Women's Cancer News
Mar. 25, 2015

Angelina Jolie Pitt: Diary of a Surgery
The New York Times
Angelina Jolie Pitt writes: Two years ago I wrote about my choice to have a preventive double mastectomy. A simple blood test had revealed that I carried a mutation in the BRCA1 gene. It gave me an estimated 87 percent risk of breast cancer and a 50 percent risk of ovarian cancer. I lost my mother, grandmother and aunt to cancer. I wanted other women at risk to know about the options. I promised to follow up with any information that could be useful, including about my next preventive surgery, the removal of my ovaries and fallopian tubes.More

Special Interest Session VIII: DoD Ovarian Academy Abstract Session

Find out about the latest science coming from the Department of Defense’s Ovarian Academy during Special Interest Session VIII: Department of Defense Ovarian Academy Abstract Session on Monday, March 30, from 4:00 p.m. – 5:15 p.m. at the Hilton Chicago during the SGO Annual Meeting.More

Endometrial Cancer ACOG SGO Practice Bulletin
ACOG and SGO
Endometrial carcinoma is the most commonly diagnosed gynecologic malignancy; almost every gynecologist will encounter it. A thorough understanding of the epidemiology, pathophysiology, and diagnostic and management strategies for this type of cancer allows the obstetrician–gynecologist to identify women at increased risk, contribute toward risk reduction, and facilitate early diagnosis. The purpose of this document is to review the current understanding of endometrial cancer and to provide guidelines for management that have been validated by appropriately conducted outcome-based research when available.More

Intraperitoneal chemotherapy improves 10-year ovarian cancer survival
Cancer Network
The use of intraperitoneal (IP) chemotherapy for the treatment of advanced ovarian cancer resulted in a survival benefit that extended beyond 10 years compared with intravenous chemotherapy, according to a pooled analysis of data from the Gynecologic Oncology Group (GOG) protocols 114 and 172. “The long-term survival benefits described in this report may encourage more clinicians to adopt IP chemotherapy in the community,” Devansu Tewari, MD and colleagues wrote in the Journal of Clinical Oncology.More

Early-onset alopecia may signal chemotherapy response for ovarian cancer
Cancer Network
Onset of alopecia, a common side effect of chemotherapy, within the first 3 cycles of platinum- and taxane-based chemotherapy was associated with improved overall survival (OS) among patients with epithelial ovarian cancer who completed 6 cycles of treatment. These results, published in the European Journal of Cancer, are taken from a meta-analysis of four prospective phase III trials that included 5,114 patients assigned platinum- and taxane-based chemotherapy for advanced epithelial ovarian cancer.More

Complementary therapies can boost survival in cancer patients
Medscape (Free login required)
A large percent of cancer patients use some form of complementary and alternative medicine (CAM), typically with the goal of relieving pain and controlling the adverse effects of disease or treatment. A new review of evidence drawn from experimental and epidemiologic studies, as well as a few clinical trials, demonstrates that several of the integrative approaches and lifestyle changes might also influence cancer survivorship. The review was published online in Current Oncology Reports.More

Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis
Oncogene
The cross-talk between ovarian cancer (OvCa) cells and the metastatic microenvironment is an essential determinant of successful colonization. MicroRNAs (miRNAs) have several critical roles during metastasis; however, the role of microenvironmental cues in the regulation of miRNAs in metastasizing cancer cells has not been studied.More

Pathologists interpreting breast biopsy highly accurate
Cancer Therapy Advisor
Individual pathologists' interpretations of a single breast biopsy slide generally concur with expert consensus-derived reference diagnoses, according to a study published in the Journal of the American Medical Association. Joann G. Elmore, MD, MPH, from the University of Washington in Seattle, and colleagues quantified the magnitude of diagnostic disagreement among pathologists compared with a consensus panel reference diagnosis in interpretation of breast biopsies.More

PBS to air in 'Cancer: The Emperor of all Maladies'
New York Daily News
If we can't always beat cancer, says Ken Burns, at least we need to strip away some of its psychological power. “No other disease has the same impact as cancer,” says Burns, executive producer of “Cancer: The Emperor of All Maladies,” a three-part PBS series that will air March 30-April 1. It's directed by Barak Goodman and based on a book by Dr. Siddhartha Mukherjee.More