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We wanted you to be aware that the FDA has granted accelerated approval of IBRANCE® (palbociclib) for the treatment of postmenopausal women with ER+/HER2- advanced breast cancer. Click here to see the press release!
Otezla® (apremilast) is approved for the treatment of patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy. Please click here for more information.
OAs part of APhA's longstanding and ongoing commitment to helping its members ensure optimal and safe patient use of prescription medications, nonprescription products, and dietary supplements, APhA convened national pharmacy and medicine leaders and other stakeholders on March 26.
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Tool to analyze genes according to their evolutionary profiles
Two major revolutions, one genomic and one in informatics, are completely changing the face of biomedical research. Every day all over the world, millions of genetic sequences — from disease-related genes to complete genomes of plants, animals, bacteria and viruses — are resolved, identified and dissected.
Scientists find a gene that regulates sleep
Flies, it turns out, sleep about as much as young children do. Males need about 12 hours a day, while females can do with about 10 hours. To find out which genes might be responsible for guiding how much slumber flies get a night, Kyunghee Koh did a massive experiment that you can only do with fruit flies.
Faster, not stronger: How a protein regulates gene expression
By measuring the motion of single molecules, EPFL scientists have discovered how specialized proteins control gene expression by binding and compacting discrete parts of DNA inside the cell. The findings have significant implications for genetics and cancer research.
Conquering cancer: Personalized medicine is the future
The Huffington Post
Personalization is threaded into the social fabric of America. Innovation is rooted in customizing and personalizing even the smallest parts of our lives, stemming from technology and retail to travel, media and wellness. The future continues to promise even smarter applications where personalization fits, but what about our health?
BioFeedback for immunoglobulin is a health outcomes reporting program that provides clinical feedback on the use of immunoglobulin in autoimmune-related disorders. Physicians and medical directors can now deploy clinical interventions when they have the greatest impact on healthcare quality and costs.
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Do advocates overestimate the benefits of personalized medicine?
The advocates of personalized or precision medicine may have set up unrealistic expectations about its promise while leaving many questions unanswered, according to a viewpoint article in the Journal of the American Medical Association.
"Even though personalized medicine will be useful to better understand rare diseases and identify novel therapeutic targets for some conditions, the promise of improved risk prediction, behavior change, lower costs, and gains in public health for common diseases seem unrealistic," wrote Michael J. Joyner, M.D., department of anesthesiology, Mayo Clinic in Rochester, Minnesota, and Nigel Paneth, M.D., department of epidemiology and biostatistics, College of Human Medicine, Michigan State University.
Stem cells show promise as treatment for diabetic neuropathy
Genetic Engineering & Biotechnology News
A scientific team from the U.S. and Korea reports that laboratory rats models of diabetic neuropathy can experience both angiogenesis and nerve remyelination following injections of mesenchymal stem cells derived from bone marrow. The study, which will be published in a future issue of Cell Transplantation, is currently available online.
Researchers mass-producing stem cells to satisfy the demands of regenerative medicine
Steve Oh had been growing stem cells by conventional means at the A*STAR Bioprocessing Technology Institute for seven years, when in 2008 his colleague Shaul Reuveny proposed an idea for speeding up the process.
Instead of culturing the cells on round, flat Petri dishes, he could try growing them on tiny polystyrene beads known as microcarriers floating in a nutritional brew, suggested Reuveny, a visiting scientist at the BTI.
EMERGING MEDICAL TECHNOLOGIES
The versatile e-nose detects everything from cat-poop coffee to cancer
The electronic nose, or e-nose, has been around for a while lending a super-sensory hand in some surprising places.
The e-nose has proven itself time and again in the world of agriculture. A recent Chinese study determined e-noses to be as good as a gas chromatograph mass spectrometer at identifying different varieties of eggs to prevent counterfeiting and shady dealings — such as vendors passing off readily available quail eggs as the more preferred pigeon eggs.
Sen. Lamar Alexander identifying strategies for better EHR program
By Scott Rupp
Senate Health Committee Chairman Lamar Alexander (R-Tenn.) has been busy, and remains so. Earlier this month, he announced that he would conduct a series of hearings intended to solve problems with the federal government’s six-year-old, $30 billion program meant to encourage adoption of electronic health records at medical offices and hospitals. The hearings come after the Centers for Medicare and Medicaid Services claimed in December 2014 that a quarter of a million physicians had not been able to comply with the program’s second phase and have begun losing 1 percent of their Medicare payments.
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Study: Digital health solutions may save US health system $100 billion
By Scott E. Rupp
Accenture, in a new report, estimates that FDA-approved digital health solutions — an Internet-connected device or software created for detection or treatment of a medical indication — may have saved up to $6 billion in cost savings last year, primarily driven by medication adherence, behavior modifications and fewer emergency room visits. And digital health solutions are expected to save the U.S. healthcare system an additional $100 billion over the next four years.
ACCOUNTABLE CARE ORGANIZATIONS
Slow going on ACO risk
Even as participation in ACOs grows, providers are hesitant to advance to models with more risk. CMS has now extended the least risky ACO track for three more years.
The Centers for Medicare & Medicaid Services can point to growing numbers of accountable care organizations as an indicator that healthcare providers are using ACOs to shift from volume to value-based care.
Clinical, patient engagement key to ACO success
Implementing an accountable care organization is nearly impossible without high-quality clinical engagement, according to a panel of healthcare leaders at Friday's sixth annual National ACO Summit in the District of Columbia.
And that engagement requires clinical leadership among the workers who are directly involved in care delivery, including physicians, non-physician providers, clnical staff and clerical employees, said Terry McGeeney, M.D., president of Care Accountability, Inc., and a visiting scholar at the Brookings Institution, who served as the moderator of the panel.
FDA: NEW TREATMENTS AND TECHNOLOGY
Public rarely knows full reason FDA rejects new drugs
Reuters via MedPage Today
Drug companies generally don't disclose all the reasons new medicines fail to win U.S. marketing approval, even though regulators often reject treatments over concerns about safety or effectiveness, a study finds.
Researchers compared the details companies made public in press releases with confidential documents from the U.S. Food and Drug Administration known as complete response letters, which explain why a new medicine can't be sold.
FDA approve device that helps blind 'see with tongue'
Medical News Today
When used with a cane or assistance dog, the BrainPort V100 can enhance people's ability to navigate their environment by literally "tasting the light."
The battery-powered BrainPort looks like a square plastic lollipop — this goes in the mouth and sits on the tongue — connected via a wire to a tiny video camera mounted on a pair of sunglasses that the user wears.
Medical insurance is good for financial health, too
The New York Times
People who have health insurance have less health-related financial stress. That’s a not-so surprising finding from a recent survey from the Centers for Disease Control and Prevention.
There’s good reason to expect the Affordable Care Act to reduce financial strain. Exposure to healthcare costs fell for those who gained coverage, as it has for those whose coverage became more generous, too.
Health mergers could cut consumer options
The Wall Street Journal
The nation’s biggest health insurers, which are pursuing a series of potential megamergers, have market overlaps that could damp competition in sectors such as private Medicare plans, an analysis of state and federal data by The Wall Street Journal has found.
The board of Cigna Corp. on Sunday rejected a $47.5 billion bid from Anthem Inc. that was disclosed on Saturday. Aetna Inc. has made an offer for Humana Inc. in recent days.
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