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Pemetrexed plus cisplatin active in advanced, recurrent cervical carcinoma
HemOncToday
The combination of pemetrexed and cisplatin appeared safe and effective in women with advanced, persistent or recurrent carcinoma of the cervix, according to results of a phase 2 trial published in the Journal of Clinical Oncology. “This combination should be further developed in the treatment of cervical cancer,” David Scott Miller, MD, professor of obstetrics and gynecology at UT Southwestern Medical Center, and colleagues wrote. “Given that it may be less toxic than and as active as cisplatin plus paclitaxel, and that it can be combined with bevacizumab (Avastin, Genentech), comparison of cisplatin–pemetrexed plus bevacizumab with cisplatin–paclitaxel plus bevacizumab would be appropriate.”
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CERVICAL CANCER


Report shows HPV vaccine trials can be shortened significantly
Infection Control Today
A new report, Primary End-points for Prophylactic HPV Vaccine Trials, from a working group convened by the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization, and the United States National Cancer Institute (NCI) shows how the evaluation and licensing of prophylactic human papillomavirus (HPV) vaccines could be significantly accelerated. Experts with wide-ranging expertise in HPV vaccines reviewed the scientific evidence to determine under what circumstances vaccine efficacy can be established at an earlier stage of the infection, rather than the clinical onset of disease in the cervix.
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HTI-1968 shuts down HPV that causes most cervical cancer
The Pharma Letter (Subscription required)
Research presented at the 29th Annual International Papillomavirus Conference shows that a therapy being developed by privately-held US firm Hera Therapeutics combats three types of human papillomavirus, including the two that cause 70 percent of all cervical cancer. When tested in several cultured human cell models, HTI-1968 blocked the replication of HPV-16, HPV-18 and HPV-11 cells, according to Louise Chow and Thomas Broker, who presented the findings at the Seattle conference.
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SURVIVORSHIP


DHEA therapy offers relief from vaginal symptoms in cancer survivors
OncLive
A randomized multicenter trial examining the efficacy of adding dehydroepiandosterone (DHEA) to a vaginal bioadhesive moisturizer in postmenopausal survivors of breast or gynecologic cancer has found that daily rather than as-needed use of such a moisturizer significantly relieves symptoms of vaginal atrophy in these women, and that when DHEA is added, survivors report significant improvements in sexual desire, arousal, pain, and overall sexual function.
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HEALTH POLICY


Medicaid: Do differing state reimbursement policies affect cancer screening?
Medical News Today
Although Medicaid programs across the U.S. provide access to breast, cervical and colorectal cancer screening, there is no guarantee that these services will be fully utilized. Evidence published in Cancer suggests that Medicaid users were less likely to receive cancer screening than individuals with private health insurance, and they were more likely to present themselves with advanced stages of cancer than individuals with private health insurance or Medicare provision.
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BREAST CANCER


Bisphosphonate treatment did not reduce risk for postmenopausal breast cancer
HemOnc Today
Treatment with bisphosphonates for osteoporosis provided no protective effect against the risk for invasive postmenopausal breast cancer, according to an analysis of results from two randomized, double blind, placebo-controlled trials published in JAMA. These results contradict findings from observational studies that suggest bisphosphonates may suppress the proliferation of estrogen-sensitive breast cancer cells.
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Women's Cancer News
Colby Horton, Vice President of Publishing, 469.420.2601
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Jessica Taylor, Senior Medical Editor, 202-684-7169  
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