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Frailty tied to lower survival rates after kidney transplant
HealthDay via U.S. News & World Report
Physical frailty may lead to worse five-year survival rates among kidney transplant patients, regardless of their age, a new study shows.
The findings suggest that patients should be screened for frailty before kidney transplantation, and that those identified as frail need to be closely monitored after their transplant, the study authors said.
The researchers assessed frailty in 537 patients around the time of their kidney transplant. Five years later, survival rates were 91.5 percent for non-frail patients, 86 percent for intermediately frail patients, and 77.5 percent for frail patients, according to the study published online Oct. 30 in the American Journal of Transplantation.
National Living Donor Assistance Center funding renewed
The University of Michigan, in partnership with the American Society of Transplant Surgeons and Arbor Research Collaborative for Health, are pleased to announce they have been selected to continue operating the National Living Donor Assistance Center (NLDAC). Funding for this program was renewed by the Healthcare Systems Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, which will provide up to $3.5 million yearly for up to five years.
Reminder: 2015 ASTS Council nominations due Nov. 12
Nominations are being accepted for councilor-at-large, treasurer, and president-elect positions for terms beginning in May 2015. The deadline is Nov. 12, 2014.
ASTS history in your hands
The ASTS 40th anniversary book is full of pictures and fun facts about the Society, its members, and the field of transplantation. One free copy is available to ASTS members, and non-members can purchase a copy in the ASTS Store.
Whose kidney is it anyway? The complexities of sharing deceased donor kidneys
American Journal of Transplantation
Disparities in Access to Kidney Transplantation Between Donor Services Areas in Texas by Lewis et al is a clarion call for wider geographic sharing of donated kidneys in this country. The arbitrary boundaries of donor service areas are the impediment to equitable access for patients and Texas, although not unique, is a case study in how gerrymandering DSAs to serve individual transplant center agendas results in disenfranchisement of patients.
Australian doctors transplant 'dead' hearts in surgical breakthrough
Australian surgeons said they have used hearts that had stopped beating in successful transplants, in a world first that could change the way organs are donated. Until now, doctors have relied on using the still-beating hearts of donors who have been declared brain dead, often placing the recovered organs on ice and rushing them to their recipients.
Disparities in access to kidney transplantation between donor service areas in Texas
American Journal of Transplantation
We examined the current status of pronounced disparities in waiting times to kidney transplantation within the state of Texas first documented more than a decade ago. The state's three, geographically contiguous donor service areas were compared for rates of deceased donor KTx within 3 years of listing as well as population base; waiting list size; number of dialysis patients; annual eligible deaths; number and size of acute care hospitals; organ procurement organization performance; correspondence between DSA of residence versus DSA of listing; and distribution of alternative local units. The data show that significant inequities of access to KTx are persistent, localized to one of the state's three DSAs and disproportionately affect Hispanics as well as counties with lower median family incomes.
A private jet is waiting to take you to your kidney transplant
The supply and demand imbalance between organs and the people who need them means that wait lists in New York or San Francisco might be twice that of, say, Kansas or Tennessee. The problem was brought to public attention in recent years by Steve Jobs, who used his resources to travel across the country for a liver transplant. For decades, doctors and policymakers have debated how to move organs or change allocation maps in an effort to eliminate these disparities.
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Renal outcomes of simultaneous liver-kidney transplantation compared to liver transplant alone for candidates with renal dysfunction
Clinical Transplantation (purchase required)
It is unclear whether a concomitant kidney transplant grants survival benefit to liver transplant (LT) candidates with renal dysfunction (RD). We retrospectively studied LT candidates without RD (n=714) and LT candidates with RD who underwent either liver transplant alone (RD-LTA; n=103) or simultaneous liver kidney transplant (RD-SLKT; n=68). RD was defined as renal replacement therapy (RRT) requirement or Modification of Diet in Renal Disease (MDRD) glomerular filtration rate (GFR).
Organovo only 4-6 years away from 3-D printing partial livers for human implantation
"There are so many areas within the 3-D printing space one can get excited about; however, in my opinion one of the most exciting areas is the work being done by San Diego-based Organovo, led by CEO Keith Murphy. Although a young company, they are at the forefront of research and development pertaining to the 3-D printing of numerous human tissues," writes Brian Krassenstein.
Metabolic syndrome after pediatric liver transplantation
Liver Transplantation (purchase required)
Half of adult liver transplantation (LT) recipients develop metabolic syndrome, but the prevalence after childhood LT remains unknown. We conducted a national cross-sectional study of all living patients who had undergone LT between 1987 and 2007 at an age less than 18 years. We gathered information on blood pressure, body composition, serum lipids, glucose metabolism, and histological liver fat content.
World's smallest liver-kidney transplant saves toddler's life
By Lynn Hetzler
Aspen Erickson was only 2 months old when doctors diagnosed her with alpha-1 antitrypsin deficiency. Her parents watched helplessly as their little girl experienced seizures and weight loss. To have a chance at a normal life, Erickson would need a combined liver-kidney transplant. At 16 months old, Erickson received her transplant in a six-hour procedure at University of Utah Health Care. At the time of the procedure, the physicians did not realize Erickson would be the youngest person ever to undergo the procedure.
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