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Bevacizumab promising in locally advanced cervical cancer
Oncology Nurse Advisor
A phase 2 trial of bevacizumab (Avastin) in addition to cisplatin and pelvic radiation for locally advanced cervical cancer found that adding bevacizumab to the existing standard of care was safe and showed promising overall results. The 2- and 3-year overall survival rates were 89.8 percent and 80.2 percent, respectively.
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OVARIAN CANCER


Removing ovaries puts bones and carotids at risk
MedPage Today
Oophorectomy prior to menopause was associated with a greater risk for carotid artery thickening and bone loss more than a decade post menopause, researchers found. After excluding women who used estrogen or bisphosphonates, women without their ovaries showed a larger rate of bone mineral density decline in the lumbar spine compared with women with intact ovaries, both 5 to 10 years after menopause and more than 10 years after menopause, Sara J. Mucowski, M.D., of the University of Southern California Keck Medical Center in Los Angeles, and colleagues wrote online Feb. 14 in Fertility and Sterility.
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GENETICS


Double mastectomy and inherited breast cancer
HealthDay News via U.S. News & World Report
Women diagnosed with an inherited form of breast cancer might halve their risk of dying of the disease if they remove both breasts, a new study suggests. "I think we've shown pretty clearly that if you have breast cancer and the BRCA mutation, your best option is to get both breasts removed at the outset," said study author Dr. Steven Narod, a senior scientist with the University of Toronto's Women's College Research Institute, in Canada. The research, published in the Feb. 11 issue of the journal BMJ, is the first evidence that shows having a so-called bilateral mastectomy actually saves the lives of women with early stage breast cancer and mutations in their BRCA genes, the study authors said.
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RESEARCH


Small molecules stop cervical cancer virus assembling
Chemistry World
Researchers in China have disrupted the life cycle of the leading cause of cervical cancer – the human papillomavirus – using a macrocyclic molecule called a pillarene. The team hope their findings will offer new prophylactic avenues against the virus. The pillarene derivative, CP5A, was tested as it is known to have high water solubility and show selective binding towards basic amino acids, like l-Lysine, l-arginine and l-histidine. Because of these properties, CP5A binds to the exposed basic amino acids in protein L1, preventing pentamer formation, and therefore stopping the creation of viral particles.
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HPV


Popular disinfectants do not kill HPV
Science Daily
Commonly used disinfectants do not kill human papillomavirus (HPV) that makes possible non-sexual transmission of the virus, thus creating a need for hospital policy changes, according to a study. "Because it is difficult to produce infectious HPV particles for research, little has been known about HPV susceptibility to disinfection," said Craig Meyers, Distinguished Professor of Microbiology and Immunology, Penn State College of Medicine.
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OBESITY


GOED on new cancer study: 'Results do not support a change in omega-3 intake'
NutraIngredients-USA
Epidemiological data published in the American Journal of Clinical Nutrition suggested that there was an association between high omega-3 intakes and an increased risk of endometrial cancer in overweight and obese women. On the other hand, increased intakes of omega-3s for normal-weight women were associated with statistically significant reductions in cancer risk, said researchers.
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BREAST CANCER


Potential options for attacking stem cells in triple-negative breast cancer
ScienceDaily
New research from the University of Michigan Comprehensive Cancer Center and Georgia Regents University finds that a protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells. This provides a potential target for treating triple negative breast cancer, the most aggressive form of the disease. The researchers identified a protein, SOCS3, that is highly expressed in normal cells but undetectable in triple-negative breast cancer.
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Women's Cancer News
Colby Horton, Vice President of Publishing, 469.420.2601
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Jessica Taylor, Senior Medical Editor, 202-684-7169  
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