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ASTS applauds House passage of HOPE Act
The American Society of Transplant Surgeons (ASTS) applauds the passage of the HIV Organ Policy Equity (HOPE) Act (S. 330/H.R. 698) by the U.S. House of Representatives on Nov. 12. The bill, which passed the Senate in June, now goes to President Obama for his signature.
ASTS Council Nominations close Dec. 2
The ASTS Nominating Committee is accepting nominations for the following positions on the ASTS Council for terms beginning in July 2014: president-elect, secretary, and 3 councilor-at-large positions. Nominations will be accepted until Dec. 2, 2013.
Help ASTS celebrate!
A highlight of the Winter Symposium will be the 40th Anniversary Gala, and you can help ASTS celebrate by sending any photos you may have that reflect on the history of the Society. Please look through your old (or not so old) photos and send the ones that catch your eye to firstname.lastname@example.org. Don't worry if you only have prints — just mail them to the ASTS National Office, Attn: Diane Mossholder, 2461 S. Clark St., Suite 640, Arlington, VA 22202, and we will return them to you!
Diabetes hikes infection-related death risk post-transplant
Renal & Urology News
Diabetes mellitus is an independent risk factor for infection-related death after kidney transplantation, data presented at the American Society of Nephrology's Kidney Week 2013 meeting show.
Manvir Kaur Hayer, MBChB, and collaborators at the Renal Institute of Birmingham, Queen Elizabeth Hospital, Birmingham, U.K., analyzed data from 19,103 kidney transplant recipients, of whom 2,968 had diabetes mellitus at the time of transplantation. Following transplantation, 2,085 patients died; 433 of the deaths were due to infection. The risk for death from any cause after transplantation was significantly higher for diabetics than non-diabetics, as was the risk for infection-related death.
Transplantation results of completely HLA-mismatched living and completely HLA-matched deceased-donor kidneys are comparable
Transplantation (login required)
Human leukocyte antigen (HLA) mismatches are known to influence graft survival in deceased-donor kidney transplantation. We studied the effect of HLA mismatches in a population of recipients of deceased-donor or living-donor kidney transplantations.
Study: Vitamin D deficiency and mortality in patients receiving dialysis
Journal of Renal Nutrition (login required)
Although several studies have shown poorer survival among individuals with 25-hydroxy (OH) vitamin D deficiency, data on patients receiving dialysis are limited. Using data from the Comprehensive Dialysis Study (CDS), researchers tested the hypothesis that patients new to dialysis with low serum concentrations of 25-OH vitamin D would experience higher mortality and hospitalizations.
Donor risk prediction: how 'extended' is safe?
Current Opinion in Organ Transplantation (login required)
This article reviews recent developments in the selection of the lung donor that aim to increase donor organ use. The scarcity of suitable donor organs continues to limit lung transplantation resulting in long waiting times and significant mortality for those patients awaiting transplantation.
New HCV drugs offer hope after transplant
The advent of new all-oral regimens for hepatitis C (HCV) offers hope to patients who have undergone liver transplant and had the disease recur, a researcher said here.
Patients with hepatitis C who get a new liver universally have a recurrence of the disease in the new organ, according to Dr. Michael Charlton of the Mayo Clinic in Rochester.
Peritransplant lymphopenia Is a novel prognostic factor in recurrence of hepatocellular carcinoma after liver transplantation
Transplantation (login required)
Absolute lymphocyte count (ALC) is considered a surrogate marker for the level of immunosuppression and nutritional status of patients and a prognostic factor for survival and recurrence in several cancers. The aim of this study was to investigate the prognostic value of peritransplant ALC for the recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT).
Many liver transplant patients unable to afford meds
Medscape (login required)
One in 6 liver transplant recipients say they make trade-offs between buying food and their medication or they space out doses because they cannot afford them and try to make them last longer, a new study finds.
"Transplantations are not immune from these cost barriers," Marina Serper, MD, a transplant hepatology fellow at the University of Pennsylvania in Philadelphia, told Medscape Medical News. "Financial situations change. These things are important in the chronic disease population, and they're important in the transplant population as well."
Predictors of cancer risk in the long-term solid-organ transplant recipient
Malignancy is increasingly the leading cause of mortality in solid-organ recipients. Cancer incidence among the transplant population is overall threefold to fivefold higher than the general population with poorer outcomes for late-stage disease. Insights into the identification of patients at particular risk of developing a posttransplantation malignancy are imperative to ensure appropriate measures are instigated to reduce associated morbidity and mortality. This review focuses on potential clinical, immunologic and genetic translational markers aimed at identifying long-term solid-organ transplant patients at high risk of developing cancer.
Surge of liver cancer patients on transplant waitlists
Patients with hepatocellular carcinoma account for an increasing proportion of patients infected with hepatitis C on the waiting list for liver transplantation, a retrospective cohort study has found.
"We feel that primary prevention for hepatocellular carcinoma will be key to reversing this trend," Jennifer Flemming, MD, from Queen's University in Kingston, Ontario, told Medscape Medical News.
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