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Bevacizumab approved in England for advanced cervical cancer
The Guardian
Women in England who are dying of cervical cancer are to receive a drug that could extend their lives by as much as four months. Women with advanced cervical cancer will be able to get Avastin, which is also known as bevacizumab, after NHS England decided to fund courses of treatment with it for such patients. Avastin is already used to treat advanced forms of breast, lung, bowel, ovarian and kidney cancer. NHS England has now included it on the Cancer Drugs Fund's list of approved medications for use by cervical cancer sufferers who are near the end of their lives.
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CERVICAL CANCER


Targeted drug shows promise in cervical cancer
Science Codex
The epidermal growth factor receptor inhibitor erlotinib appears to be effective in locally advanced cervical cancer, Brazilian researchers have found in a breakthrough study. Published online in Cancer, the study involved 36 women with stage IIB to IIIB epidermoid cervical cancer who were given erlotinib at a dose of 150mg/day one week before and in combination with cisplatin-based chemoradiation.
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PREVENTION


ASCO Report: Cancer will be No. 1 killer in US
CNN
In 16 years, cancer will become the leading cause of death in the United States, surpassing heart disease, according to a new report from the American Society of Clinical Oncology (ASCO). The number of new cancer cases is expected to increase nearly 45 percent by 2030, from 1.6 million cases to 2.3 million cases annually. This influx of new patients will place a bigger burden on a field of medicine already stretched by physician shortages and financial difficulties, says the report, which highlights growing problems for cancer care in the United States.
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Report: Excess weight a risk factor for ovarian cancer
HealthDay News
A new report reveals that excess weight raises the risk of yet another kind of cancer, with the latest results linking levels of body fat to ovarian tumors. The chances for developing many cancers — such as postmenopausal breast, colorectal, endometrial, esophageal, kidney, gallbladder and pancreatic cancers — are known to increase with a person's weight, but the evidence for any such link to ovarian cancer has been inconclusive until now, the report authors said.
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Cancer screening rates fall below CDC target goals
Medscape (Free login required)
When it comes to cancer screening, the Healthy People initiative is short of meeting its targets, particularly for certain population subgroups. From 2008 to 2010, overall rates of breast and cervical cancer screening slightly decreased, but screening rates for colorectal cancer rose by 7 percentage points. The rates of cancer screening and counseling by healthcare providers were also below designated targets. "Our report tracks established Healthy People objectives," said report author Carrie N. Klabunde, Ph.D., an epidemiologist in the Health Services and Economics of the National Cancer Institute. "There are Healthy People objectives and target screening rates for breast, cervical, and colorectal cancer screening, all of which are recommended by the US Preventive Services Task Force."
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GENETICS


Patentholder on breast cancer tests denied injunction in lawsuit
The New York Times
Myriad Genetics, which lost a closely watched Supreme Court case last year involving the patenting of genes, has suffered another setback in its efforts to protect its main genetic test from competition. A federal judge denied Myriad’s request for a preliminary injunction that would have immediately stopped a rival company, Ambry Genetics, from offering a similar test. Myriad’s lucrative monopoly on testing for mutations in two genes linked to breast cancer risk was shattered last June by the Supreme Court’s ruling that genes were not eligible for patents because they were products of nature.
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BREAST CANCER


Yoga may help breast cancer patients
HealthDay News via WebMD
Women with breast cancer who practiced yoga had lower levels of stress hormones and new research shows less fatigue and better quality of life, new research shows. "Yoga is having an impact on subjective well-being, as well as better regulation of cortisol, a stress hormone," said study co-author Lorenzo Cohen, director of the integrative medicine program at M.D. Anderson Cancer Center, in Houston. "Better regulation of stress hormones has been linked with better survival and longer survival."
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Trastuzumab/Eribulin combo safe and effective in HER2-positive breast cancer
OncLive
The first-line combination of trastuzumab and eribulin mesylate demonstrated an objective response rate (ORR) of 71.2 percent with a median progression-free survival (PFS) of 11.6 months in patients with HER2-positive advanced breast cancer, according to final results from a phase II study presented in a poster session at MBCC. “Patients that have HER2-positive disease are now being treated with pertuzumab and trastuzumab in the first-line, T-DM1 in the second-line, at some point maybe lapatinib, or maybe capecitabine plus lapatinib,” said Debu Tripathy, M.D., said.
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