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Etirinotecan pegol active in platinum-resistant ovarian cancer
Journal of Clinical Oncology via Healio
Two different dosing regimens of single-agent etirinotecan pegol were associated with encouraging response rates, OS and PFS in patients with platinum-resistant ovarian cancer, according to results of a randomized phase 2 study. Etirinotecan pegol is a long-acting topoisomerase-I inhibitor with prolonged systemic exposure to 7-ethyl-10-hydroxycamptothecin, the active metabolite of irinotecan, according to background information in the study.
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GENETICS


Researchers spar over tests for breast cancer risks
Science
A heated discussion broke out here today at the annual meeting of the American Society of Human Genetics over a hot-button topic: When will we know enough about rare cancer risk genes to begin routinely testing for them in patients with a family history of cancer? On one side of the debate was a team led by breast cancer geneticist Mary-Claire King, who discovered the first inherited breast cancer risk gene, BRCA1. King's group now wants to routinely test certain women for other cancer-linked genes. Other researchers, however, argued that it is premature to test for these other genes, which are less well understood.
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HPV VACCINE


New HPV vaccine promises to prevent 85 percent of invasive cervical cancer
Ob.Gyn.News
An investigational 9-valent human papillomavirus vaccine could prevent up to 85 percent of invasive cervical cancer, according to a spokesman for Merck, the company developing the product. The vaccine adds five new HPV strains to the four already included in the current quadrivalent vaccine. The addition of HPV strains 31/33/45/52/58 should protect against the 30% of cervical cancers that are not caused by HPV 16 and 18, Dr Alain Luxembourg said at a meeting of the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices in Atlanta.
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Scandinavia study finds HPV vaccine safe
Reuters
In a large study of nearly a million girls in Denmark and Sweden, the human papillomavirus vaccine was not linked to short- or long-term health problems. The HPV vaccine, given in three doses over a period of six months to boys and girls around age 12, protects against infection by a virus that can cause cervical cancer. "There were not really any concerns before our study and no new ones after," Lisen Arnheim-Dahlström said. She led the study at the Karolinska Institutet in Stockholm.
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HPV strains affecting African-American women differ from vaccines
NBCNEWS.com
Two cervical cancer vaccines that are recommended for all pre-teen and early teen boys and girls miss the strains most likely to infect black women, researchers reported Monday. But a new vaccine in advanced development may protect against many more of the strains, and in the meantime researchers say parents should definitely keep vaccinating their kids.
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TREATMENT


Living with cancer: Brains on chemo
The New York Times
Chemo brain is a phenomenon that patients have described for quite some time as a thick mental fog resulting from chemotherapy. For quite some time, too, physicians discounted chemo brain as a figment of patients' imaginations. Now, however, the American Cancer Society terms it "a mild cognitive impairment" that for most people only lasts a short time. Doctors were skeptical about chemo brain because many factors can induce mental glitches. Forgetfulness, trouble concentrating, memory blanks, inattention, word loss, retention problems and disorganization can result from aging, sleeplessness, depression, fatigue, anxiety, low blood counts, the onset of menopause and other medications.
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Social service barriers delay care among women with abnormal cancer screening
Journal of General Internal Medicine via ScienceDaily
A recent study performed by researchers at Boston Medical Center, Boston University School of Medicine, Boston University School of Public Health, and Tufts Medical Center found that women with multiple barriers to healthcare, especially those with social barriers such as problems with housing and income, experienced delays in cancer screening follow up compared to those with fewer barriers or no social barriers. The study, which appears online in the Journal of General Internal Medicine, was led by Sarah Primeau, MSW, research assistant in the department of general internal medicine at BUSM.
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RESEARCH


HIV drugs may get new role in fighting cancer
Reuters
A type of HIV medicine that stops the AIDS virus from entering immune system cells could in future be put to work against cancer in new combination therapies being developed by drug companies. Interest in using so-called CCR5 inhibitors to fight tumors was fuelled last year when U.S. researchers, testing the drugs on mice, reported a marked reduction in aggressive breast cancer cells spreading to the animals' lungs.
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Women's Cancer News
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