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GENOMICS


Autism genomes add to disorder's mystery
Los Angeles Times
Less than a third of siblings with autism shared the same DNA mutations in genes associated with the disorder, according to a new study that is the largest whole-genome sequencing for autism to date. Canadian researchers sequenced whole genomes from 170 siblings with autism spectrum disorder and both their parents.
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How genes and environment conspire to trigger diabetes
LiveScience via Fox News
Diabetes appears to be a disease written deeply in human genes, a feature millions of years old, which can emerge yet also retreat through the influence of environmental forces such as diet, a new study suggests. Researchers looked at how obesity, in particular, can trigger the onset of Type 2 diabetes in both mice and humans by manipulating how genes are expressed.
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SPONSORED CONTENT


Cracking the brain's genetic code
The Huffington Post
An international team of over 300 scientists are taking on an ambitious project to identify eight common genetic mutations that appear to age the brain by three years on average. The team, known as Enhancing Neuro Imaging Genetics through Meta Analysis Network, hopes to pave the way for new treatments for Alzheimer's, autism and other neurological disorders.
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BIOTECH/DIAGNOSTICS/PERSONALIZED MEDICINE


'Personalized' CPR increases survival from cardiac arrest
Medscape
The use of diastolic blood pressure and end tidal carbon dioxide measures to guide in-hospital cardiopulmonary resuscitation is associated with a significant improvement in the chance of survival from cardiac arrest, according to new research. "Healthcare providers need to monitor how the patient is responding to the resuscitation effort," said lead investigator Robert Sutton, M.D., from the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia.
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PRODUCT SHOWCASE
  5 Must-Track Metrics for Practice Profitability

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Obama's precision medicine initiative stirs hope, caution
Los Angeles Daily News
There was talk of taxes and economics, a call for more federal spending on child care and equal wages for women. But tucked away in President Barack Obama’s State of the Union address were a few sentences that left medical researchers sitting at the edge of their seats. “I want the country that eliminated polio and mapped the human genome to lead a new era of medicine, one that delivers the right treatment at the right time,” Obama said.
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REGENERATIVE MEDICINE


Human stem cells could one day be regulated to replace aged, damaged, and missing tissues
Medical Xpress
When a salamander loses a tail, it grows a new one. What's the difference, MIT biologist Peter Reddien, Ph.D., wondered. Tweaking a gene or injecting a drug to repair damaged or aging organs, muscles, nerves or brain tissue is one of the most enticing medical scenarios imaginable — a scenario that Reddien, an associate professor and associate department head of biology and a Howard Hughes Medical Institute investigator, hopes will one day make the leap from fiction to science.
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PRODUCT SHOWCASE
  Advancement revolutionizes hereditary cancer testing

Myriad myRisk™ Hereditary Cancer utilizes both genetic test status AND personal cancer family history to identify elevated risk for 8 important cancers by analyzing multiple, clinically significant genes. Myriad myRisk improves clinical sensitivity by 40-50% compared to current testing paradigms in a cost-effective manner, providing more value to your members.
 


BPA exposure may change stem cells, lower sperm production
Scientific American
BPA and other estrogenic compounds hamper development of the stem cells responsible for producing sperm in mice, which suggests such exposure could contribute to declining sperm counts in men, according to a new study. The study, published in PLoS Genetics, is the first to suggest that low, brief exposures to bisphenol-A, or other estrogens such as those used in birth control but found as water contaminants, early in life can alter the stem cells responsible for producing sperm later in life.
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Manchester researcher discover novel way to eradicate cancer stem cells
News-Medical.net
A way to eradicate cancer stem cells, using the side-effects of commonly used antibiotics, has been discovered by a University of Manchester researcher following a conversation with his young daughter. Professor Michael P. Lisanti, Director of the Breakthrough Breast Cancer Unit, led the research.
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EMERGING MEDICAL TECHNOLOGIES


Millennials are reshaping healthcare
By Scott E. Rupp
Global consumer collaboration consultancy Communispace recently released a report called, "Healthcare without Borders: How Millennials are Reshaping Health and Wellness," which examines millennial healthcare values and how they will impact businesses across the industry. The report focuses on several areas of millennials' lives, including technology. Millennials are far more likely than other generations to rely on mobile and online tools to monitor and maintain their health, the report states.
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FDA: NEW TREATMENTS AND TECHNOLOGY


FDA approves fixed-dose combination for patients with hypertension
Healio
Symplmed Pharmaceuticals announced that the FDA has approved the fixed-dose combination of perindopril arginine and amlodipine for the treatment of hypertension in patients whose BP is not adequately controlled on monotherapy.
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FDA approves hormone treatment for hypoparathyroidism
Pharmacy Times
The FDA has approved NPS Pharmceuticals’ parathyroid hormone, a once-daily hormonal injection to control low blood calcium levels in patients with hypoparathyroidism. Hypoparathyroidism is a disease in which the parathyroid glands produce an insufficient amount of parathyroid hormone, which helps to regulate calcium and phosphorus levels in the body.
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ACCOUNTABLE CARE ORGANIZATIONS


Accountable care, patient portals lag behind expectations
EHR Intelligence
The slow uptake of accountable care reimbursement structures and the low implementation rates of advanced patient portals are among some of the top issues in healthcare over the past year, according to HIMSS Analytics, and present both challenges and opportunities for the industry as it moves forward into reforms that encourage patient engagement, individualized care, and higher quality outcomes.
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Can life sciences companies evolve to accountable care?
HIT Consultant
Healthcare providers continue to assume increasing amounts of risk in care delivery. This has major implications, not just for providers and patients, but also vendors in IT, diagnostics, therapeutics and devices. If providers assume risk, why shouldn’t their vendors?
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Miss an issue of Genomics Biotech and Emerging Medical Technologies Institute eBrief? Click here to visit the archive page.


MANAGED HEALTHCARE NEWS


The medical world is changing — How can we keep up?
By Joan Spitrey
Healthcare is a dynamic industry. It is constantly changing as new modalities, treatments and technologies are discovered or even rebutted. Even with the changes in technology, diagnostics and treatments, the healthcare environment has stayed relatively static. The patient seeks treatment, and the healthcare provider treats based on the needs of the patient. The provider of care bills for services and is paid. For the most part, the healthcare providers have wielded most of the control with little resistance. However, this is changing, and the power has shifted.
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Is Obamacare about controlling our lives?
CNN
Journalist Steven Brill has written a new book about our dysfunctional system of healthcare and it's getting a lot of attention. In "America's Bitter Pill: Money, Politics, Backroom Deals, and the Fight to Fix Our Broken Healthcare System," he describes the various struggles to implement the Affordable Care Act and dissects the ongoing opposition to the bill.
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FAST FACTS
"Heart disease is the leading cause of death and a major cause of disability in the United States. About 600,000 Americans die of heart disease annually. "


TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Early study: Stem cells may reverse MS disability (HealthDay News via WebMD)
Donated embryo leads to stem cell line that generates nerve cells (Medical Xpress)
Schizophrenia: 8 genetic diseases shoved into 1 diagnosis with varied likelihood of escaping mental illness development (Inquisitr)
Scientists identify gene mutations that put people at risk of heart failure (Reuters via The Huffington Post)
New technologies put the patient 1st (Fox News)

Don't be left behind. Click here to see what else you missed.
 

Genomics Biotech and Emerging Medical Technologies Institute eBrief
Colby Horton, Vice President of Publishing, 469.420.2635
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Natalie Rodriguez, Senior Content Editor, 469.420.2635   
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