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Lgr5 biomarker may help detect ovarian cancer earlier, aid in personalized treatment
Medical Daily
Scientists publishing July 6 in Nature Cell Biology have identified a biomarker, a molecule known as Lgr5, in the ovarian stem cells. With this biomarker they are optimistic that ovarian cancers can be detected early. The molecule Lgr5 is present in the ovarian surface epithelium. While it has been found to be present in the stem cells of other tissues such as intestine and stomach, this is the first time that scientists have located it in the ovary.
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MORCELLATION


Morcellation isolation bag deemed feasible
Medscape (Free login required)
Using an isolation bag during morcellation is feasible and could potentially improve the safety of minimally invasive gynecologic surgery, according to a cohort study published Aug. 5 in Obstetrics & Gynecology. "Morcellation within an insufflated isolation bag is a feasible technique," write Sarah L. Cohen, M.D., MPH, from the Division of Minimally Invasive Gynecologic Surgery, Brigham and Women’s Hospital, and the Center for Minimally Invasive Gynecologic Surgery, Massachusetts General Hospital, Boston, Massachusetts, and colleagues.
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RESEARCH


Cancer should be classified by genetic and molecular type, say scientists
Medical News Today
Researchers from The Cancer Genome Atlas (TCGA) propose that cancer should be classified according to genetic and molecular features rather than by the type of tissue in which the tumor arises. While more work is needed to confirm and build on findings that look set to rewrite oncology textbooks, the scientists write in the Aug. 7 online issue of Cell that such a system would be better for patients because it would help tailor treatment to their individual needs.
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Editing HPV's genes to kill cervical cancer cells
Bioscience Technology
Researchers have hijacked a defense system normally used by bacteria to fend off viral infections and redirected it against the human papillomavirus (HPV). Using the genome editing tool known as CRISPR, researchers publishing Aug. 7 in the Journal of Virology were able to selectively destroy two viral genes responsible for the growth and survival of cervical carcinoma cells, causing the cancer cells to self-destruct.
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PREVENTION


Salpingectomy as a primary sterilization procedure?
Medscape (Free login required)
Salpingectomy should be the primary female sterilization procedure because it is permanent and may prevent some types of ovarian cancer that actually begin in the fallopian tube, according to a commentary published online Aug. 5 in Obstetrics & Gynecology. Recent research findings that ovarian cancer may frequently originate in the fallopian tube, along with advances in technology making salpingectomy no greater risk than tubal occlusion, warrant consideration of this practice-changing move.
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PALLIATIVE CARE


Rehabilitation benefits advanced cancer patients
Oncology Nurse Advisor (Free login required)
Patients with advanced cancer can benefit from a rehabilitation program combining exercise, nutritional counseling, and symptom control, according to an evidence review in the Canadian Medical Association Journal. Palliative care programs should be expanded to include these elements and should be available to patients from diagnosis. Programs for people with earlier stage cancer combine diet and exercise, but few programs include patients with advanced cancer.
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BREAST CANCER


PALB2, BRCA2 gene mutations confer similar breast cancer risk
OncLive
Women harboring a loss-of-function mutation in the PALB2 gene demonstrated an increased risk of developing breast cancer that was similar to the predisposition seen with mutations in the infamous BRCA gene, according to a study published in The New England Journal of Medicine. The estimated cumulative risk of breast cancer for female PALB2 mutation carriers was 14 percent by age 50 and 35 percent by 70, representing a significant increase over the general population.
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Women's Cancer News
Colby Horton, Vice President of Publishing, 469.420.2601
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Jessica Taylor, Senior Medical Editor, 202-684-7169  
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