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Gene expression assay successfully predicts benign disease in indeterminate thyroid nodules
Endocrine Today
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A novel gene-expression classifier has been validated in reclassifying otherwise inconclusive results from thyroid biopsies as either benign or suspicious, according to data presented here at the Endocrine Society's 94th Meeting and Expo. The results were simultaneously published recently in the New England Journal of Medicine.
"Thyroid nodules are very common; this year alone, in the U.S., nearly half a million diagnostic fine-needle aspirations will occur in the work-up of these nodules. Though many of them are benign, there's about a 5 percent to 15 percent risk that any thyroid nodule is cancerous. So evaluation is recommended, though the current diagnostic methods are both imprecise and, at times, inaccurate,” Erik Alexander, M.D., study author and physician-researcher in the division of endocrinology, diabetes and hypertension at Brigham and Women's Hospital, said during a press conference.
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ATA advises thyroid collars not needed for mammography
AuntMinnie.com
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Thyroid collars are not need for mammograms, according to new guidelines on minimizing radiation dose issued on June 13 by the American Thyroid Association. However, the association advised a number of other steps to minimize unnecessary exposure to radiation from medical and dental imaging procedures, such as the use of collars for dental X-rays.
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TSH secreting tumors can be cured by long term octreotide treatment
Clinical Thyroidology
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A measurable serum TSH level in the presence of frankly increased FT4 and FT3 is a very unusual situation. It should direct the diagnosis either toward thyroid hormone resistance or toward a pituitary adenoma secreting TSH (TSHoma). The main differential diagnosis of TSHomas is resistance to thyroid hormones (generalized, peripheral, or central). In TSHomas, the basal α-subunit has a tendency to be slightly increased but not in resistance to thyroid hormones. MRI and a TRH test that shows a minimal increase of serum TSH and of its α-subunit can distinguish the two conditions. Genetic screening of the beta T3 receptor will usually establish the diagnosis of thyroid hormone resistance, even though there are some cases that have not been elucidated genetically. The TSHoma described here can be considered a classical case on grounds of both biologic and imaging results. The patient has been treated for four years with octreotide with shrinkage of the tumor and return to normal thyroid function even after stopping treatment.
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Nature-Throid™ is a natural alternative to synthetic thyroid medications. Most synthetic thyroid drugs often contain only T4 hormone. Nature-Throid™ contains two thyroid hormones, T4 and T3. Available by prescription in 13 strengths. more
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The AJCC TNM staging underestimates risk in young patients with more aggressive differentiated thyroid cancer
Clinical Thyroidology
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The differentiated thyroid cancer staging system of the American Joint Committee on Cancer uses age for staging the patient. Patients less than age 45 with distant metastases are stage II, while patients age 45 or older with metastases are stage IV. Although age is linked to prognosis, it may be too optimistic to classify younger patients in this way. This study examined the effect of age and disease extent in the AJCC staging system on mortality using survival data from the Surveillance, Epidemiology, and End Results rogram from 1973 to 2005 in order to determine whether the risk stratification accurately portrayed outcomes of DTC for young patients.
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India launches state-of-the-art system for monitoring salt iodization
ICCIDD
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India was one of the first countries in Asia
to implement salt iodization, with policies
dating back to the early 1960s. While the
country has made huge strides in increasing
iodized salt production in recent
years, progress has not always been steady.
A lift on the ban of sale of non-iodized
edible salt between 2000 and 2005 left
iodized salt use suspended at 51 percent
of households as per the National Family
Health Survey 3. The ban's 2005 reinstatement - combined with heightened
consumer awareness, effective monitoring,
and improvements in iodization practices
and packaging - helped to boost the
use of iodized salt from 51 percent of
households in 2005, to 71 percent by 2009
as per the UNICEF Coverage Evaluation
Survey that year.
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Natural form of parathyroid hormone decreased need for vitamin D, calcium in adults with hypoparathyroidism
Endocrine Today
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Adults with hypoparathyroidism responded well to recombinant natural human parathyroid hormone, rhPTH. According to results presented here, the drug reduced the need for large amounts of calcium and vitamin D supplementation.
"Many individuals with hypoparathyroidism are on very high amounts of calcium. Parathyroid hormone is the logical treatment for this disease, which is characterized by low or absent parathyroid hormone," John P. Bilezikian, M.D., professor of medicine and pharmacology at the College of Physicians and Surgeons at Columbia University, told Endocrine Today.
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ATA Thyroid Weekly News Briefs
ATA does not develop, exert any editorial or other control, or guarantee the accuracy, completeness, efficacy, or timeliness, of the materials, information, advertising or promotional activities ("Content") in this publication. Inclusion of Content in this publication does not constitute or imply endorsement, agreement, recommendation, or favoring by ATA of such information or the entities mentioned or promoted herein. Use of any Content appearing or referenced in this publication or obtained from advertisers is voluntary, and reliance on it should only be undertaken after an independent review by qualified experts. ATA is not responsible for, and expressly disclaims all liability for, damages of any kind arising out of use of, reference to, reliance on, or performance pursuant to such Content.
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