Under the Microscope
Apr. 16, 2014

7th Annual Summer Symposium — Baltimore
NSH has partnered with the states of Region II to bring the 7th Annual Summer Symposium to the Charm City of Baltimore! Join us June 13-14 for general sessions and workshops featuring expert speakers will provide you with the tools, advice and guidance you seek in your professional career. The Summer Symposium is one of the best values for your training dollars in histology education offering 12 continuing education credits and an Exhibit Fair for one low price! Click here for a complete schedule.More

NSH Laboratory Webinar: Immunohistochemistry Staining for Orphan Metastic Tumors (Metastasis from Unknown Primary)
Tumors from their primary/origin sites often metastasize to other tissues and organs in the body, and in some instances this may be the first clinical presentation of this tumor. Join Dr. Mitual Amin on April 23, to discuss a somewhat simplified approach as to how pathologists may order certain panels of antibodies and their assessments. This presentation will help participants become aware of the existence of such tumors, and the utility and limitations of these immunohistochemical tests in this setting. Register now.More

Targeting cancer with a triple threat
Massachusetts Institute of Technology via R&D Magazine
Delivering chemotherapy drugs in nanoparticle form could help reduce side effects by targeting the drugs directly to the tumors. In recent years, scientists have developed nanoparticles that deliver one or two chemotherapy drugs, but it has been difficult to design particles that can carry any more than that in a precise ratio. Now Massachusetts Institute of Technology chemists have devised a new way to build such nanoparticles, making it much easier to include three or more different drugs.More

Study examines biomarkers in HPV negative squamous-cell carcinomas of the head and neck
A quartet of proteins that play critical roles in cell replication, cell death, and DNA repair could lead to better targets for therapy against treatment-resistant head-and-neck squamous cell cancers. In a study to be presented at the recent AACR Annual Meeting 2014, Ranee Mehra, M.D., a medical oncologist who specializes in head and neck cancers at Fox Chase Cancer Center, and colleagues, showed a correlation between the expression levels of these proteins in head-and-neck cancers negative for human papilloma virus. These tumors have a poorer prognosis than HPV-positive head-and-neck cancers. More

New technique of single-cell genomic analysis to reverse tissue engineering
Consider the marvel of the embryo. It begins as a glob of identical cells that change shape and function as they multiply to become the cells of our lungs, muscles, nerves and all the other specialized tissues of the body. Now, in a feat of reverse tissue engineering, Stanford researchers have begun to unravel the complex genetic coding that allows embryonic cells to proliferate and transform into all of the specialized cells that perform a myriad of different biological tasks.More

New method to isolate immune cells allows researchers to study how they ward off oral diseases
Case Western Reserve University dental researchers have found a less invasive way to extract single rare immune cells from the mouth to study how the mouth's natural defenses ward off infection and inflammation. By isolating some specialized immune cells (white blood cells known as "leukocytes") to study how they fight diseases in the mouth — or reject foreign tissues, such as in failed organ transplants — researchers hope to learn more about treating and preventing such health issues as oral cancers, cardiovascular disease, AIDS and other infectious diseases. More

No 'ideal' tissue for gene expression studies of autism
Simons Foundation Autism Research Initiative
Measuring RNA expression from individual genes provides one route to novel insights in understanding human disorders such as autism. For example, it may reveal the impact of a genetic mutation on the gene itself or its indirect consequences on the expression of other genes. Patterns of RNA expression can also help to define genetic networks and to reveal the effects of perturbing these systems. Applying network approaches over time can also inform us about the disorder and how it progresses.More

Lipid-based protein delivery system efficiently transports proteins into living cells
BioPORTER is the first and only lipid-based protein delivery system that efficiently transports proteins into living cells. Comprising a unique cationic lipid mixture that interacts non-covalently with the protein, BioPORTER creates a protective vehicle for immediate protein delivery. BioPORTER makes studying protein functionality faster and easier than ever before by bypassing the traditional DNA transfection, transcription, and protein translation processes.More

Sharpening microscope images: New technique takes cues from astronomy, ophthalmology
Fars News Agency
The complexity of biology can befuddle even the most sophisticated light microscopes. Biological samples bend light in unpredictable ways, returning difficult-to-interpret information to the microscope and distorting the resulting image. New imaging technology rapidly corrects for these distortions and sharpens high-resolution images over large volumes of tissue.More

Excluding drug companies from drug information dissemination
By Mike Wokasch
For the past couple of decades, the healthcare market has gradually made it more difficult for drug companies to market their products. As a result, drug company marketing has tried to reach prescribers, formulary decision-makers and even patients with a variety of nonsales rep tactics, including Internet advertising, social media and television ads. So why is all this important? Don't doctors know how to prescribe drugs? Aren't there prescribing guidelines and best practices? More importantly, shouldn't doctors know how to treat patients without pharmaceutical company influence?More