Design Studio14 May 2013 17:06:12 CDTEye on SGihttp://multibriefs.com/briefs/SGI/SGI.xmlenIn high-resource settings, the practice of controlled cord traction for the management of placenta expulsion is not associated with a decreased incidence of postpartum hemorrhage, according to the results of a study conducted in France. Because most cases of postpartum hemorrhage result from uterine atony — the failure of the uterus to contract after delivery of the baby and the placenta — measures to prevent this complication have been recommended for all women who give birth. 14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=519238d7731251Balanced diet is the natural source of micronutrients, such as folate and vitamins, vital for proper functioning of the body. One-carbon metabolic pathway along with folate and other vitamins plays an important role in DNA synthesis and in the establishment of epigenetic modifications like DNA/histone methylation. Spermatogenesis involves distinct cellular, genetic, and chromatin changes during the course of production of male gamete sperm. 14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=519157a011fc62Urinary tract infections are common in women, and recurrence is a major clinical problem. Most UTIs are caused by uropathogenic Escherichia coli. UPEC are generally thought to migrate from the gut to the bladder to cause UTI. UPEC form specialized intracellular bacterial communities in the bladder urothelium as part of a pathogenic mechanism to establish a foothold during acute stages of infection. Evolutionarily, such a specific adaptation to the bladder environment would be predicted to result in decreased fitness in other habitats, such as the gut. To examine this prediction, we characterized 45 E. coli strains isolated from the feces and urine of four otherwise healthy women with recurrent UTI. 14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51915858b29a93Mutations in genes that occur spontaneously may contribute to congenital heart disease in children, according to a new study. These mutations — which arise after conception, rather than being inherited from a parent — may contribute to about 10 percent of cases of congenital heart disease in children, the study said.14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=519158cfab58a4Your 56-year-old, married, white patient has been on hormone therapy since age 52 for the treatment of vasomotor symptoms. She is taking a low-dose oral estrogen and micronized progesterone combination as she has an intact uterus. Her family history is positive for breast cancer, as her mother was diagnosed at age 68. Her most recent annual screening mammogram shows linear calcifications. Because fine, linear, branching or casting calcifications are worrisome for atypical ductal hyperplasia or ductal carcinoma in situ, a biopsy is recommended.14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51915978137705Patients with resected advanced ovarian cancer and low-volume residual disease fare better in the long term with intraperitoneal chemotherapy instead of intravenous chemotherapy. 14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51923b3f3cbce6The number of testicular cancer cases continues to climb slowly but steadily in the United States, according to new research.14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51923be3aff317Cancers were once named strictly for the tissue where they originated in the breast, prostate or other part of the body. Now, in the age of genetically informed medicine, cancers may also come with a more specific lexicon: the names of mutated genes deep within tumors that cause cells to become cancerous.14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51923c3ed2b588Maternal body mass index does not affect the efficacy of low-dose aspirin for preventing preeclampsia or preterm birth, according to a secondary analysis of data from the National Institute of Child Health and Human Development’s Maternal-Fetal Medicine Units Network trial. 14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51915ab0b525e9In a recent survey, researchers identified reasons for noncompliance regarding local estrogen therapy for vaginal atrophy by asking postmenopausal women why they switched to vaginal estradiol tablets from other formulations. According to data, 85 percent of the 79 women who completed the survey had used a vaginal cream, 9 percent had used the vaginal ring and 6 percent had used both cream and the ring before switching to the 10 mcg vaginal estradiol tablet (Vagifem, Novo Nordisk). 14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51915e0b0210c10Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread. The finding opens the door to drug treatments that prevent metastasis.14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51915a0fb464911Three in four pregnant women develop functional bowel disorders in their first trimester, with constipation and bloating most likely to negatively impact their everyday lives, researchers reported. "While overall quality-of-life measures are highly rated, constipation and bloating appear to negatively affect status, specifically body image," Scott C. Graziano, MD, of Loyola University Medical Center in Maywood, IL, and colleagues concluded in their poster presentation here at the annual clinical meeting of the American Congress of Obstetricians and Gynecologists. 14 May 2013 17:06:12 CDThttp://multibriefs.com/ViewLink.php?i=51915c2a3908312