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The new OPTN kidney allocation policy: Potential for inequitable access among highly sensitized patients
American Journal of Transplantation
In 2013, the Organ Procurement and Transplantation Network approved a new national kidney allocation scheme (KAS) for deceased donor (DD) transplantation. Among the many attributes of the new policy was the decision to proactively address organ allocation to highly sensitized patients, long recognized to be the most disadvantaged group on the waiting list. Beginning on Dec. 4, 2014, the new KAS will be implemented and candidates with calculated panel reactive antibody (cPRA) values of 98 percent, 99 percent and 100 percent will have the highest priority for local, regional and national sharing, respectively. This approach is projected to improve the access of patients in this group to compatible organs.
Giving Tuesday is tomorrow!
Giving Tuesday is the day set aside for charitable giving after Black Friday, Small Business Saturday, and Cyber Monday. ASTS is excited to announce that the first $5,000 in donations to the ASTS Foundation will be matched on Dec. 2, Giving Tuesday! Please plan to participate and make your support for the Society count twice.
WTC OnDemand free to ASTS members
WTC OnDemand is your online portal to educational information from a variety of sessions from the World Transplant Congress. This portal allows you to view Congress sessions virtually, and access is free to ASTS members!
ASTS Research Grants open
Submissions for the 2015 ASTS Research Grants are being accepted until January 9, 2015, at 3 p.m. Eastern.
Central nervous system complications after liver transplantation: Common but mostly transient phenomena
While central nervous system complications (CNSc) are common after liver transplantation (OLT), standardized prospective studies are still lacking. This prospective study aims to determine the incidence of CNSc, to describe clinical presentations and to establish predicting factors of CNSc. One-hundred-thirty-six adult patients who underwent OLT at Hannover Medical School between December 2008 and June 2011 were included.
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Liver, pancreas and kidney transplantation for the treatment of Wolcott-Rallison syndrome
American Journal of Transplantation
We present the case of a child who underwent a combined liver, pancreas and double kidney transplant following complications of Wolcott–Rallison syndrome (WRS) a rare genetic disorder that causes infantile insulin-dependent diabetes mellitus (IDDM) and often death in childhood from fulminant liver and concomitant kidney failure. WRS is characterized clinically through infantile IDDM, propensity for liver failure following viral infections, bone dysplasia and growth failure and developmental delay. Fewer than 60 cases with WRS are reported in the literature, mostly from consanguineous parents.
Liver transplants for non-alcoholics spurs drug search
Awareness of fatty liver disease that isn't caused by drinking is scant, even as it affects a fifth of the global population and up to 70 percent of people with type 2 diabetes. Non-alcoholic steatohepatitis, or NASH, is an advanced form that can lead to cirrhosis, where the liver hardens and stops working properly.
Study: Female kidney donors have increased risk of preeclampsia
By Chelsea Adams
Female kidney donors double their risk of developing preeclampsia during pregnancy, according to the results of a Canadian study published in the New England Journal of Medicine. While preeclampsia can pose serious health threats to the mother and fetus, the condition is usually manageable, and most women had uncomplicated pregnancies following nephrectomies. Previous studies about pregnancies following kidney donation have yielded conflicting findings about the health of the mother and fetus.
Missed our previous issues? See which articles your colleagues read most.
Liver transplant promising for HIV-positive cancer patients
Liver transplant is the best treatment option for people with HIV and hepatocellular carcinoma, a researcher said here. In a retrospective analysis, survival was markedly better for people who had a transplant rather than other potentially curative therapies, according to Heather Platt, M.D.
Renal outcomes of simultaneous liver-kidney transplantation compared to liver transplant alone for candidates with renal dysfunction
It is unclear whether a concomitant kidney transplant grants survival benefit to liver transplant (LT) candidates with renal dysfunction (RD). We retrospectively studied LT candidates without RD and LT candidates with RD who underwent either liver transplant alone or simultaneous liver–kidney transplant.
Early donor-specific antibodies in lung transplantation: Risk factors and impact on survival
The Journal of Heart and Lung Transplantation (login required)
The impact of early donor-specific anti-HLA antibodies (DSA) on patient and graft survival after lung transplantation remains controversial. In this study we analyzed risk factors for DSA that developed before initial hospital discharge after lung transplantation (early DSA) and compared mid-term outcomes in patients with or without DSA.
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