Under the Microscope
July 14, 2011

Moving anatomic pathology closer to patient yields benefits, opportunities for professionals
ADVANCE for Medical Laboratory Professionals
Laboratory medicine is constantly evolving. Recently, anatomic pathology laboratories have been installed in the offices of specialty practice physician groups. While some controversy exists surrounding this trend, movement of labs closer to the patient yields benefits for the patient and opportunities for technologists, histologists and pathologists.More

Health of pathology laboratory technicians at risk from common solvents
Dark Daily
Researchers determined that medical laboratory technicians who handle common solvents develop auto-immune connective tissue diseases in increased numbers. The new study was published in the Journal of Rheumatology. It offers credible evidence that clinical laboratory technicians, pathologists, and scientists who work with toluene and xylene double their chances of developing a vascular condition known as Raynaud's phenomenon.More

Under the Microscope on the go: Download the free MultiBriefs app
NSH understands the need to deliver timely, relevant news to its members. In partnering with MultiBriefs to create NSH Under the Microscope, the association committed itself to providing updates on a weekly basis. NSH Under the Microscope is also available on the MultiBriefs app, available for the Apple iPhone and iPod Touch in the App Store. Simply search "MultiBriefs" and download the app free of charge. After it's downloaded, you may add the NSH feed. News is streamed into your iPhone or iPod Touch each week. Android phone users may also access the app by going to the Android Marketplace and searching "MultiBriefs" to access the Android version of the app.More

New eosinophilic esophagitis guidelines update diagnosis, therapy
Internal Medicine News
New clinical guidelines for eosinophilic esophagitis characterize the disorder as a chronic, immune- and antigen-mediated disease. The updated consensus recommendations, which constitute the first update since 2007, also suggest that eosinophilic esophagitis is truly on the rise in both adults and children, although no one really knows why. The guidelines also suggest that the disease may have a genetic underpinning — an abnormality in chromosome 5. More

Medical center adds less invasive biopsy
OSF St. Joseph Medical Center is offering stereotactic breast biopsies — a safe, fast and precise way to test breast tissue samples without surgery. "Stereotactic breast biopsies can be less stressful, with minimal risk of complications in comparison to open surgical biopsy," said Lisa Stevens, director of Cardiology and Medical Imaging.More

CMS to conduct public meeting on genetic, molecular lab test billing
Dark Daily
Changes in how the Medicare program will reimburse pathology groups and clinical laboratories for genetic tests and molecular diagnostic assays will be one of the important topics at an upcoming meeting in Baltimore. The federal Centers for Medicare and Medicaid Services will conduct the meeting at its headquarters and is asking for public comment as it develops coverage guidelines and reimbursement levels for the 2012 laboratory test fee schedule.More

Dual-cooling freezer protects valuable samples
Laboratory Talk
Sanyo has expanded its offering of dual-cooling -86C freezers with the MDF-U700VX, an upright 728-litre model that is said to provide maximum sample security for research and clinical samples. Sanyo said that with two independent refrigeration systems, its dual-cooling freezers maintain a reliable and uniform -86C ultra-low temperature environment; if one cooling system suffers an unexpected failure, the other circuit will keep samples safe until service can be arranged.More

Enhanced immunohistochemical resolution of claudin proteins in glycolmethacrylate-embedded tissue biopsies
There are a number of disadvantages with conventional tissue immunohistochemistry for accurate localization of claudin proteins. The use of glycolmethacrylate tissue embedding with fixation in acetone is compatible with epitope preservation for many antibody reagents that are often destroyed by chemical cross-linking fixatives.More

Cellular origin of deadly brain cancer is identified
Using a mouse genetic system co-developed by researchers at the University of Oregon and Stanford University, a research team led by UO biologist Hui Zong has isolated the cellular origin for malignant glioma, a deadly human brain cancer. Zong and his team made the discovery by using Mosaic Analysis with Double Markers, developed for studying developmental biology and modeling diseases in mice.More

ERG oncoprotein overexpression in prostate cancer
Medical Laboratory Observer
The high prevalence of gene fusions involving the ERG gene and the specificity of ERG oncoprotein overexpression for prostate cancer has led to a body of research on clinical applications for diagnosis and treatment. Research suggests that the ERG oncoprotein overexpression has oncogenic functions in prostate cancer, increasing tumor cell invasion, abrogating prostate cell differentiation and acting as a surrogate marker of androgen receptor signaling defects.More

Low adherence to biopsy guidelines affects celiac disease diagnosis in US
Columbia University Medical Center via PR Newswire
A new study has found that most patients undergoing biopsy of the small intestine do not have the recommended four samples to diagnose celiac disease. The study, published in Gastrointestinal Endoscopy, analyzed a national database of biopsy specimens. More than 100,000 patients had a biopsy of the small intestine, but only 35 percent of them had at least four samples taken.More

Scientists identify marker that enables segregation of true human hematopoietic stem cells from multipotent progenitors
Genetic Engineering & Biotechnology News
Scientists claim to have identified markers that enable the segregation of rare, truly pluripotent human hematopoietic stem cells from multipotent progenitors. They identified CD49f as a specific marker for pluripotent HSCs, enabling their isolation using flow cytometry. The team at the Campbell Family Institute for Cancer Research/Ontario Cancer Institute tracked the expression of a number of adhesion molecules in HSC-enriched subsets. More

Novel multi-color immunofluorescence technique using primary antibodies raised in the same host species
SoluLink via BioCompare
In order to avoid cross-reactivity of secondary antibodies with unwanted primary antibodies when doing either dual- or triple-labeling immunofluorescence it is necessary to use primary antibodies raised in different host species. In this clinical report, the authors describe their technique for triple-labeling immunofluorescence that can be used with primary antibodies derived from a single host source.More