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ASCO: Take family history in every new cancer patient
Medscape (Free login required)
Oncologists seeing a new patient with cancer should take a family history, specifically asking about cancer in first- and second-degree relatives, says the American Society of Clinical Oncology (ASCO) in a new expert statement. These are the first ever recommendations on taking a family history in cancer patients, ASCO noted, although the society has previously provided guidance on genetic testing and inherited cancer predispositions.
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GENETICS


Inherited gene mutations found in 20 percent of women with ovarian cancer
Medical News Today
Genetic studies of inherited predisposition to ovarian cancer have tended to focus on women with a known family history of the disease. Now, a new study of ovarian cancer patients with no known family history of the disease found one fifth of them had inherited alterations in genes known to be linked to ovarian and breast cancer.
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TGen study finds genetic origins of breast cancer that spreads to brain
Medical Xpress
The Translational Genomics Research Institute (TGen) has uncovered possible genetic origins of breast cancer that spreads to the brain, according to a first-of-its-kind study published in the scientific journal PLOS ONE. The compendium of genetic targets uncovered by TGen now can be used to identify potential new methods of diagnosis and new drug therapies for the estimated 45,000 patients in the U.S. each year whose cancer spreads from the breast to the brain.
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Rapid BRCA testing informs choice of mastectomy
Medscape (Free login required)
Italian researchers studied a rapid genetic counseling and testing intervention offered to women who had just been diagnosed with breast cancer and who were considered at risk of carrying BRCA1 or BRCA2 germline mutations. The investigators hypothesized that multidisciplinary approaches and rapid testing could influence the choice of primary surgery, and they explored the psychological repercussions of this approach.
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OVARIAN CANCER


An aspirin a day to reduce your ovarian cancer risk? Maybe, NCI study says, but more research needed
The Plain Dealer
Women who take aspirin daily may reduce their risk of ovarian cancer by 20 percent — or even more with the low-dose variety — according to a study led by scientists at the National Cancer Institute, published in the Journal of the National Cancer Institute. The researchers, however, are quick to say that physicians shouldn't start prescribing aspirin for that purpose until more studies are conducted.
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HPV


Report: Most US girls remain unvaccinated against HPV
Healio
The President’s Cancer Panel issued a call to increase the human papillomavirus (HPV) vaccination rate in the United States and worldwide by promoting awareness, acceptance and availability of the vaccine. The panel’s report included data from the CDC, which indicated only one-third of girls and less than 7 percent of boys in the United States aged 13 to 17 years had received the three recommended doses of the HPV vaccine in 2012.
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ASSAYS AND ARRAYS


Disagreement found between miRNA tools used to predict ovarian cancer survival
BioNewsTexas
Researchers led a study that used either Agilent microarrays or miRNA Next Generation Sequencing (miRNA-Seq) and data from the Cancer Genome Atlas (TCGA) on the same miRNA specimens from ovarian cancer patients and found two very different results. The microarrays identified 61 miRNAs associated with survival in 469 of the specimens, but miRNA-Seq found only 12. The overlap of the two methods was a single miRNA sequence associated with survival.
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Catching viruses associated with cervical cancer
Chemistry World
Researchers have developed a quick and efficient bioassay that uses surface-enhanced Raman scattering spectroscopy (SERS) to differentiate between different human papillomavirus (HPV) genotypes. SERS is a powerful and sensitive spectroscopic tool that is highly suited to the simultaneous detection of more than one target. By using specific probes and magnetic nanoparticles the team have demonstrated that their SERS assay is just as sensitive as standard tests with the added advantages of increased throughput, reduced turn-around times and the ability to detect multiple targets in an individual sample.
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MORCELLATION


Uterine surgical technique is linked to abnormal growths and cancer spread
The New York Times
Concerns are increasing among doctors about the safety of a procedure performed on tens of thousands of women a year in the United States who undergo surgery to remove fibroid tumors from the uterus, or to remove the entire uterus. The procedure, morcellation, cuts tissue into pieces that can be pulled out through tiny incisions. The technique is part of minimally invasive surgery, which avoids big incisions, shortens recovery time and reduces the risks of blood loss, infection and other complications.
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Women's Cancer News
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