Under the Microscope
Sept. 7, 2011

Researchers discover gene defect that predisposes people to leukemia
A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene. Among its several regulatory roles, the gene acts as a master control during the transition of primitive blood-forming cells into white blood cells. More

Tube burgers: The world of in vitro meat
Imagine picking up a nice juicy burger and taking a bite, only to find out that the meaty burger you're biting into didn't come from an animal — it was grown in a lab. Scientists at laboratories around the world are currently working to make meat in labs that will eventually look and taste like the real thing, without any animal parts.More

Symposium/Conference attendees can earn Certificate of Completion in IHC, management or safety
Not only can NSH Symposium/Conference attendees earn necessary continuing education hours but they can also earn the NSH Certificate of Completion in immunohistochemistry, management or safety. Participants who attend the required hours of training are provided a certificate with practical, applicable skill documentation that can be used to enhance marketability within your organization or in the job market.

To receive a Certificate of Completion, attendees must accrue a minimum of nine credit hours (three, half-day workshops) in one of the three subject areas. The certificate is provided to all who qualify at no cost.

For complete information on the program and to see which workshops qualify, please visit the NSH website.

To register for the Symposium/Convention, click here.More

Quality Management for the Histology Lab Forum to be held in Austin, Texas
Are you controlling, ensuring and improving Quality? Do you have a process that encompasses and links every aspect of your lab? Do you struggle with the constant attention needed? What specific tools are needed to ensure each employee can create the highest quality, consistently, for each task? Do you understand why Quality Management is crucial to success in today’s laboratory?

Attend the NSH Quality Management Forum on Oct. 22 in Austin, Texas, to answer these questions and more. Topics will include Standardization: Start to Finish, Method & Process Validation, Creating the Quality Chain and The Histology Lab and ISO15189.More

Hope for best, plan for worst: Dust off terrorism preparedness procedures
ADVANCE for Medical Laboratory Professionals
During the past 10 years, it seems that the frequency of emergency preparation activities in both the private and public sections has appeared to dwindle. There is a visible decrease in the amount of preparedness workshops, mock drills and training articles. However, it would seem wise to not forget that in this new global reality, the probability of another terrorist attack is high. And as a result, it is not a matter of "if" an event will occur, but rather "when." More

Biomarkers flunk Alzheimer's test
MedPage Today
Changes in cognitive function outperformed biomarkers for predicting conversion from mild impairment to Alzheimer's disease, a retrospective review of medical records showed. Two measures of verbal memory provided the most predictive information. Middle temporal lobe cortical thickness on neuroimaging also predicted conversion from mild cognitive impairment to Alzheimer's disease over a two-year period.More

In cell culture, like real estate, the neighborhood matters
Bioscience Technology
Ever since scientists first began growing human cells in lab dishes in 1952, they have focused on improving the chemical soup that feeds the cells and helps regulate their growth. But one scientist says surfaces also matter. Laura Kiessling, a professor of chemistry at the University of Wisconsin-Madison, observes that living cells are normally in contact with each other and with a structure called the extracellular matrix, not just with the dissolved chemicals in their surroundings.More

Patient safety awareness survey
SaferPath is seeking to understand professionals' perspectives on pathology lab errors, their consequences and solutions. Through this survey, it hopes to build safer pathology labs.More

Siemens to develop assays to aid in diagnosis of preeclampsia
Siemens via ADVANCE for Medical Laboratory Professionals
Siemens Healthcare Diagnostics has entered into a global licensing agreement with Nephromics, LLC to develop two assays to be used as an aid in the diagnosis of preeclampsia, a potentially life-threatening condition that occurs during pregnancy and affects both mothers and their unborn children. The assays are being developed for the detection of two biomarkers, soluble fms-like tyrosine-kinase-1 and placental growth factor.More

New form of colitis seen with cord blood transplant
Medpage Today
A new syndrome characterized by watery diarrhea has been identified in a group of patients who underwent cord blood stem cell transplantation. The condition, termed cord colitis syndrome, developed in 11 of 104 patients, according to a retrospective study. All cases were responsive to antibiotic treatment although no infecting.More

Separate HPV16, HPV18 testing may identify high-risk women
Medscape News Today (free registration required)
Compared with cytology testing, separate testing for human papillomavirus 16 and HPV18 may offer improved detection of women at high risk for cervical cancer, according to the results of a study. "HPV testing with separate HPV16 and HPV18 detection could provide an alternative, more sensitive and efficient strategy for cervical cancer screening than do methods based solely on cytology," the study authors write.More

Snapback primer genotyping of the Gilbert syndrome, promoter polymorphism by high-resolution melting
Clinical Chemistry
Gilbert syndrome is associated with thymine-adenine insertions in the UGT1A1 promoter. The UGT1A1 promoter genotype also correlates with toxicity induced by the chemotherapeutic drug irinotecan. Current closed-tube assays for genotyping the UGT1A1 promoter polymorphism require multiple labeled probes.More

Finding cancer in saliva
Laboratory Equipment
A new saliva test can measure the amount of potential carcinogens stuck to a person's DNA-interfering with the action of genes involved in health and disease-and could lead to a commercial test to help determine risks for cancer and other diseases.More

Examining magnitude, special settings, diagnostic testing of asymptomatic and symptomatic urinary tract infections
ADVANCE for Medical Laboratory Professionals
From a microbiological view point, urinary tract infection is indicated when pathogenic microorganisms are found in the urine, bladder, urethra, kidney and prostate and a microorganism growth of greater than 105 per mL is isolated from a mid-stream or clean catch urine specimen. Asymptomatic urinary tract infection is the absence of symptoms in a patient having urinary tract infection. The presence of symptoms in a patient having infection of the urinary tract is referred to as symptomatic urinary tract infection.More