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GENOMICS


Scientists identify new gene that drives triple-negative breast cancer
Medical News Today
In a new study, researchers from the U.K. have discovered a novel gene that, when mutated, can drive development and progression of triple-negative breast cancer — an aggressive form of the disease that accounts for 10-20 percent of breast cancers.
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Genes may help identify children with future psychological problems
Fox News
New research has found that children with a certain common gene variant were more likely to develop serious problems as adults, potentially paving the way to personalized treatments for troubled children. The study, from Duke University, draws on two decades’ worth of data on high-risk first-graders from four locations across the U.S.
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Study IDs 2 genes that boost risk for post-traumatic stress disorder
Medical Xpress
Why do some people develop post-traumatic stress disorder while others who suffered the same ordeal do not? A new UCLA discovery may shed light on the answer. UCLA scientists have linked two gene variants to the debilitating mental disorder, suggesting that heredity influences a person's risk of developing PTSD.
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BIOTECH/DIAGNOSTICS/PERSONALIZED MEDICINE


Researchers discover personalized therapy for cardiovascular disease
Drug Discovery & Development
Researchers at the Montreal Heart Institute announced results showing that patients with cardiovascular disease and the appropriate genetic background benefit greatly from the new medication dalcetrapib, with a reduction of 39 percent in combined clinical outcomes including heart attacks, strokes, unstable angina, coronary revascularizations and cardiovascular deaths.
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Big opportunities exist for cancer research and treatment, but challenges lie ahead
Genetic Engineering & Biotechnology News
Over the past year we have seen dramatic advancements in personalized medicine, particularly in the field of oncology. The industry has made strides in areas ranging from genetic stratification and biomarker identification to diagnostics, targeted therapies, and prognostic tests. As we look toward 2015 the bar will be set even higher, and major opportunities are on the horizon for personalized medicine and cancer research and treatment.
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PRODUCT SHOWCASE
  Advancement revolutionizes hereditary cancer testing

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Deals for genetic data raise issues of privacy, sharing
Bloomberg
In three recent deals, drugmakers are betting that personal genetic maps will finally fulfill their early promise to unlock secrets and cure diseases. At the same time, the agreements revived questions about privacy protections and how useful personal genetic data will prove to be.
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REGENERATIVE MEDICINE


Most MS patients who received stem cell transplants still in remission years later
Healthline
Most of the multiple sclerosis patients who took part in the cutting-edge stem cell study HALT-MS are still in remission years later. The phase 2 study has demonstrated impressive results by rebuilding the immune system using a patient’s own stem cells.
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Eye surgeon uses stem cells to repair damaged corneas
Medical Xpress
In Hyderabad, India, Sayan Basu is using stem cells in a pilot project to restore the eyesight of patients with damaged corneas. If proven successful, the procedure could mean that Indian citizens can avoid long waiting lists for cornea transplants and avoid eye surgery altogether.
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Improving stem cell therapy in older patients
Genetic Engineering & Biotechnology News
The clinical effectiveness of stem cell therapy has been, to say the least, modest. Part of this may be the result of the advanced age of some patients or the effects of chronic diseases such as diabetes and cardiovascular disease, say researchers in a review article published in BioResearch Open Access.
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EMERGING MEDICAL TECHNOLOGIES


Venture capital dollars pouring into digital health industry
By Scott E. Rupp
Venture funding played a large part in advancing the work of digital health companies in 2014, accounting for a record-breaking $4.1 billion in investments, according to startup accelerator Rock Health. The level of investment surpassed the total of the three previous years combined. Despite these numbers, a variety of other, sometimes-conflicting investment levels were reported throughout 2014. But one thing is clear: There's a great deal of activity surrounding health IT, and more is expected to come in the near term from investors.
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An old-school fix to doctors' tech woes: Medical scribes
FORTUNE
A booming health care profession is helping ease doctors’ frustration with growing digital demands. Three years out of residency, Kevin Hopkins, the medical director of a family health and ambulatory surgery center in Strongsville, Ohio, was buried in emails, phone calls and patient notes. And as a self-described “poor typist,” he was repeatedly foiled by his office’s electronic health record system. All that made it near impossible to focus on his main task: Examining the 18 to 25 patients that visited him every day.
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New ultrasound tech changes healthcare
WWL-TV
Thousands of doctors are in New Orleans from around the world to see the latest medical technology at the International Meeting on Simulation in Health Care at the New Orleans Convention Center. Now, new software used on real patients and mannequins can be used to train medical professionals to diagnosis and treat patients better and faster.
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FDA: NEW TREATMENTS AND TECHNOLOGY


FDA informs Arrowhead of partial clinical hold for hepatitis B drug
The Wall Street Journal
Arrowhead Research Corp. said that U.S. regulators informed the company of a partial clinical hold for a potential hepatitis B treatment. The news sent shares of Arrowhead down nearly 22 percent in recent premarket trading. The company said the Food and Drug Administration told it during a preliminary call that it placed a partial clinical hold on testing ARC-520 in patients suffering from chronic hepatitis B.
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FDA to study limiting lists of drug risks in TV ads
The Hill
The Food and Drug Administration wants to study how consumers would respond to prescription dug TV ads that list only a limited number of a product’s side effects. Regulations now require direct-to-consumer prescription drugs advertisements aired on TV and radio to list the products’ major risks in an audio or an audio and visual part of the ad.
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23andme aims to end FDA standoff this year after public shaming
Bloomberg
23andMe Inc., the genetic-testing startup, is pushing to get its first agreement with U.S. regulators on a test for a disorder by this year, a turnabout after being criticized by the U.S. Food and Drug Administration for not cooperating with its approval process.
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ACCOUNTABLE CARE ORGANIZATIONS


Accountable care, patient portals lag behind expectations
Health IT Analytics
The purpose of an accountable care organization is for physicians, hospitals and other medical facilities to collaborate, working together to improve population health and to work towards value-based reimbursement. The expansion of these groups attempt to foster community health and coordinated care. Four organizations have formed new ACOs, entered into new ACOs, or entered into new ACO agreements in the past week.
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MANAGED HEALTHCARE NEWS


Eligible Americans turn down Obamacare tax credits
U.S. News & World Report
Grace Brewer says she never thought she would be without health insurance at this stage of her life. "I'm a casualty of Obamacare," says Brewer, 60, a self-employed chiropractor in the Kansas City, Kansas, area. She wanted to keep the catastrophic health insurance plan she once had, which she says fit her needs.
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US is falling behind on medical research: What's the hold up?
Tech Times
Medical research in the United States is falling behind other nations, which could hinder advances in the fight against disease, according to a study published by the American Medical Association. Medical research funding from the federal government in the United States has fallen over the last several years.
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FAST FACTS
"The flu is a contagious respiratory illness caused by influenza viruses that infect the nose, throat, and lungs. It can cause mild to severe illness, and at times can lead to death. The best way to prevent the flu is by getting a flu vaccine each year."


TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Study: Gene linked to obesity hasn't always been a problem (The New York Times)
Are your political views in your genes? (Forbes)
Whale genes offer hints to longer lifespans (Live Science)
Scientists explain how stem cells and 'bad luck' cause cancer (Los Angeles Times)
The most exciting health tech at CES? Adhesive bandages (PC Magazine)

Don't be left behind. Click here to see what else you missed.
 

Genomics Biotech and Emerging Medical Technologies Institute eBrief
Colby Horton, Vice President of Publishing, 469.420.2635
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Natalie Rodriguez, Senior Content Editor, 469.420.2635   
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