarcoidosis-associated pulmonary hypertension and lung transplantation for sarcoidosis
Pulmonary hypertension (PH) is a significant complication of sarcoidosis, occurring in 6 to 74 percent of patients. The presence of PH markedly increases mortality among these patients; this effect is independent of pulmonary function. As will be discussed in detail later, lung transplantation (LT) is a viable therapeutic option for severe pulmonary parenchymal or vascular disease refractory to medical therapy in patients with sarcoidosis, but has significant morbidity and mortality.
Should animal organs be farmed for human transplants?
Medical News Today
Recently, Medical News Today reported on a breakthrough in xenotransplantation — the science of transplanting functional organs from one species to another. Scientists from the Cardiothoracic Surgery Research Program of the National Heart, Lung and Blood Institute demonstrated success in keeping genetically engineered piglet hearts alive in the abdomens of baboons for more than a year.
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Uric acid and clinical correlates of endothelial function in kidney transplant recipients
Clinical Transplantation (login required)
Uric acid is associated with increased mortality in kidney transplant recipients, but it is uncertain if this involves endothelial dysfunction. We hypothesized, first, that there was an association between uric acid and endothelial function, and second, that there were associations between endothelial function and cardiac and mortality risk scores.
Study: Age, medications play role in post-transplant cancer rate
By Karen Zabel
Organ transplant recipients regularly receive immunosuppressive drugs to help minimize the risk of rejection, but those drugs come with significant risks of their own, including leaving patients open to predatory infections and even certain types of cancer. Now, a new study suggests the type of immunosuppressant drug used as well as other factors may help predict those risks and possibly reduce them. The study was presented at the 2014 World Transplant Congress in San Francisco.
Many kidney failure patients have concerns about pursuing kidney transplantation
Nephrology News & Issues
Concerns about pursuing kidney transplantation are highly prevalent among kidney failure patients, particularly older adults and women, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology. Dorry Segev, M.D., Ph.D., and his colleagues conducted a study to understand the concerns and perceived barriers that dialysis patients have about pursuing transplantation, and what patient characteristics are associated with such concerns.
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